Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]
, 2009 Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
core +1 more source
The inner-centromere is a biomolecular condensate scaffolded by the Chromosomal Passenger Complex
Nature Cell Biology, 2019 The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
Prasad D. Trivedi +5 more
semanticscholar +1 more source
Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]
, 1998 The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul +8 more
core +1 more source
Atypical centromeres in plants – what they can tell us
Frontiers in Plant Science, 2015 The centromere, visible as the primary constriction of condensed metaphase chromosomes, is a defined chromosomal locus essential for genome stability. It mediates transient assembly of a multi-protein complex, the kinetochore, which enables interaction ...
Maria eCuacos +2 more
doaj +1 more source
Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. [PDF]
PLoS Genetics, 2018 Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere
Jinpu Yang +7 more
doaj +1 more source
Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes[OPEN]
The Plant Cell, 2019 Variation in centromere satellite sequence and copy number, and structural rearrangements produce asymmetries in polyploid wheat homeologs, highlighting the role in homolog pairing during meiosis. Centromeres mediate the pairing of homologous chromosomes
Han-Dong Su +5 more
semanticscholar +1 more source
Comparative gene mapping in Arabidopsis lyrata chromosomes 1 and 2 and the corresponding A. thaliana chromosome 1: recombination rates, rearrangements and centromere location [PDF]
, 2006 To add detail to the genetic map of Arabidopsis lyrata, and compare it with that of A. thaliana, we have developed many additional markers in the A. lyrata linkage groups, LG1 and LG2, corresponding to A. thaliana chromosome 1.
Preuss, S +4 more
core +1 more source
m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells.
Cellm6A modification is best known for its critical role in controlling multiple post-transcriptional processes of the mRNAs. Here, we discovered elevated levels of m6A modification on centromeric RNA (cenRNA) in cancerous cells compared with non-cancerous ...
Zi-Ho Kang +15 more
semanticscholar +1 more source
The molecular basis for centromere identity and function
Nature reviews. Molecular cell biology, 2015 The centromere is the region of the chromosome that directs its segregation in mitosis and meiosis. Although the functional importance of the centromere has been appreciated for more than 130 years, elucidating the molecular features and properties that ...
Kara L. McKinley, I. Cheeseman
semanticscholar +1 more source
Nature Cell Biology, 2019 Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase ...
Yael Nechemia-Arbely +9 more
semanticscholar +1 more source