Results 111 to 120 of about 102,384 (311)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

Nucleic Acids Research, 2020
Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is independent of its autophagy-related activity.
Hui-Fang Hu, Qian-Zhao Ji, Moshi Song, Jie Ren, Zunpeng Liu, Ze-Hua Wang, Xiaoqian Liu, K. Yan, Jian-Li Hu, Yao-Bin Jing, Si Wang, Weiqi Zhang, Guang-Hui Liu, J. Qu   +13 more
semanticscholar   +1 more source

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian, Sebastian Pünzeler (381339), Gunnar Schotta (116394), Jack, Antonia P. M., Michael Wells (381341), Bussemer, Silva, Martha Snyder (381340), Hake, Sandra B., Matthias Hahn, Irina Solovei, Solovei, Irina, Hahn, Matthias, Wells, Michael, Gunnar Schotta, Sebastian Pünzeler, Martha Snyder, Sandra B. Hake (165089), Matthias Hahn (209009), Antonia P. M. Jack (381337), Irina Solovei (85), Sandra B Hake, Silva Bussemer, Michael Wells, Antonia P M Jack, Silva Bussemer (381338), Gyorgyi Csankovszki (5654086), Snyder, Martha, Schotta, Gunnar, Csankovszki, Gyorgyi, Gyorgyi Csankovszki   +29 more
core   +2 more sources

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

Science, 2019
Reversing chromatin dynamics for development Compacted chromatin regions, marked by trimethylation of histone H3 at position lysine 9 (H3K9me3), occur at highly repeated DNA sequences, helping to suppress recombination and gene expression.
Dario Nicetto, G. Donahue, T. Jain, Tao Peng, Simone Sidoli, Li-Hong Sheng, Thomas Montavon, J. Becker, Jessica Grindheim, Kimberly R. Blahnik, B. Garcia, Kai Tan, R. Bonasio, T. Jenuwein, K. Zaret   +14 more
semanticscholar   +1 more source

RNA interference-mediated co-transcriptional gene silencing in fission yeast [PDF]

, 2012
In the last decade or so, RNA interference (RNAi) has gained unanticipated recognition in the fields of RNA biology and gene regulation. It exists in a wide variety of eukaryotic organisms, and various forms of RNAi are involved in diverse biological ...
Woolcock, Katrina Jane
core   +1 more source

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Science, 2019
How dipeptide repeats cause pathology A repeat expansion in the chromosome 9 open reading frame 72 (C9orf72) gene is the most common known cause of two neurodegenerative diseases: frontotemporal dementia and amyotrophic lateral sclerosis.
Yong-Jie Zhang, Lin Guo, Patrick K Gonzales, Tania F. Gendron, Yanwei Wu, Karen R. Jansen-West, Aliesha D O'Raw, Sarah R Pickles, M. Prudencio, Y. Carlomagno, M. Gachechiladze, Connor H. Ludwig, Ruilin Tian, Jeannie Chew, M. DeTure, Wen-Lang Lin, Jimei Tong, Lillian M. Daughrity, M. Yue, Yuping Song, Jonathan W. Andersen, M. Castanedes-Casey, Aishe Kurti, A. Datta, G. Antognetti, Alexander McCampbell, R. Rademakers, Björn E. Oskarsson, D. Dickson, M. Kampmann, Michael E. Ward, J. Fryer, C. Link, J. Shorter, L. Petrucelli   +34 more
semanticscholar   +1 more source

Proteomic interrogation of human chromatin. [PDF]

, 2011
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary, Christodoulos A Floudas, Floudas, Christodoulos A., Barry M Zee, Garcia, Benjamin A., Richard C Baliban, Baliban, Richard C., Sandra B Hake, Torrente, Mariana P., Zee, Barry M., Hake, Sandra B., Christodoulos A. Floudas, Barry M. Zee, Nicolas L. Young, Mariana P. Torrente, Gary LeRoy, Richard C. Baliban, Sandra B. Hake, Benjamin A. Garcia, Nicolas L Young, Benjamin A Garcia, Young, Nicolas L., Mariana P Torrente   +22 more
core   +2 more sources

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source