Results 61 to 70 of about 75,754 (257)

Heterochromatin Focuses on Senescence [PDF]

Molecular Cell, 2005
A key step in cellular senescence is the packaging of proliferation-promoting genes into repressive chromatin or heterochromatin. Recent work has described a novel histone component and mode of assembly of this senescence-associated heterochromatin.
Schulz, Laura, Tyler, Jessica
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1 [PDF]

, 2010
The histone methyltransferase SU(VAR)3-9 plays an important role in the formation of heterochromatin within the eukaryotic nucleus. Several studies have shown that the formation of condensed chromatin is highly regulated during development, suggesting ...
Johansen Kristen M., Boeke, Joern, Regnard Catherine, Peter B Becker, Kristen M Johansen, Weili Cai, Becker Peter B., Boeke Joern, Johansen Jørgen, Imhof Axel, Regnard, Catherine, Cai, Weili, Johansen, Jørgen, Imhof, Axel, Becker, Peter B., Joern Boeke, Johansen, Kristen M, Catherine Regnard, Axel Imhof, Jørgen Johansen, Cai Weili   +20 more
core   +1 more source

PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1 [PDF]

, 2014
[[abstract]]BACKGROUND: Proper re-establishment of heterochromatin after each round of DNA replication is critical to the preservation of cell identity. Paired box 3 (PAX3), a transcription factor important in embryonic development, was found to mediate ...
吳祖方;TSU-FANG, WU;姚雅莉;Yao, Ya-Li;賴羿如;LAI, I-LU;李宗翰;LEE, TSUNG-HAN;UNDE, D.ALAN;UNDERHILL, D.ALAN;楊文明;YANG, WEN-MING
core   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The Heterochromatin protein 1 (HP1) is involved in germline stem cells maintenance [PDF]

, 2013
HP1 (Heterochromatin Protein 1) is a nonhistone chromosomal protein first discovered in Drosophila melanogaster by its association with the heterochromatin and through mutations that suppressed the silencing effect of heterochromatin in position-effect ...
CASALE, ASSUNTA MARIA, PIACENTINI, Lucia, PIMPINELLI, Sergio, FANTI, Laura   +3 more
core  

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression [PDF]

, 2009
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Fan Hua-Ying, Kingston Robert E., Violaine Saint-André, Christian Muchardt, Saint-Andre, Violaine, Imhof Axel, Batsché Eric, Jang Suk Min, Kingston, Robert E., Saliha Azebi, Robert E Kingston, Axel Imhof, Jang, Suk Min, Eskeland, Ragnhild, Eskeland Ragnhild, Muchardt Christian, Eric Batsché, Azebi Saliha, Fan, Hua-Ying, Muchardt, Christian, Batsche, Eric, Hua-Ying Fan, Marc Lavigne, Ragnhild Eskeland, Saint-André Violaine, Imhof, Axel, Lavigne, Marc, Azebi, Saliha, Suk Min Jang, Lavigne Marc   +29 more
core   +1 more source

Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin, Nathalie Beaujean, Xavier Vignon, Yegor Vassetzky   +3 more
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source