Agrin binds to the nerve-muscle basal lamina via laminin. [PDF]
, 1997 Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Brandenberger, R +14 more
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The role of lamin A and emerin in mediating genome organisation [PDF]
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The nuclear matrix (NM) is proposed to be a permanent network of core filaments underlying thicker fibres, present regardless of transcriptional activity ...
Godwin, Lauren Sarah
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Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography. [PDF]
PLoS ONE, 2018 PURPOSE:To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes.
Tadamichi Akagi +8 more
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Frontiers in Genetics, 2019 Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate whether chromatin periodically associates with nuclear lamins.
Annaël Brunet +5 more
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The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
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Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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Structural studies on protein scaffolds related to muscle physiology and disease : the titin filament, its associated component MuRF-1 and nuclear LAP2[alpha] [PDF]
, 2006 The titin molecule has a length of overµm and functions as a colossal protein scaffold in the muscle sarcomere. Up to 90% of its total mass is composed of repetitive immunoglobulin (Ig) and fibronectin (FnIII) domains that form linear tandems ...
Mrosek, Michael Christian
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3D chromatin architecture and transcription regulation in cancer
Journal of Hematology & Oncology, 2022 Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation.
Siwei Deng, Yuliang Feng, Siim Pauklin
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Lamina-associated polypeptide 2 (LAP2) expression patterns in transformed and cancer cells [PDF]
, 2009 The Lamina-associated polypeptide two (LAP2) proteins comprising three human isoforms, LAP2 +- LAP2β and LAP2 have been shown to provide a structural framework in the nucleus and to facilitate nuclear assembly and disassembly during the cell ...
Ward, Michelle Claire
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