Results 121 to 130 of about 81,802 (259)
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
Screen to identify heterochromatin promoting drugs [PDF]
, 2014 Heterochromatin is a tightly packed form of DNA associated with gene silencing and plays a significant role in the regulation of gene expression, segregation of chromosomes during mitosis and protection of genome stability and integrity.
Loyola, Andre Christopher
core +1 more source
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair
Nature CommunicationsThe CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Feng Li +8 more
doaj +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
The YETI gene: from Drosophila melanogaster heterochromatin to human craniofacial development.
, 2011 In the present work, we have performed a functional analysis of CG40218, a heterochromatin gene encoding the YETI protein. YETI is a member of the evolutionarily conserved family of BCNT proteins whose function is still unclear.
F. R. Mariotti +9 more
core
The FEBS Journal, EarlyView.Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa +1 more
wiley +1 more source
Epigenetic control of cellular plasticity in breast cancer progression
The FEBS Journal, EarlyView.Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey +2 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract Chromosome organization and repetitive DNA distribution are important components of genome evolution in teleost fishes but remain poorly characterized in many species of ecological and conservation relevance. We performed a detailed cytogenetic analysis of the southern pygmy perch, Nannoperca australis, a small freshwater species widely used ...
Zuzana Majtánová +3 more
wiley +1 more source
iScienceSummary: Histone H3K9 methylated heterochromatin silences repetitive non-coding sequences and lineage-specific genes during development, but how tissue-specific genes escape from heterochromatin in differentiated cells is unclear.
Mi-Jin An +15 more
doaj +1 more source