Results 71 to 80 of about 81,802 (259)

HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression

Cell Death and Disease, 2021
High dietary sugar (HDS) is a modern dietary concern that involves excessive consumption of carbohydrates and added sugars, and increases the risk of metabolic disorders and associated cancers.
Che-Wei Chang, Yu-Chia Shen, Shian-Jang Yan   +2 more
doaj   +1 more source

Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster

, 2003
Heterochromatin has been traditionally regarded as a genomic wasteland, but in the last three decades extensive genetic and molecular studies have shown that this ubiquitous component of eukaryotic chromosomesmay perform important biological functions ...
CENCI, GIOVANNI, BELLONI, Giorgio, Nicoletta Corradini, D. E. Koryakov, DIMITRI, Patrizio, F. Rossi, VERNI', Fiammetta, I. F. Zhimulev   +7 more
core   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Chromatin state analysis of the barley epigenome reveals a higher-order structure defined by H3K27me1 and H3K27me3 abundance [PDF]

, 2015
This work was supported by grant BBSRC BB/I1022899/1 ‘The diversity and evolution of the gene component of the barley pericentromeric heterochromatin’.Combinations of histones carrying different covalent modifications are a major component of epigenetic ...
Dhillon, Taniya, Milne, Iain, Katie Baker, Baker, Katie, Colas, Isabelle, Taniya Dhillon, Micha Bayer, Bayer, Micha, Milne, Linda, Linda Milne, Flavell, Andrew J., Iain Milne, Andrew J. Flavell, Cook, Nicola, Nicola Cook, Isabelle Colas, Cook, Nicola; id_orcid   +16 more
core   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

A strategy for mapping the heterochromatin of chromosome 2 of Drosophila melanogaster

, 2003
The heterochromatin of chromosome 2 of Drosophila melanogaster has been among the best characterized models for functional studies of heterochromatin owing to its abundance of genetic markers. To determine whether it might also provide a favorable system
J. C. Yasuhara, MARCHETTI, Marcella, FANTI, Laura, PIMPINELLI, Sergio, B. T. Wakimoto   +4 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Correlative light and soft X-ray tomography of in situ mesoscale heterochromatin structure in intact cells

Scientific Reports
Heterochromatin organization is critical to many genome-related programs including transcriptional silencing and DNA repair. While super-resolution imaging, electron microscopy, and multiomics methods have provided indirect insights into the ...
Rajshikhar Gupta, Yagyik Goswami, Luezhen Yuan, Bibhas Roy, Eva Pereiro, GV Shivashankar   +5 more
doaj   +1 more source

Heterochromatin, from chromosome to protein [PDF]

, 2003
Deep insight on Heterochromatin, from chromosome to ...
Luciani, J, Mattei, MG
core   +1 more source