Results 81 to 90 of about 102,384 (311)

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

Protein & Cell, 2020
SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Shijia Bi, Zunpeng Liu, Zeming Wu, Ze-Hua Wang, Xiaoqian Liu, Si Wang, Jie Ren, Yan Yao, Weiqi Zhang, Moshi Song, Guang-Hui Liu, J. Qu   +11 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1 [PDF]

, 2010
The histone methyltransferase SU(VAR)3-9 plays an important role in the formation of heterochromatin within the eukaryotic nucleus. Several studies have shown that the formation of condensed chromatin is highly regulated during development, suggesting ...
Johansen Kristen M., Boeke, Joern, Regnard Catherine, Peter B Becker, Kristen M Johansen, Weili Cai, Becker Peter B., Boeke Joern, Johansen Jørgen, Imhof Axel, Regnard, Catherine, Cai, Weili, Johansen, Jørgen, Imhof, Axel, Becker, Peter B., Joern Boeke, Johansen, Kristen M, Catherine Regnard, Axel Imhof, Jørgen Johansen, Cai Weili   +20 more
core   +2 more sources

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

PLoS Genetics, 2022
The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood.
Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, Jeremy G Monroe, Yimeng Fang, Takenori Toda, Kristin S Koutmou, Kaushik Ragunathan, Chao Lu, Luke E Berchowitz, Songtao Jia   +11 more
doaj   +1 more source

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Nature Cell Biology, 2020
Following fertilization in mammals, the gametes are reprogrammed to create a totipotent zygote, a process that involves de novo establishment of chromatin domains.
Adam Burton, V. Brochard, Carmen Galán, Elias R. Ruiz-Morales, Q. Rovira, Diego Rodriguez-Terrones, Kai Kruse, S. Le Gras, Vishnu S. Udayakumar, H. Chin, André Eid, Xiaoyu Liu, Chenfei Wang, Shaorong Gao, S. Pradhan, Juan M. Vaquerizas, N. Beaujean, T. Jenuwein, M. Torres‐Padilla   +18 more
semanticscholar   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Position effect variegation (PEV) as an aging clock: visualization of age-dependent loss of heterochromatin and longevity associated with enhanced heterochromatin

Scientific Reports
The heterochromatin loss model of aging suggests there is an age-dependent reduction in epigenetic factors that form and maintain the heterochromatin state of chromosomes.
Sesley Tedeschi, Talia Takahashi, Yash Vyavahare, Emma Clark, Logan Deutschmann, Raynord Leung, Kat Stanley, Liam C. Hunt   +7 more
doaj   +1 more source

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance. [PDF]

Aging Cell
Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Wang J, Su Y, Chen C, Li Y, Han J, Du L, Zheng L, Dang YL, Peng Y.   +8 more
europepmc   +2 more sources

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2011
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
Bo O Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A Lenzmeier, Jin-Qiu Zhou   +6 more
doaj   +1 more source