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Heterochromatin: Guardian of the Genome [PDF]
Annual Review of Cell and Developmental Biology, 2018 Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and ...
Aniek Janssen +2 more
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Nature Communications, 2021 The heterochromatin compartment is key for genome stability and cell fate transitions. Here, by tracking the heterochromatin response to UV damage in real time, the authors reveal how heterochromatin features are preserved following a genotoxic stress ...
Anna Fortuny +6 more
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The molecular basis of heterochromatin assembly and epigenetic inheritance
Molecular Cell, 2023 Summary Heterochromatin plays a fundamental role in gene regulation, genome integrity, and silencing of repetitive DNA elements. Histone modifications are essential for the establishment of heterochromatin domains, which is initiated by the recruitment ...
Shiv Grewal
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Diverse heterochromatin states restricting cell identity and reprogramming
Trends in Biochemical Sciences, 2023 Heterochromatin is defined as chromosomal domains harboring repressive H3K9me2/3 or H3K27me3 histone modifications and relevant factors that physically compact the chromatin.
Kenneth Zaret, Ryan L McCarthy
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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
Cell, 2017 In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression ...
Bas van Steensel, Andrew Belmont
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Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis [PDF]
Nature CommunicationsHeterochromatin formation is pivotal in many eukaryotes with repetitive sequences, such as transposable elements (TEs). However, in plants, where the known de novo DNA methylation mechanism (RdDM) targets euchromatin, how heterochromatin is formed in a ...
Shoko Oda +7 more
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Ten principles of heterochromatin formation and function
Nature Reviews Molecular Cell Biology, 2017 Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows particular genomic domains with specific functional properties.
Hiten Madhani, Robin Allshire
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Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis [PDF]
PLoS Genetics, 2012 Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial.
Amy Tsurumi +2 more
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Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus. [PDF]
PLoS ONECohesin mediates central features of chromosome architecture. The protein complex governs sister chromatid cohesion and organizes genomes into loops and domains.
Paul M Kraycer, Marc R Gartenberg
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Nature reviews. Molecular cell biology, 2022 Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing.
Jan Padeken +2 more
semanticscholar +1 more source