Results 31 to 40 of about 98,180 (299)
Kinetochore-microtubule error correction is driven by differentially regulated interaction modes [PDF]
, 2015 For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B ...
Zhang, T +13 more
core +1 more source
Tumor Biology, 2017 Spindle and kinetochore–associated protein 1 is a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.
Kai Wang +5 more
doaj +1 more source
Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore [PDF]
Open Biology, 2012 The formation of kinetochores shortly before each cell division is a prerequisite for proper chromosome segregation. The synchronous mitoses of Drosophila syncytial embryos have provided an ideal in vivo system to follow kinetochore assembly kinetics and
Zsolt Venkei +7 more
doaj +1 more source
Integrating Functions at the Kinetochore [PDF]
Cell, 2002 Kinetochore components have catalytic as well as structural activities. New evidence illustrates how these proteins integrate spindle morphogenesis with regulation of the timing and accuracy of chromosome segregation.
Shimoda, Soni L., Solomon, Frank
openaire +2 more sources
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Vázquez-Novelle, María Dolores +6 more
core +1 more source
Kinetochore-localized PP1 prematurely silences the spindle checkpoint in meiosis.
, 2023 A) Representative time-lapse images of a SPC105WT cell completing both meiotic divisions. Time 0 indicates SPB separation. Scale bar = 5 μm. B) Graph showing the duration of metaphase I and metaphase II in SPC105WT cells with and without the anchor away ...
Soni Lacefield (573500) +2 more
core +1 more source
eLife, 2023 At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach to chromosomes and focus into spindle poles.
Manuela Richter +5 more
doaj +1 more source
Tension Management in the Kinetochore [PDF]
Current Biology, 2010 The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to
Bloom, Kerry, Yeh, Elaine
openaire +2 more sources
The life and miracles of kinetochores [PDF]
The EMBO Journal, 2009 Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be grouped under four modules. The first module, in the inner kinetochore, contributes a sturdy interface with centromeric chromatin. The second module, the outer kinetochore, contributes a microtubule-binding interface.
Santaguida, Stefano, Musacchio, Andrea
openaire +3 more sources
Adventures of the undead at kinetochores [PDF]
Molecular & Cellular Oncology, 2021 At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by Benzimidazoles 1) mitotic checkpoint serine/threonine kinase B (BUB1B, BUBR1) maintains kinase-phosphatase balance
openaire +3 more sources