Results 11 to 20 of about 28,946,101 (334)
Multivariate Survival Mixed Models for Genetic Analysis of Longevity Traits [PDF]
, 2014 A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications.
Labouriau, Rodrigo +2 more
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Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Genome Research, 2003 Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework.
P. Shannon +8 more
semanticscholar +1 more source
Genetic algorithms for the generation of models with micropopulations [PDF]
, 2003 Proceedings of: EvoWorkshops 2003: EvoBIO, EvoCOP, EvoIASP, EvoMUSART, EvoROB, and EvoSTIM Essex, UK, April 14–16, 2003The present article puts forward a method for an interactive model generation through the use of Genetic Algorithms applied to small ...
Isasi, Pedro +3 more
core +3 more sources
Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
openaire +3 more sources
Cancers, 2018 The combination of increased referral for genetic testing and the current shortage of genetic counselors has necessitated the development and implementation of alternative models of genetic counseling and testing for hereditary cancer assessment.
J. McCuaig +5 more
semanticscholar +1 more source
Genetic models of fibrillinopathies
GENETICS, 2023 Abstract The fibrillinopathies represent a group of diseases in which the 10–12 nm extracellular microfibrils are disrupted by genetic variants in one of the genes encoding fibrillin molecules, large glycoproteins of the extracellular matrix. The best-known fibrillinopathy is Marfan syndrome, an autosomal dominant condition affecting the
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Animal models with group-specific additive genetic variances: extending genetic group models [PDF]
Genetics Selection Evolution, 2018 Abstract1.Theanimal modelis a key tool in quantitative genetics and has been used extensively to estimate fundamental parameters, such as additive genetic variance, heritability, or inbreeding effects. An implicit assumption of animal models is that all founder individuals derive from a single population.
Muff, Stefanie +4 more
openaire +7 more sources
Combining polynomial chaos expansions and genetic algorithm for the coupling of electrophysiological models [PDF]
, 2019 The number of computational models in cardiac research has grown over the last decades. Every year new models with di erent assumptions appear in the literature dealing with di erences in interspecies cardiac properties.
A Mahajan +17 more
core +2 more sources
Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]
, 2013 To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core +1 more source
Genetic compensation triggered by mutant mRNA degradation
Nature, 2019 Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation,
Mohamed A. El-Brolosy +13 more
semanticscholar +1 more source