Results 41 to 50 of about 75,723 (273)

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]

, 2009
HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild, RAFFA, GRAZIA DANIELA, Eskeland Ragnhild, Abel, Jochen, Jochen Abel, Raffa Grazia D., Raffa, Grazia D, Ragnhild Eskeland, Abel Jochen, Kremmer Elisabeth, Abel, J., Imhof Axel, Raffa, G.D., Ragnhild Eskel, Imhof, Axel, Eskeland, R., Grazia D. Raffa, Kremmer, E., Imhof, A., Kremmer, Elisabeth, Axel Imhof, Grazia D Raffa, Elisabeth Kremmer   +22 more
core   +1 more source

A simulation model of heterochromatin formation at submolecular detail

iScience, 2022
Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams, Yan Xiaokang, Nathaniel A. Hathaway, Dmitri Kireev   +3 more
doaj   +1 more source

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

eLife, 2016
Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions.
Joel M Swenson, Serafin U Colmenares, Amy R Strom, Sylvain V Costes, Gary H Karpen   +4 more
doaj   +1 more source

How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

Cells, 2020
Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj   +1 more source

Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2011
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
Bo O Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A Lenzmeier, Jin-Qiu Zhou   +6 more
doaj   +1 more source

Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes

Microbiology Spectrum, 2023
The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms.
Lucas Michel-Todó, Cristina Bancells, Núria Casas-Vila, Núria Rovira-Graells, Carles Hernández-Ferrer, Juan R. González, Alfred Cortés   +6 more
doaj   +1 more source

Heterochromatin as an Important Driver of Genome Organization

Frontiers in Cell and Developmental Biology, 2020
Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair.
Andrés Penagos-Puig, Mayra Furlan-Magaril   +1 more
doaj   +1 more source

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source

Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner [PDF]

, 2015
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses ...
Duan, Shili, Albert, Mareike, Peters, Antoine H. F. M., Kaustov, Lilia, Liu, Zichuan, Brykczynska, Urszula, Arrowsmith, Cheryl H., Tardat, Mathieu, Kunzmann, Rico, Thierry, Raphael   +9 more
core   +1 more source

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Cell Reports, 2021
Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska, R.A. Greenstein, Tamas Schauer, Karl C.F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al-Sady, Sigurd Braun   +7 more
doaj   +1 more source