Results 61 to 70 of about 102,384 (311)

MeCP2 links heterochromatin condensates and neurodevelopmental disease

Nature, 2020
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3.
Charles H. Li, Eliot L. Coffey, Alessandra Dall’Agnese, N. Hannett, Xin Tang, J. Henninger, J. Platt, Ozgur Oksuz, A. V. Zamudio, Lena K. Afeyan, Jurian Schuijers, X. Liu, S. Markoulaki, T. Lungjangwa, G. Leroy, Devon S. Svoboda, E. Wogram, Tong Ihn Lee, R. Jaenisch, R. Young   +19 more
semanticscholar   +1 more source

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Nature Communications, 2021
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms.
Thomas Montavon, N. Shukeir, Galina A. Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Y. Musa, Gerhard Mittler, A. G. Meyer, C. Genoud, T. Jenuwein   +10 more
semanticscholar   +1 more source

Mechanisms of heterochromatin subnuclear localization. [PDF]

, 2013
Transcriptionally repressed heterochromatin becomes the dominant form of chromatin in most terminally differentiated cells. Moreover, in most cells, at least one class of heterochromatin is positioned adjacent to the nuclear lamina.
Towbin, Benjamin D, Gasser, Susan M, Gonzalez-Sandoval, Adriana   +2 more
core   +1 more source

A simulation model of heterochromatin formation at submolecular detail

iScience, 2022
Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams, Yan Xiaokang, Nathaniel A. Hathaway, Dmitri Kireev   +3 more
doaj   +1 more source

Depletion of SAM leading to loss of heterochromatin drives muscle stem cell aging

Nature Metabolism
The global loss of heterochromatin during ageing has been observed in eukaryotes from yeast to humans, and this has been proposed as one of the causes of ageing.
Jeng-Min Kang, Daniel I. Benjamin, Soochi Kim, Jayesh S. Salvi, Gurkamal Dhaliwal, Richard Lam, Armon Goshayeshi, Jamie O Brett, Ling Liu, T. A. Rando   +9 more
semanticscholar   +1 more source

Confined migration induces heterochromatin formation and alters chromatin accessibility

bioRxiv, 2021
During migration, cells often squeeze through small constrictions, requiring extensive deformation. We hypothesized that the nuclear deformation associated with such confined migration could alter chromatin organization and function.
Chieh-Ren Hsia, Jawuanna McAllister, Ovais Hasan, Julius Judd, Seoyeon Lee, R. Agrawal, Chao-Yuan Chang, P. Soloway, J. Lammerding   +8 more
semanticscholar   +1 more source

The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

Genome Research, 2021
Heterochromatin remodeling is critical for various cell processes. In particular, the “loss of heterochromatin” phenotype in cellular senescence is associated with the process of aging and age-related disorders. Although biological processes of senescent
Xiang-Lin Zhang, Xuehui Liu, Zhenhai Du, Lei Wei, Huan Fang, Qiongye Dong, Jing Niu, Yanda Li, Juntao Gao, Michael Q. Zhang, Wei Xie, Xiaowo Wang   +11 more
semanticscholar   +1 more source

Heterochromatin: silence is golden [PDF]

Current Biology, 2003
Epigenetically heritable heterochromatin domains control a variety of chromosomal functions. In addition to stable repression of large pericentric and telomeric domains, heterochromatin plays an essential role in the maintenance of genomic integrity through its role in sister chromatin cohesion and chromosome segregation.
Elgin, Sarah C.R., Grewal, Shiv I.S.
openaire   +2 more sources

Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner [PDF]

, 2015
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses ...
Duan, Shili, Albert, Mareike, Peters, Antoine H. F. M., Kaustov, Lilia, Liu, Zichuan, Brykczynska, Urszula, Arrowsmith, Cheryl H., Tardat, Mathieu, Kunzmann, Rico, Thierry, Raphael   +9 more
core   +1 more source

Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes

Microbiology Spectrum, 2023
The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms.
Lucas Michel-Todó, Cristina Bancells, Núria Casas-Vila, Núria Rovira-Graells, Carles Hernández-Ferrer, Juan R. González, Alfred Cortés   +6 more
doaj   +1 more source