Results 101 to 110 of about 102,384 (311)
Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source
HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression
Cell Death and Disease, 2021 High dietary sugar (HDS) is a modern dietary concern that involves excessive consumption of carbohydrates and added sugars, and increases the risk of metabolic disorders and associated cancers.
Che-Wei Chang +2 more
doaj +1 more source
Early-replicating heterochromatin [PDF]
Genes & Development, 2003 Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast,Schizosaccharomyces pombe.
Soo-Mi, Kim +2 more
openaire +2 more sources
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Nature Communications, 2020 In flowering plants, heterochromatin is demarcated by the histone variant H2A.W, elevated levels of the linker histone H1, and specific epigenetic modifications, such as high levels of DNA methylation at both CG and non-CG sites.
Pierre Bourguet +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
PRC2.1 Coordinates Peri-Nucleolar H3K27me3-Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity. [PDF]
Adv Sci (Weinh)PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Zhu L +12 more
europepmc +2 more sources
Heterochromatin: an epigenetic point of view in aging
Experimental and Molecular Medicine, 2020 Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism.
Jong-Hyuk Lee +3 more
semanticscholar +1 more source
Variation in telomeric heterochromatin in somaclones of rye
, 1992 Somaclonal variation in telomeric heterochromatin was detected by in situ hybridization with the het 1 probe, which hybridizes to a 380-bp repeated sequence family. In a control cultivar, Gazelle, large blocks of signal were detected at the telomeres but
Kaltsikes, P. J. +9 more
core +1 more source
Navigating heterochromatin [PDF]
, 2003 The condensed structure of heterochromatin differs significantly from euchromatin and DNA bound in heterochromatin is generally not transcriptionally active. Transcriptional silencing allows the control of gene expression and affords a novel mechanism of
Fuerst, Peter
core +1 more source