Results 21 to 30 of about 28,946,101 (334)
SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model
bioRxiv, 2018 With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology.
B. Haller, Philipp W. Messer
semanticscholar +1 more source
Controlling the Overfitting of Heritability in Genomic Selection through Cross Validation. [PDF]
, 2017 In genomic selection (GS), all the markers across the entire genome are used to conduct marker-assisted selection such that each quantitative trait locus of complex trait is in linkage disequilibrium with at least one marker.
Jia, Zhenyu
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Toward more predictive genetic mouse models of Alzheimer's disease.
Brain Research Bulletin, 2016 Genetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations
Kristen D. Onos +3 more
semanticscholar +1 more source
The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]
, 2003 The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
core +4 more sources
Alternate Service Delivery Models in Cancer Genetic Counseling: A Mini-Review
Frontiers in Oncology, 2016 Demand for cancer genetic counseling has grown rapidly in recent years as germline genomic information has become increasingly incorporated into cancer care, and the field has entered the public consciousness through high-profile celebrity publications ...
A. Buchanan, A. Rahm, Janet L. Williams
semanticscholar +1 more source
Scientific Reports, 2022 Group sizes in an animal study are calculated from estimates on variation, effect, power and significance level. Much of the variation in glucose related parameters of the diet-induced obese (DIO) mouse model is due to inter-individual variation in gut ...
Valeriia Bondarenko +9 more
doaj +1 more source
Genetics of fat storage in flies and worms: what went wrong? [PDF]
, 2011 Body weight and fat storage are strongly influenced by an individual’s genetic makeup. In humans, genetic polymorphisms have been identified that have effects on body mass index (BMI) and fat content (Meyre et al., 2009; Speliotes et al., 2010; Choquet ...
Al-Anzi, Bader, Zinn, Kai
core +3 more sources
Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer
, 2006 We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution.
J. Maynard +4 more
core +1 more source
Misspecification in mixed-model based association analysis
, 2015 Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers.
Kruijer, Willem
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Gene-history correlation and population structure [PDF]
, 2004 Correlation of gene histories in the human genome determines the patterns of genetic variation (haplotype structure) and is crucial to understanding genetic factors in common diseases.
Eriksson A Mehlig B +18 more
core +2 more sources