The TUBG meshwork is associated with centromere dynamics and micronuclear organization [PDF]
Communications BiologyThis study investigates how γ-tubulin and the centrosome contribute to interphase centromere dynamics and nuclear organization. Although classically associated with mitotic microtubule nucleation, here we show that γ-tubulin associates with chromatin and
Alaaddin Muteb +2 more
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Parallel Pathways for Recruiting Effector Proteins Determine Centromere Drive and Suppression
Cell, 2021 Summary Selfish centromere DNA sequences bias their transmission to the egg in female meiosis. Evolutionary theory suggests that centromere proteins evolve to suppress costs of this “centromere drive”.
Derek J Stefanik +2 more
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Only the Rye Derived Part of the 1BL/1RS Hybrid Centromere Incorporates CENH3 of Wheat
Frontiers in Plant Science, 2021 The precise assembly of the kinetochore complex at the centromere is epigenetically determined by substituting histone H3 with the centromere-specific histone H3 variant CENH3 in centromeric nucleosomes.
Raheleh Karimi-Ashtiyani +3 more
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Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
eLife, 2020 Although originally thought to be silent chromosomal regions, centromeres are instead actively transcribed. However, the behavior and contributions of centromere-derived RNAs have remained unclear.
Leah Bury +5 more
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Centromeric retrotransposons and centromere function.
Current Opinion in Genetics & Development, 2018 The centromeric DNA of most multicellular eukaryotes consists of tandem repeats (TR) that bind centromere-specific proteins and act as a substrate for the efficient repair of frequent double-stranded DNA breaks. Some retrotransposons target active centromeres during integration with such specificity that they can be used to deduce current and historic ...
Gernot G. Presting
semanticscholar +3 more sources
Unconventional centromere architectures in Tapirus indicus reveal hotspots for satellite-free centromere formation in Perissodactyla [PDF]
Communications BiologyCentromeres, the chromosomal loci responsible for segregation during cell division, play a key role in genome evolution and speciation. While centromere function is highly conserved and epigenetically defined by CENP-A, the underlying DNA sequences are ...
Marialaura Biundo +6 more
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Pan-centromere reveals widespread centromere repositioning of soybean genomes
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Centromeres are crucial for ensuring accurate chromosome segregation in eukaryotic organisms. We identified centromere satellites associated with chromosome 1 of soybean, revealing significant rearrangements and impacting the localization of
Yang Liu +11 more
semanticscholar +1 more source
Two Gap-free Reference Genomes and a Global View of the Centromere Architecture in Rice.
Molecular Plant, 2021 Rice (Oryza sativa), a major staple throughout the world and a model system for plant genomics and breeding, was the first crop genome sequenced almost two decades ago.
Jia-Ming Song +24 more
semanticscholar +1 more source
Centromere Identity and the Regulation of Chromosome Segregation
Frontiers in Cell and Developmental Biology, 2022 Eukaryotes segregate their chromosomes during mitosis and meiosis by attaching chromosomes to the microtubules of the spindle so that they can be distributed into daughter cells.
Kousik Sundararajan, A. Straight
semanticscholar +1 more source
Diverse mechanisms of centromere specification
Current Biology, 2021 Summary The centromere performs a universally conserved function, to accurately partition genetic information upon cell division. Yet, centromeres are among the most rapidly evolving regions of the genome and are bound by varying assortments of ...
B. Mellone, D. Fachinetti
semanticscholar +1 more source