Results 1 to 10 of about 9,816,038 (309)

Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling

Nature Communications
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory.
Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao   +13 more
doaj   +1 more source

Personalized transcriptional network analysis links age-related loss of gene coordination to individual biological aging

Genome Medicine
Background Aging is characterized by the decline in biological functions, accompanied by changes in gene-to-gene transcriptional coordination, which can be estimated by expression coordination in gene transcriptional network.
Hao-Tian Wang, Fu-Hui Xiao, Long Zhao, Qian Su, Tian-Rui Xia, Li-Qin Yang, Si-Yu Ma, Qing-Peng Kong   +7 more
doaj   +1 more source

ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia

Cell Reports Medicine
Summary: Ataxia-telangiectasia (A-T) is a hereditary neurodegenerative disorder caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Although existing rodent models reproduce some of the multi-systemic features of A-T, they notably fail ...
Kaiyu Xu, Ying Zhang, Yongxuan Chen, Xiaojia Zhu, Yu Li, Longbao Lv, Xiechao He, Zhengfei Hu, Yifan Li, Maosen Ye, Dewei Jiang, Zhanlong He, Weihua Jin, Yanyan Li, Xiaomei Yu, Deng-Feng Zhang, Karl Herrup, Ping Zheng, Yong-Gang Yao, Dong-Dong Wu, Jiali Li   +20 more
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Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Molecular Neurodegeneration
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation.
Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao   +4 more
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Comparative Efficiency of Multiple eDNA Sampling Methods for Monitoring Vertebrate Diversity in Mountainous Region

Environmental DNA
Monitoring biodiversity in mountain ecosystem biodiversity is vital for preserving these rapidly changing ecosystems, yet it remains challenging due to complex terrain and climate.
Yunyu Wang, Zichao Liu, Viorel Popescu, Zhaoli Ding, Xiaoyu Luo, Chunyan Yang, Guo‐Dong Wang   +6 more
doaj   +1 more source

Modelling Evolvability in Genetic Programming [PDF]

, 2016
We develop a tree-based genetic programming system capable of modelling evolvability during evolution through machine learning algorithms, and exploiting those models to increase the efficiency and final fitness. Existing methods of determining evolvability require too much computational time to be effective in any practical sense.
Benjamin Fowler, Wolfgang Banzhaf
openaire   +1 more source

Predicting extinction risk of gibbons from genomes of extinct Yunnan lar gibbon

Genome Biology
Background All species of gibbons are endangered, with the Yunnan lar gibbons (Hylobates lar yunnanensis) officially declared extinct in the wild in 2022. While human activities are frequently cited as major factor, the population structure, evolutionary
Ayun Luo, Hang-Yu Tian, Song Li, Christian Roos, Sheng Wang, Dong-Dong Wu   +5 more
doaj   +1 more source

Genetic models of vasopressin deficiency [PDF]

Experimental Physiology, 2000
Animal models of genetic hormone deficiency are useful as models for physiological studies of hormone deficiency and hormone action. Structure—function studies of the specific underlying gene defect may help in understanding mechanisms regulating gene expression and secretion of the peptide product. Spontaneous genetic models of vasopressin deficiency,
openaire   +2 more sources

The effects of runs-of-homozygosity on pig domestication and breeding

BMC Genomics
Background Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs.
Lin Tao, Hang Liu, Adeniyi C. Adeola, Hai-Bing Xie, Shu-Tang Feng, Ya-Ping Zhang   +5 more
doaj   +1 more source

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

Nature Communications
Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates.
Juan Meng, Cheng Chen, Zhiyong Zhu, Yongkang Sun, Yiming Huang, Kaijie Hu, Jiqiang Fu, Luyan Wu, Ling Li, Yiqin Bai, Tianyi Fei, Zhen Liu, Chao Li, Zhiming Shen, Longqi Liu, Chengyu Li, Tao Song, Cirong Liu, Muming Poo, Shiping Liu, Ying Lei, Yidi Sun   +21 more
doaj   +1 more source