Genes & Development, 2023 Fertilization in mammals is accompanied by an intense period of chromatin remodeling and major changes in nuclear organization. How the earliest events in embryogenesis, including zygotic genome activation (ZGA) during maternal-to-zygotic transition, influence such remodeling remains unknown.
Mrinmoy Pal +3 more
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Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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3D chromatin architecture and transcription regulation in cancer
Journal of Hematology & Oncology, 2022 Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation.
Siwei Deng, Yuliang Feng, Siim Pauklin
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Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation [PDF]
Nucleus, 2018 The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. Mutations in A-type nuclear lamins cause laminopathies, some of which are associated with a loss of heterochromatin at the nuclear periphery. Until recently however, little if any information has been provided on where and how lamin A interacts with the ...
Briand, Nolwenn, Collas, Philippe
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Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery. [PDF]
PLoS ONE, 2018 PURPOSE:To assess whether lamina cribrosa depth (LCD) reduction and the rate of change in LCD over time (ΔLCD/Δt) is associated with retinal nerve fiber layer (RNFL) thickness and the rate of RNFL thinning over time (ΔRNFL/Δt) to test the hypothesis that,
Patrycja Krzyżanowska-Berkowska +3 more
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Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin [PDF]
Epigenetics & Chromatin, 2022 Abstract Background Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of 3D chromatin structure and dynamics; however, relevant genome-wide experiments that may provide ...
Igor S Tolokh +3 more
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Cell Cycle Dynamics of the Nuclear Envelope
The Scientific World Journal, 2003 The nuclear envelope (NE) consists of an inner and an outer membrane, nuclear pore complexes, and the underlying nuclear lamina, a filamentous scaffold structure formed by lamins.
Roland Foisner
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TAD cliques predict key features of chromatin organization
BMC Genomics, 2021 Background Mechanisms underlying genome 3D organization and domain formation in the mammalian nucleus are not completely understood. Multiple processes such as transcriptional compartmentalization, DNA loop extrusion and interactions with the nuclear ...
Tharvesh M. Liyakat Ali +3 more
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Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains [PDF]
, 2018 Abstract It is largely unclear whether genes that are naturally embedded in lamina associated domains (LADs) are inactive due to their chromatin environment, or whether LADs are merely secondary to the lack of transcription. We show that hundreds of human promoters become active when moved from their native LAD position to a neutral ...
Leemans, Christ +7 more
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