Results 1 to 10 of about 105,994 (204)

Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution

Frontiers in Cell and Developmental Biology, 2022
The assembly of a functional kinetochore on centromeric chromatin is necessary to connect chromosomes to the mitotic spindle, ensuring accurate chromosome segregation.
Shreyas Sridhar, Tatsuo Fukagawa
doaj   +1 more source

Cell cycle control of kinetochore assembly

Nucleus, 2022
The kinetochore is a large proteinaceous structure assembled on the centromeres of chromosomes. The complex machinery links chromosomes to the mitotic spindle and is essential for accurate chromosome segregation during cell division.
Qianhua Dong, Fei Li
doaj   +1 more source

A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]

PLoS Genetics, 2012
Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
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Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex

Frontiers in Cellular and Infection Microbiology, 2021
Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules.
Lorenzo Brusini, Lorenzo Brusini, Simon D’Archivio, Simon D’Archivio, Jennifer McDonald, Jennifer McDonald, Bill Wickstead   +6 more
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Biochemical evidence for diverse strategies in the inner kinetochore [PDF]

Open Biology, 2020
The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore.
G. E. Hamilton, T. N. Davis
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The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein. [PDF]

PLoS Genetics, 2013
The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to
Bungo Akiyoshi, Christian R Nelson, Nicole Duggan, Steven Ceto, Jeffrey A Ranish, Sue Biggins   +5 more
doaj   +1 more source

Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex [PDF]

, 2012
Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process.
Bancroft, James M., Cardoso, M. Cristina, Deng, Wen, Diekmann, Stephan, Döring, Volker, Emmerth, Stephan, Eskat, Anja, Hellwig, Daniela, Hofmeister, Antje, Hoischen, Christian, Leonhardt, Heinrich, McAinsh, Andrew D., Meraldi, Patrick, Rudolphi, Sven, Ulbricht, Tobias   +14 more
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Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I [PDF]

, 2013
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
A Petrovic, A Toth, AL Marston, AP Joglekar, C Michaelis, C Rumpf, E Screpanti, Eva Hoffmann, GW Kerr, GW Kerr, IL Brito, J Fernius, J Gregan, J Huang, J Matos, J Wong, Jacob Z. Dalgaard, Jonathan B. A. Millar, K Johzuka, K Tada, K Tanaka, KD Corbett, KD Corbett, KP Rabitsch, Louise Newnham, M Petronczki, M Petronczki, MR Przewloka, N Grandin, P Hieter, P Hornung, Prakash Arumugam, Rajesh T. Shenoy, RK Clyne, S Keeney, S Santaguida, S Westermann, SB Buonomo, Sourav Sarkar, Sue Biggins, X Li   +40 more
core   +8 more sources

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]

, 2020
Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan, Andrew D. McAinsh, Auckland, Bancroft, Baumbach, Berto, Berto, Bolhy, Bomont, Chan, Ciossani, Currie, DeSantis, Dix, Dudka, Emanuele Roscioli, Etemad, Faulkner, Feng, Filges, Gama, Gassmann, Gutierrez, Haley, Helena Louise Elvidge Coker, Helgeson, Hoffman, Holt, Howell, Huang, Huis In ’t Veld, Johnson, Kanfer, Kanfer, Klinman, Kuhn, Liu, Magidson, Magidson, Maiato, McEwen, McEwen, McKinley, Meraldi, Monda, Moughamian, Musacchio, Musacchio, Musinipally, Olenick, Olziersky, Pandey, Pereira, Peterka, Philip Auckland, Raaijmakers, Ran, Rattner, Rodriguez-Rodriguez, Roscioli, Sacristan, Samejima, Schmidt, Shao, Shrestha, Siller, Simões, Stehman, Tai, Thrower, Toropova, Vagnoni, Vergnolle, Volkov, Wojcik, Wynne, Wynne, Wynne, Yang, Yi, Zhu   +80 more
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Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source