Stretching the rules: monocentric chromosomes with multiple centromere domains. [PDF]
PLoS Genetics, 2012 The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3.
Pavel Neumann +8 more
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RB dependent transcriptional regulation at mitotic centromeres preserves genome stability [PDF]
Life Science AllianceLoss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. Transcripts derived from centromere repeats play a critical role in the localization and activity of kinetochore components ...
Elizabeth A Crowley, Amity L Manning
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Kinetochore mutations and histone phosphorylation pattern changes accompany holo- and macro-monocentromere evolution [PDF]
Nature CommunicationsCentromeres are essential for kinetochore assembly and spindle attachment. While chromosomes of most species are monocentric with a single centromere, a minority exhibit holocentricity, with a centromere along the chromatid length.
Yi-Tzu Kuo +12 more
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Only the Rye Derived Part of the 1BL/1RS Hybrid Centromere Incorporates CENH3 of Wheat
Frontiers in Plant Science, 2021 The precise assembly of the kinetochore complex at the centromere is epigenetically determined by substituting histone H3 with the centromere-specific histone H3 variant CENH3 in centromeric nucleosomes.
Raheleh Karimi-Ashtiyani +3 more
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Current Biology, 2016 Centromeres, chromosomal regions that become physically linked to the spindle during cell division, ensure equal division of genetic material between daughter cells. They are ubiquitous and essential in eukaryotic life. In this primer, we ask the questions 'What defines a functional centromere?' and 'What do all centromeres have in common?' To address ...
Lisa E, Kursel, Harmit S, Malik
openaire +2 more sources
Cenh3: An Emerging Player in Haploid Induction Technology. [PDF]
, 2016 True-breeding lines are required for the development and production of crop varieties. In a classical breeding approach these lines are obtained through inbreeding, and often 7-9 generations of inbreeding is performed to achieve the desired level of ...
Britt, Anne B, Kuppu, Sundaram
core +7 more sources
The cotton centromere contains a Ty3-gypsy-like LTR retroelement. [PDF]
PLoS ONE, 2012 The centromere is a repeat-rich structure essential for chromosome segregation; with the long-term aim of understanding centromere structure and function, we set out to identify cotton centromere sequences. To isolate centromere-associated sequences from
Song Luo +7 more
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EWSR1 maintains centromere identity
Cell Reports, 2023 Summary: The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere identity.
Risa Kitagawa +4 more
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A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila. [PDF]
PLoS ONE, 2012 The relationship between the nucleolus and the centromere, although documented, remains one of the most elusive aspects of centromere assembly and maintenance.
Chin-Chi Chen +3 more
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Variation in the CENP-A sequence association landscape across diverse inbred mouse strains
Cell Reports, 2023 Summary: Centromeres are crucial for chromosome segregation, but their underlying sequences evolve rapidly, imposing strong selection for compensatory changes in centromere-associated kinetochore proteins to assure the stability of genome transmission ...
Uma P. Arora +2 more
doaj +1 more source