Results 41 to 50 of about 102,384 (311)

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.

PLoS Genetics, 2023
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability.
Sarah MacKinnon, Viviane Pagé, Jennifer J Chen, Ali Shariat-Panahi, Ryan D Martin, Terence E Hébert, Jason C Tanny   +6 more
doaj   +1 more source

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Nature, 2017
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
A. Larson, D. Elnatan, Madeline M. Keenen, M. Trnka, J. B. Johnston, A. Burlingame, D. Agard, S. Redding, G. Narlikar   +8 more
semanticscholar   +1 more source

Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

Cell Reports, 2017
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren, Tomoko Noto, Kensuke Kataoka, Shan Gao, Yifan Liu, Kazufumi Mochizuki   +5 more
doaj   +1 more source

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

Cell, 2003
Cellular senescence is an extremely stable form of cell cycle arrest that limits the proliferation of damaged cells and may act as a natural barrier to cancer progression.
Masashi Narita, S. Nũnez, E. Heard, M. Narita, Athena W. Lin, Stephen A. Hearn, D. Spector, G. Hannon, S. Lowe   +8 more
semanticscholar   +1 more source

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

Molecules and Cells, 2020
Summary The formation of silenced and condensed heterochromatin foci involves enrichment of heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid droplets, but the biophysical principles underlying heterochromatin ...
Fabian Erdel, A. Rademacher, Rifka Vlijm, Jana Tünnermann, Lukas Frank, Robin Weinmann, Elisabeth Schweigert, Klaus Yserentant, J. Hummert, C. Bauer, Sabrina Schumacher, Ahmad Al Alwash, C. Normand, D. Herten, J. Engelhardt, K. Rippe   +15 more
semanticscholar   +1 more source

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell Reports, 2020
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance.
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin   +8 more
doaj   +1 more source

De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses

Viruses, 2021
The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive ...
Sara A. Dochnal, Alison K. Francois, Anna R. Cliffe   +2 more
doaj   +1 more source

Heterochromatin drives compartmentalization of inverted and conventional nuclei

Nature, 2019
The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2.
M. Falk, Y. Feodorova, N. Naumova, Maxim Imakaev, B. Lajoie, H. Leonhardt, B. Joffe, J. Dekker, G. Fudenberg, I. Solovei, L. Mirny   +10 more
semanticscholar   +1 more source

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Nature Biotechnology, 2021
Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-throughput, single-cell assessment of heterochromatin and its underlying genomic determinants remains challenging.
Martina Tedesco, Francesca Giannese, D. Lazarević, Valentina Giansanti, D. Rosano, Silvia Monzani, Irene Catalano, Elena Grassi, E. Zanella, O. Botrugno, Leonardo Morelli, Paola Panina Bordignon, G. Caravagna, A. Bertotti, G. Martino, L. Aldrighetti, S. Pasqualato, L. Trusolino, Davide Cittaro, G. Tonon   +19 more
semanticscholar   +1 more source

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
Freire-Benéitez, Veronica, Tarrant, Daniel, Buscaino, Alessia, Berman, Judith, Price, Robert Jordan   +4 more
core   +1 more source