A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus [PDF]
Cell Reports, 2018 Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution.
Shiwei Chen +7 more
doaj +8 more sources
Restructuring of Lamina-Associated Domains in Senescence and Cancer
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
doaj +7 more sources
Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging [PDF]
Nature CommunicationsChromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression.
Monika Dhankhar +9 more
doaj +7 more sources
Lamina Associated Domains and Gene Regulation in Development and Cancer [PDF]
Cells, 2019 The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization.
Silke J. A. Lochs +2 more
doaj +6 more sources
A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling [PDF]
ResearchSUN1/2, core components of the linker of nucleoskeleton and cytoskeleton complex, transmit extracellular mechanical forces to nuclear lamina and chromatin.
Yafan Xie +11 more
doaj +3 more sources
Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells [PDF]
EMBO Reports, 2015 In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state. Lamins form the major structural component of the lamina and have been reported to bind DNA and chromatin.
Bas van Steensel, Mario Amendola
exaly +6 more sources
The assessment of posterior ocular structures in Turkish children with anisometropic amblyopia [PDF]
BMC OphthalmologyBackgrounds To investigate whether unilateral amblyopia in childhood is associated with structural alterations in the retina, optic nerve head, and lamina cribrosa by means of optical coherence tomography (OCT).
Elvin Halili Çelenk, Banu Torun Acar
doaj +2 more sources
Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]
, 2001 Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF +8 more
core +6 more sources
Single Cell Mechanics in Disease Progression [PDF]
Small ScienceMechanical force transmission is essential for maintaining cellular structure and function. Forces generated by the extracellular matrix (ECM) and neighboring cells are transmitted via adhesion and junctional complexes to the cytoskeleton and nucleus ...
Sabin Kim +3 more
doaj +2 more sources
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome [PDF]
Genome Medicine, 2020 Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope
Florian Köhler +9 more
openaire +4 more sources