Results 11 to 20 of about 75,723 (273)
Heterochromatin Dynamics [PDF]
PLoS Biology, 2003 Heterochromatin is usually thought of as a stable and inactive region of the genome.
Tobias Straub +2 more
openaire +6 more sources
Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus. [PDF]
PLoS ONECohesin mediates central features of chromosome architecture. The protein complex governs sister chromatid cohesion and organizes genomes into loops and domains.
Paul M Kraycer, Marc R Gartenberg
doaj +2 more sources
Position effect variegation (PEV) as an aging clock: visualization of age-dependent loss of heterochromatin and longevity associated with enhanced heterochromatin [PDF]
Scientific ReportsThe heterochromatin loss model of aging suggests there is an age-dependent reduction in epigenetic factors that form and maintain the heterochromatin state of chromosomes.
Sesley Tedeschi +7 more
doaj +2 more sources
The Cell Biology of Heterochromatin
Cells, 2022 A conserved feature of virtually all higher eukaryotes is that the centromeres are embedded in heterochromatin. Here we provide evidence that this tight association between pericentric heterochromatin and the centromere is essential for proper metaphase ...
Brandt Warecki, William Sullivan
doaj +2 more sources
RNAi and Heterochromatin Assembly [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The involvement of RNA interference (RNAi) in heterochromatin formation has become clear largely through studies in the fission yeast Schizosaccharomyces pombe and plants like Arabidopsis thaliana. This article discusses how heterochromatic small interfering RNAs are produced and how the RNAi machinery participates in the formation and function of ...
Robert, Martienssen, Danesh, Moazed
openaire +3 more sources
Loss of SMARCAD1 Mitigates Tauopathy. [PDF]
Aging CellUsing genetics approaches in a C. elegans transgenic model of tauopathy, we uncover a role for the homolog of human SMARCAD1, a regulator of chromatin dynamics. ABSTRACT Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders.
Jadhav VS +7 more
europepmc +2 more sources
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
doaj +1 more source
Rapid epigenetic adaptation to uncontrolled heterochromatin spreading
eLife, 2015 Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.
Jiyong Wang, Bharat D Reddy, Songtao Jia
doaj +1 more source
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Epigenetics & Chromatin, 2021 Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood.
Martina Weigt +7 more
doaj +1 more source
DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
doaj +1 more source