Results 91 to 100 of about 75,723 (273)

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1

, 2014
[[abstract]]BACKGROUND: Proper re-establishment of heterochromatin after each round of DNA replication is critical to the preservation of cell identity. Paired box 3 (PAX3), a transcription factor important in embryonic development, was found to mediate ...
吳祖方;TSU-FANG, WU;姚雅莉;Yao, Ya-Li;賴羿如;LAI, I-LU;李宗翰;LEE, TSUNG-HAN;UNDE, D.ALAN;UNDERHILL, D.ALAN;楊文明;YANG, WEN-MING
core   +1 more source

Oogenesis: Active Heterochromatin [PDF]

Current Biology, 2011
The genome of Drosophila is protected from DNA damage during oogenesis by a mechanism involving short RNAs. Surprisingly transcription of these RNAs requires that their DNA is associated with a histone modification usually associated with gene silencing.
openaire   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The Heterochromatin protein 1 (HP1) is involved in germline stem cells maintenance

, 2013
HP1 (Heterochromatin Protein 1) is a nonhistone chromosomal protein first discovered in Drosophila melanogaster by its association with the heterochromatin and through mutations that suppressed the silencing effect of heterochromatin in position-effect ...
CASALE, ASSUNTA MARIA, PIACENTINI, Lucia, PIMPINELLI, Sergio, FANTI, Laura   +3 more
core  

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

The EMBO Journal
Constitutive heterochromatin is essential for transcriptional silencing and genome integrity. The establishment of constitutive heterochromatin in early embryos and its role in early fruitfly development are unknown. Lysine 9 trimethylation of histone H3
Nazerke Atinbayeva, Iris Valent, Fides Zenk, Eva Loeser, Michael Rauer, Shwetha Herur, Piergiuseppe Quarato, Giorgos Pyrowolakis, Alejandro Gomez-Auli, Gerhard Mittler, Germano Cecere, Sylvia Erhardt, Guido Tiana, Yinxiu Zhan, Nicola Iovino   +14 more
doaj   +1 more source

Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster

, 2003
Heterochromatin has been traditionally regarded as a genomic wasteland, but in the last three decades extensive genetic and molecular studies have shown that this ubiquitous component of eukaryotic chromosomesmay perform important biological functions ...
CENCI, GIOVANNI, BELLONI, Giorgio, Nicoletta Corradini, D. E. Koryakov, DIMITRI, Patrizio, F. Rossi, VERNI', Fiammetta, I. F. Zhimulev   +7 more
core   +1 more source