Results 81 to 90 of about 81,802 (259)

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1

, 2014
[[abstract]]BACKGROUND: Proper re-establishment of heterochromatin after each round of DNA replication is critical to the preservation of cell identity. Paired box 3 (PAX3), a transcription factor important in embryonic development, was found to mediate ...
吳祖方;TSU-FANG, WU;姚雅莉;Yao, Ya-Li;賴羿如;LAI, I-LU;李宗翰;LEE, TSUNG-HAN;UNDE, D.ALAN;UNDERHILL, D.ALAN;楊文明;YANG, WEN-MING
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Interaction between Polycomb and SSX Proteins in Pericentromeric Heterochromatin Function and Its Implication in Cancer

Cells, 2020
The stability of pericentromeric heterochromatin is maintained by repressive epigenetic control mechanisms, and failure to maintain this stability may cause severe diseases such as immune deficiency and cancer.
Simone Johansen, Morten Frier Gjerstorff   +1 more
doaj   +1 more source

The Heterochromatin protein 1 (HP1) is involved in germline stem cells maintenance

, 2013
HP1 (Heterochromatin Protein 1) is a nonhistone chromosomal protein first discovered in Drosophila melanogaster by its association with the heterochromatin and through mutations that suppressed the silencing effect of heterochromatin in position-effect ...
CASALE, ASSUNTA MARIA, PIACENTINI, Lucia, PIMPINELLI, Sergio, FANTI, Laura   +3 more
core  

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Epigenetic gene silencing by heterochromatin primes fungal resistance [PDF]

, 2020
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided the ...
Torres-Garcia, Sito, Yaseen, Imtiyaz, Pidoux, Alison, Audergon, Pauline N C B, White, Sharon, Allshire, Robin C., Shukla, Manu   +6 more
core   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

The EMBO Journal
Constitutive heterochromatin is essential for transcriptional silencing and genome integrity. The establishment of constitutive heterochromatin in early embryos and its role in early fruitfly development are unknown. Lysine 9 trimethylation of histone H3
Nazerke Atinbayeva, Iris Valent, Fides Zenk, Eva Loeser, Michael Rauer, Shwetha Herur, Piergiuseppe Quarato, Giorgos Pyrowolakis, Alejandro Gomez-Auli, Gerhard Mittler, Germano Cecere, Sylvia Erhardt, Guido Tiana, Yinxiu Zhan, Nicola Iovino   +14 more
doaj   +1 more source

Ectopic heterochromatin provides an alternative route to fungal resistance

Antifungal resistance in fungi, including the human pathogen Cryptococcus neoformans, commonly occurs via genetic mutations. However, the existence of unstable drug-resistant isolates suggests the possibility of epimutation-mediated resistance.
Yeboah, Rebecca
core   +1 more source