Results 1 to 10 of about 87,751 (339)
Stretching the rules: monocentric chromosomes with multiple centromere domains. [PDF]
PLoS Genetics, 2012 The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3.
Pavel Neumann +8 more
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EWSR1 maintains centromere identity
Cell Reports, 2023 Summary: The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere identity.
Risa Kitagawa +4 more
doaj +2 more sources
Chromosome Y centromere array deletion leads to impaired centromere function. [PDF]
PLoS ONE, 2014 The centromere is an essential chromosomal structure that is required for the faithful distribution of replicated chromosomes to daughter cells. Defects in the centromere can compromise the stability of chromosomes resulting in segregation errors.
Alison N Graham, Paul Kalitsis
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Centromere Repositioning [PDF]
Genome Research, 1999 Primate pericentromeric regions recently have been shown to exhibit extraordinary evolutionary plasticity. In this paper we report an additional peculiar feature of these regions that we discovered while analyzing, by FISH, the evolutionary conservation of primate phylogenetic chromosome IX.
Montefalcone G +3 more
openaire +3 more sources
RB dependent transcriptional regulation at mitotic centromeres preserves genome stability [PDF]
Life Science AllianceLoss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. Transcripts derived from centromere repeats play a critical role in the localization and activity of kinetochore components ...
Elizabeth A Crowley, Amity L Manning
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Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
eLife, 2020 Although originally thought to be silent chromosomal regions, centromeres are instead actively transcribed. However, the behavior and contributions of centromere-derived RNAs have remained unclear.
Leah Bury +5 more
doaj +2 more sources
Centromere domain organization and histone modifications [PDF]
Brazilian Journal of Medical and Biological Research, 2002 Centromere function requires the proper coordination of several subfunctions, such as kinetochore assembly, sister chromatid cohesion, binding of kinetochore microtubules, orientation of sister kinetochores to opposite spindle poles, and their movement ...
P. Bjerling, K. Ekwall
doaj +2 more sources
Cell Reports, 2018 Summary: The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae.
Wenjuan Zhang +2 more
exaly +3 more sources
Chromosome ResCentromeres are fundamental chromosomal structures that ensure accurate chromosome segregation during cell division. Despite their conserved and essential role in maintaining genomic stability, centromeres are subject to rapid evolutionary change. At the heart of centromere identity is the histone H3 variant CENP-A, an epigenetic mark that defines and ...
Enriquez A, Nechemia-Arbely Y.
europepmc +4 more sources
Nature Communications, 2017 Faithful chromosome segregation during mitosis requires that the kinetochores of all sister chromatids become stably connected to microtubules derived from opposite spindle poles.
Rutger C. C. Hengeveld +4 more
semanticscholar +2 more sources