Results 11 to 20 of about 53,308 (249)
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome [PDF]
Genome Medicine, 2020 Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope
Florian Köhler +9 more
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Lamina-associated domains: Tethers and looseners
Current Opinion in Cell Biology, 2022 Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation ...
Manzo, Stefano Giustino +2 more
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Lamina-associated domains: peripheral matters and internal affairs [PDF]
Genome Biology, 2020 AbstractAt the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data.
Briand, Nolwenn, Collas, Philippe
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Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. [PDF]
PLoS ONE, 2009 Nuclear lamin filaments and associated proteins form a nucleoskeletal ("lamina") network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans.
Rocío Montes de Oca +4 more
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Optic nerve cavitations in glaucoma suspect and glaucoma patients
American Journal of Ophthalmology Case Reports, 2022 Purpose: Glaucoma is associated with structural changes of the optic nerve head such as deformation, lamina cribosa defects, prelaminar schisis, and peripapillary retinal schisis. We describe optic nerve cavitations that were detected by routine spectral
Bennett Y. Hong +5 more
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Role of histone deacetylases in gene regulation at nuclear lamina.
PLoS ONE, 2012 Theoretical models suggest that gene silencing at the nuclear periphery may involve "closing" of chromatin by transcriptional repressors, such as histone deacetylases (HDACs). Here we provide experimental evidence confirming these predictions.
Beatrice C Milon +7 more
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Mapping the micro-proteome of the nuclear lamina and lamin associated domains [PDF]
Life Science Alliance, 2019 Abstract The nuclear lamina is a proteinaceous network of filaments that provide both structural and gene regulatory functions by tethering proteins and large domains of DNA, so-called lamin associated domains (LADs), to the periphery of the nucleus. LADs are a large fraction of the mammalian genome that are repressed, in part, by their
Xianrong Wong +6 more
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The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
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Frontiers in Genetics, 2019 Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate whether chromatin periodically associates with nuclear lamins.
Annaël Brunet +5 more
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Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography. [PDF]
PLoS ONE, 2018 PURPOSE:To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes.
Tadamichi Akagi +8 more
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