Results 31 to 40 of about 102,384 (311)

Heterochromatin is a quantitative trait associated with spontaneous epiallele formation

, 2021
first release of analysis code for the paper "Heterochromatin is a quantitative trait associated with spontaneous epiallele ...
Frank Johannes, Hosung Jang, Robert S. Piecyk, Rui Xiao, Yinwen Zhang, Ioanna Kakoulidou, Robert J. Schmitz   +6 more
core   +1 more source

Structural Basis of Heterochromatin Formation by Human HP1

Molecular Cell, 2018
Yukihiko Sugita, Hitoshi Kurumizaka, Matthias Wolf   +2 more
exaly   +2 more sources

Genome mapping and characterization of the Anopheles gambiae heterochromatin

BMC Genomics, 2010
Background Heterochromatin plays an important role in chromosome function and gene regulation. Despite the availability of polytene chromosomes and genome sequence, the heterochromatin of the major malaria vector Anopheles gambiae has not been mapped and
Sharakhova Maria V, George Phillip, Brusentsova Irina V, Leman Scotland C, Bailey Jeffrey A, Smith Christopher D, Sharakhov Igor V   +6 more
doaj   +1 more source

Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain

Cell Research, 2022
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epigenetic change have remained unclear.
Yanxiao Zhang, Maria Luisa Amaral, Chenxu Zhu, S. Grieco, Xiaomeng Hou, Lin Lin, J. Buchanan, L. Tong, Sebastian Preissl, Xiangmin Xu, B. Ren   +10 more
semanticscholar   +1 more source

Regulation of heterochromatic RNA decay via heterochromatin protein 1 (HP1) [PDF]

, 2012
The central dogma of molecular biology describes the directional flow of biological information from DNA via RNA to protein. Information stored in DNA is copied to an mRNA molecule during the process of transcription.
Keller, Claudia Isabelle
core   +1 more source

Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs

Stem Cell Research & Therapy, 2020
Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics
Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li, Xiaohua Jiang   +7 more
doaj   +1 more source

PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina

Nucleus, 2023
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva, Yu-Chia Cheng, Cheryl L. Smith, Richard A. Katz, Andrey Poleshko   +4 more
doaj   +1 more source

Phase separation drives heterochromatin domain formation

Nature, 2017
Constitutive heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear architecture, DNA repair and genome stability, and silencing of transposon and gene expression.
Amy R. Strom, A. Emelyanov, Mustafa Mir, D. Fyodorov, X. Darzacq, G. Karpen   +5 more
semanticscholar   +1 more source

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

Molecules and Cells, 2022
Summary Gene silencing by heterochromatin plays a crucial role in cell identity. Here, we characterize the localization, the biogenesis, and the function of an atypical heterochromatin, which is simultaneously enriched in the typical H3K9me3 mark and in ...
Amandine Barral, Gabrielle Pozo, L. Ducrot, G. Papadopoulos, Sandrine Sauzet, A. Oldfield, Giacomo Cavalli, J. Déjardin   +7 more
semanticscholar   +1 more source

The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]

, 2015
RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core   +1 more source