Results 1 to 10 of about 1,516,599 (318)
A Genetic Model of the Connectome [PDF]
Neuron, 2020 The connectomes of organisms of the same species show remarkable architectural and often local wiring similarity, raising the question: where and how is neuronal connectivity encoded? Here, we start from the hypothesis that the genetic identity of neurons guides synapse and gap-junction formation and show that such genetically driven wiring predicts ...
Barabási, Dániel L. +1 more
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Genetic risks and genetic model specification [PDF]
Journal of Theoretical Biology, 2016 Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy ...
Gang, Zheng +5 more
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Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions [PDF]
Diabetes & Metabolism Journal, 2022 Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies.
Md Jakir Hossain +4 more
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Genetics in non-genetic model systems [PDF]
Current Opinion in Neurobiology, 2012 The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C.
Lois, Carlos, Groves, James O.
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Genetic Inheritance Models of Non-Syndromic Cleft Lip with or without Palate: From Monogenic to Polygenic [PDF]
, 2023 Non-syndromic cleft lip with or without palate (NSCL/P) is a prevalent birth defect that affects 1/500–1/1400 live births globally. The genetic basis of NSCL/P is intricate and involves both genetic and environmental factors. In the past few years,
Fengzhou Du +3 more
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Frontiers in Endocrinology, 2023 ObjectiveTo investigate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN).MethodsA total of 77 patients with IMN diagnosed in both our hospital and other hospitals were included in this study; the patients were divided
Ping Chen +15 more
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Genetic Models of Migraine [PDF]
Archives of Neurology, 2007 Migraine is a common, disabling, complex brain disorder, presenting in attacks that may have up to 3 phases: a prodromal phase, the aura phase, and the headache phase. The pathogenesis of the aura and headache phases is reasonably well understood, but the mechanism by which migraine attacks are triggered is unknown.
Rob C G, van de Ven +5 more
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Genetic models of fibrillinopathies
GENETICS, 2023 Abstract The fibrillinopathies represent a group of diseases in which the 10–12 nm extracellular microfibrils are disrupted by genetic variants in one of the genes encoding fibrillin molecules, large glycoproteins of the extracellular matrix. The best-known fibrillinopathy is Marfan syndrome, an autosomal dominant condition affecting the
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A MODEL FOR THE GENETICS OF HANDEDNESS [PDF]
Genetics, 1972 ABSTRACT Experimental data and theoretical work on the inheritance of handedness and cerebral dominance are reviewed. A two-gene, four-allele model, one locus pertaining to left or right hemispheric dominance and the other to contralateral or ipsilateral hand control relative to the dominant hemisphere, is constructed. It is in excellent
J, Levy, T, Nagylaki
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Statistical validation of genetic models [PDF]
, 2001 Various aspects of statistical validation of genetic models are reviewed. Possible ways of decomposing additive genetic variance over time and ways of comparing predictions at different times are suggested.
Robin Thompson, Thompson, R.
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