Results 21 to 30 of about 10,232,392 (268)

Lamina-associated domains: peripheral matters and internal affairs [PDF]

Genome Biology, 2020
AbstractAt the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data.
Briand, Nolwenn, Collas, Philippe
openaire   +4 more sources

Cellular and Genomic Features of Muscle Differentiation from Isogenic Fibroblasts and Myoblasts

Cells, 2023
The ability to recapitulate muscle differentiation in vitro enables the exploration of mechanisms underlying myogenesis and muscle diseases. However, obtaining myoblasts from patients with neuromuscular diseases or from healthy subjects poses ethical and
Louise Benarroch, Julia Madsen-Østerbye, Mohamed Abdelhalim, Kamel Mamchaoui, Jessica Ohana, Anne Bigot, Vincent Mouly, Gisèle Bonne, Anne T. Bertrand, Philippe Collas   +9 more
doaj   +1 more source

Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions

Frontiers in Cell and Developmental Biology, 2022
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye, Aurélie Bellanger, Natalia M. Galigniana, Natalia M. Galigniana, Philippe Collas, Philippe Collas   +5 more
doaj   +1 more source

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

Agrin binds to the nerve-muscle basal lamina via laminin. [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Brandenberger, R, Ralph Brandenberger, Matthias Gesemann, Gesemann, M., Denzer, A. J., Chiquet, M, Ruegg, M. A., Denzer, A J, Brandenberger, R., Markus A. Ruegg, Matthias Chiquet, Gesemann, M, Ruegg, M A, Chiquet, M., Alain J. Denzer, Chiquet M, Denzer AJ, Gesemann M, Brandenberger R, Ruegg MA   +19 more
core   +1 more source

Mapping the micro-proteome of the nuclear lamina and lamin associated domains [PDF]

Life Science Alliance, 2019
Abstract The nuclear lamina is a proteinaceous network of filaments that provide both structural and gene regulatory functions by tethering proteins and large domains of DNA, so-called lamin associated domains (LADs), to the periphery of the nucleus. LADs are a large fraction of the mammalian genome that are repressed, in part, by their
Xianrong Wong, Jevon A Cutler, Victoria E Hoskins, Molly Gordon, Anil K Madugundu, Akhilesh Pandey, Karen L Reddy   +6 more
openaire   +3 more sources

Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity

Genes & Development, 2023
Fertilization in mammals is accompanied by an intense period of chromatin remodeling and major changes in nuclear organization. How the earliest events in embryogenesis, including zygotic genome activation (ZGA) during maternal-to-zygotic transition, influence such remodeling remains unknown.
Mrinmoy Pal, Luis Altamirano-Pacheco, Tamas Schauer, Maria-Elena Torres-Padilla   +3 more
openaire   +3 more sources

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]

, 1994
The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ, Kill, IR, Bridger, JM, Cox, LS   +3 more
core   +4 more sources

3D chromatin architecture and transcription regulation in cancer

Journal of Hematology & Oncology, 2022
Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation.
Siwei Deng, Yuliang Feng, Siim Pauklin
doaj   +1 more source

Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct populations of retained introns

, 2022
Raw files for microscopy and western blot data presented in this study.SUMMARYThe nucleus is highly compartmentalized through the formation of distinct classes of non-membranous domains, yet the composition and function of many of these structures is not
Barutcu, R (via Mendeley Data)
core   +1 more source