Results 61 to 70 of about 81,802 (259)
Epigenetic plasticity safeguards heterochromatin configuration in mammals [PDF]
, 2023 Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In the mammalian nucleus, heterochromatin segregates from transcriptionally active genomic regions and exists ...
オカダ, ヤスシ +35 more
core
Advanced Science, EarlyView.Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu +12 more
wiley +1 more source
Early-replicating heterochromatin [PDF]
Genes & Development, 2003 Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast,Schizosaccharomyces pombe.
Soo-Mi, Kim +2 more
openaire +2 more sources
Nucleation and heterochromatin establishment in Drosophila miranda
, 2020 Heterochromatin is a key architectural feature of eukaryotic genomes, crucial for silencing of repetitive elements and maintaining genome stability. Heterochromatin shows stereotypical enrichment patterns around centromeres and repetitive sequences, but ...
Wei, Kevin
core +1 more source
Mechanisms of heterochromatin subnuclear localization. [PDF]
, 2013 Transcriptionally repressed heterochromatin becomes the dominant form of chromatin in most terminally differentiated cells. Moreover, in most cells, at least one class of heterochromatin is positioned adjacent to the nuclear lamina.
Towbin, Benjamin D +5 more
core +1 more source
Advanced Science, EarlyView.Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley +1 more source
RNAi and Heterochromatin Assembly [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The involvement of RNA interference (RNAi) in heterochromatin formation has become clear largely through studies in the fission yeast Schizosaccharomyces pombe and plants like Arabidopsis thaliana. This article discusses how heterochromatic small interfering RNAs are produced and how the RNAi machinery participates in the formation and function of ...
Robert, Martienssen, Danesh, Moazed
openaire +2 more sources
Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]
, 2009 HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild +22 more
core +1 more source
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu +12 more
wiley +1 more source
Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus.
PLoS ONECohesin mediates central features of chromosome architecture. The protein complex governs sister chromatid cohesion and organizes genomes into loops and domains.
Paul M Kraycer, Marc R Gartenberg
doaj +1 more source