Results 111 to 120 of about 81,802 (259)

Analysis of Heterochromatin-Associated Genomic Instability [PDF]

, 2009
Heterochromatin represents special regions in the genome that have been found to be prone to breakage and rearrangements in cancer cells. Through two separate but related projects on heterochromatin, this dissertation demonstrates the important role of ...
Wang, Yehong
core  

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Spatiotemporal Expression of ARRDC5 in Mammalian Spermatogenesis

Andrology, EarlyView.
ABSTRACT Background Spermiogenesis is the final phase of sperm development during which haploid round spermatids transform into specialized spermatozoa and occurs across distinct stages of sperm production in the seminiferous epithelium. Abnormalities in this process lead to malformations and an inability of sperm to fertilize eggs.
LeeLa D. Robinson, Jon M. Oatley
wiley   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair

Nucleus, 2019
Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Vadim O. Chagin, Britta Reinhart, Annette Becker, Oliver Mortusewicz, K. Laurence Jost, Alexander Rapp, Heinrich Leonhardt, M. Cristina Cardoso   +7 more
doaj   +1 more source

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

Cancer Science, EarlyView.
UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka, Yusuke Matsuno, Rika Kusumoto‐Matsuo   +2 more
wiley   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source

Fission yeast Caprin protein is required for efficient heterochromatin establishment.

PLoS Genetics
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Haidao Zhang, Ekaterina Kapitonova, Adriana Orrego, Christos Spanos, Joanna Strachan, Elizabeth H Bayne   +5 more
doaj   +1 more source

Chromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR–Cas9‐Mediated Knock‐In Efficiency

Cell Proliferation, EarlyView.
Histone modifications at CRISPR–Cas9‐induced DNA double‐strand breaks shape chromatin states and regulate DNA repair pathway choice. Transient epigenetic modulation may provide a promising strategy to enhance CRISPR–Cas9‐mediated gene knock‐in.
Xin Chen, Shan Qin, Ce Yang, Zhiyao Xing, Chong Liu, Xingchen Zhang, Xi Wu, Xueren Li, Yanhua Gong, Zichuan Liu   +9 more
wiley   +1 more source