Results 21 to 30 of about 1,516,599 (318)

Genetic algorithms for the generation of models with micropopulations [PDF]

, 2003
Proceedings of: EvoWorkshops 2003: EvoBIO, EvoCOP, EvoIASP, EvoMUSART, EvoROB, and EvoSTIM Essex, UK, April 14–16, 2003The present article puts forward a method for an interactive model generation through the use of Genetic Algorithms applied to small ...
Sáez, Yago, Segovia, Javier, Sáez Achaerandio, Yago, Sanjuan, Óscar, Isasi, Pedro, Isasi Viñuela, Pedro   +5 more
core   +1 more source

Joint Modeling of Imaging and Genetics [PDF]

, 2013
We propose a unified Bayesian framework for detecting genetic variants associated with a disease while exploiting image-based features as an intermediate phenotype. Traditionally, imaging genetics methods comprise two separate steps. First, image features are selected based on their relevance to the disease phenotype.
Nematollah Batmanghelich, Adrian V. Dalca, Mert R. Sabuncu, Polina Golland   +3 more
openaire   +2 more sources

Genetic model misspecification in genetic association studies [PDF]

BMC Research Notes, 2017
The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
openaire   +3 more sources

On Flexible finite polygenic models for multiple-trait evaluation [PDF]

, 2002
Finite polygenic models (FPM) might be an alternative to the infinitesimal model (TIM) for the genetic evaluation of pedigreed multiple-generation populations for multiple quantitative traits.
Bink, M.C.A.M.
core   +1 more source

Genetic influences on exercise participation in 37.051 twin pairs from seven countries [PDF]

, 2006
Background A sedentary lifestyle remains a major threat to health in contemporary societies. To get more insight in the relative contribution of genetic and environmental influences on individual differences in exercise participation, twin samples from ...
Hunkin, J, Boomsma, Dorret I, Spector Tim D., Kaprio J, Nicholas G. Martin, Martin NG, Harris, Jennifer R., de Geus, Eco J. C, Belinda K. Cornes, Rose, Richard J., Eco J. C. De Geus, de Geus, E.J.C., Stubbe JH, Dorret I. Boomsma, Richard J, Harris JR, Stubbe Janine H., Kyvik, KO, Rose RJ, Pedersen, Nancy L., Martin, N.G., de Geus EJ, Tim D Spector, de Geus Eco J.C., Boomsma, Dorret I., Pedersen, Nancy L, Nancy L Pedersen, Cornes, Belinda K, Kaprio, Jaakko, Skytthe A, Martin, Nicholas G., Stubbe, Janine H., Kyvik, K., Vink, JM, Hunkin Janice, Rose, Richard J, Rose, RJ, Jacqueline M. Vink, Vink JM, Skytthe, Axel, Pedersen NL, Dorret I Boomsma, Vink, J.M., Hunkin, J., Vink, Jacqueline M., de Geus, EJC, Kujala, Urho M, Jennifer R Harris, Kyvik KO, Boomsma DI, Boomsma, DI, Kujala UM, Cornes, Belinda K., Kaprio, J., Kyvik, Kirsten O., Richard J Rose, Jennifer R. Harris, Axel Skytthe, Spector, Tim D, Nancy L. Pedersen, Rose Richard J., Kujala, UM, Stubbe, JH, Skytthe, A, Eco J C de Geus, Kirsten O. Kyvik, Kyvik Kirsten O., Harris Jennifer R., Janice Hunkin, Boomsma Dorret I., Skytthe Axel, Vink Jacqueline M., Spector TD, Kirsten O Kyvik, Kujala, U., Kaprio Jaakko, Stubbe, Janine H, Pedersen, N.L., Martin, NG, Kujala, Urho M., Cornes Belinda K., Urho M. Kujala, Harris, Jennifer R, Spector, T.D., Jaakko Kaprio, Pedersen, NL, Stubbe, J.H., Boomsma, D.I., Martin Nicholas G., Cornes BK, Tim D. Spector, de Geus, E.J.C.; id_orcid, de Geus, EJ, Harris, JR, Vink, Jacqueline M, Kyvik, Kirsten O, Cornes, B., Belinda K Cornes, Urho M Kujala, Rose, R.J., Spector, Tin D., Skytthe, A., Pedersen Nancy L., Martin, Nicholas G, Kaprio, J, Janine H Stubbe, Cornes, BK, De Geus, Eco J. C., Hunkin J, Nicholas G Martin, Jacqueline M Vink, Spector, TD, Hunkin, Janice, Boomsma, D.I.; id_orcid, Harris, J.R., Janine H. Stubbe, Kujala Urho M.   +116 more
core   +1 more source

Genetic prediction of male pattern baldness based on large independent datasets [PDF]

, 2023
Genetic prediction of male pattern baldness (MPB) is important in science and society. Previous genetic MPB prediction models were limited by sparse marker coverage, small sample size, and/or data dependency in the different analytical steps.
Maj, Carlo, Spector, Timothy D., Hysi, Pirro, Heilmann-Heimbach, Stefanie, Kayser, Manfred, Chen, Yan, Liu, Fan   +6 more
core   +1 more source

On using surrogates with genetic programming [PDF]

, 2014
One way to accelerate evolutionary algorithms with expensive fitness evaluations is to combine them with surrogate models. Surrogate models are efficiently computable approximations of the fitness function, derived by means of statistical or machine ...
Branke, Jürgen, Hildebrandt, Torsten
core   +1 more source

Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background [PDF]

, 2021
Down syndrome (DS), trisomy of the long arm of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability (ID). Currently, there are no effective pharmacotherapies. The success of clinical trials to improve cognition depends
Aaron Block, Katheleen J. Gardiner, Md. Mahiuddin Ahmed, Nicolas Busquet   +3 more
core   +1 more source

Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

Nature Communications
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals,
Haili Shao, Jipeng Huang, Hui Wang, Guolei Wang, Xu Yang, Mei Cheng, Changjie Sun, Li Zou, Qin Yang, Dandan Zhang, Zhen Liu, Xuelong Jiang, Lei Shi, Peng Shi, Baowei Han, Baowei Jiao   +15 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source