Results 31 to 40 of about 158,650 (268)

Single-cell expression profiling of bat wing development

open access: yesNature Communications
Bats are the only true-flight mammals, with wings formed by elongated digits and wing membranes. Despite the uniqueness, the cellular and molecular aspects of bat wing development remain largely unknown. Here, we use single-cell transcriptomic sequencing
Xue Lyu   +7 more
doaj   +1 more source

Metabolic Adaptation to Following Temperature Acclimation in Fish on the Yun-Gui Plateau

open access: yesBiology
Temperature is crucial for fish physiology, as metabolism and related physiological processes are directly influenced by thermal energy. Against the backdrop of global warming, climate-induced variations in water temperature increasingly constrain fish ...
Wei Dao   +9 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

An Accurate Model for Genetic Hitchhiking [PDF]

open access: yesGenetics, 2008
AbstractWe suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and ...
Eriksson, A.   +3 more
openaire   +3 more sources

Regional and aging-specific cellular architecture of non-human primate brains

open access: yesGenome Medicine
Background Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain ...
Yun-Mei Wang   +15 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

DNA replication fork speed acts as a pacer in cortical neurogenesis

open access: yesNature Communications
DNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored.
Jianhong Wang   +6 more
doaj   +1 more source

Weighting factors of sire daughter information in international genetic evaluations [PDF]

open access: yes, 2001
International genetic evaluations of dairy bulls are currently based on national genetic evaluation results. Total number of daughters in a country is used to weight national information, but may not optimally reflect the precision of a sire's daughter ...
Fikse, WF, Banos, G
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman   +7 more
wiley   +1 more source

Stochastic modelling of Genetic Algorithms

open access: yesArtificial Intelligence, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
David Reynolds, Jagannathan Gomatam
openaire   +2 more sources

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