Results 31 to 40 of about 98,344 (203)

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly [PDF]

, 2009
In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities
Winter, Jennifer R., Toso, Alberto, Ainslie J. Garrod, Garrod, Ainslie J., Alberto Toso, Jennifer R. Winter, Ana C. Amaro, Patrick Meraldi, Amaro, Ana C., McAinsh, Andrew D., Meraldi, Patrick, Andrew D. McAinsh, Winter JR, Amaro AC, Meraldi P, Toso A, McAinsh AD, Garrod AJ   +17 more
core   +1 more source

Localization and Function of Budding Yeast CENP-A Depends upon Kinetochore Protein Interactions and Is Independent of Canonical Centromere Sequence

Cell Reports, 2014
In many eukaryotes, the centromere is epigenetically specified and not strictly defined by sequence. In contrast, budding yeast has a specific 125 bp sequence required for kinetochore function.
Kung-Hsien Ho, Dai Tsuchiya, Audrey C. Oliger, Soni Lacefield   +3 more
doaj   +1 more source

The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somatic cells [PDF]

Chromosoma, 2006
Drosophila melanogaster is a widely used model organism for the molecular dissection of mitosis in animals. However, despite the popularity of this system, no studies have been published on the ultrastructure of Drosophila kinetochores and kinetochore fibers (K-fibers) in somatic cells.
Maiato, H, Hergert, PJ, Moutinho-Pereira, S, Dong, Y, VandenBeldt, KJ, Rieder, CL, McEwen, BF   +6 more
openaire   +3 more sources

Checkpoint proteins come under scrutiny [PDF]

, 2013
Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Jonathan BA Millar, Mora-Santos, Maria, Millar, Jonathan B. A., Maria Mora-Santos   +3 more
core   +1 more source

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly [PDF]

, 2009
Mitotic spindle formation and chromosome segregation depend critically on kinetochore-microtubule (KT-MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C.
Erich A. Nigg, Chan, Ying Wai, Ying, Wai Chan, Andreas Uldschmid, Uldschmid, Andreas, Schmitz, Michael H.A., Schmitz, Michael H. A., Fava, Luca L., Gerlich, Daniel W., Michael H.A. Schmitz, Ying Wai Chan, Luca L. Fava, Anna Santamaria, Nigg, Erich A., Santamaria, Anna, Daniel W. Gerlich   +15 more
core   +1 more source

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes [PDF]

, 2015
For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B ...
Kalantzaki, Maria, Tanaka, Tomoyuki U.; id_orcid, Kitamura, Etsushi, Zhang, Tongli, Mino, Akihisa, Novák , Béla   +5 more
core   +1 more source

The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells [PDF]

Open Biology, 2015
The spindle assembly checkpoint is a surveillance mechanism that blocks anaphase onset until all chromosomes are properly attached to microtubules of the mitotic spindle.
Gina V. Caldas, Tina R. Lynch, Ryan Anderson, Sana Afreen, Dileep Varma, Jennifer G. DeLuca   +5 more
doaj   +1 more source

Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.

PLoS Genetics, 2016
The accurate segregation of chromosomes during cell division is achieved by attachment of chromosomes to the mitotic spindle via the kinetochore, a large multi-protein complex that assembles on centromeres.
Eva Herrero, Peter H Thorpe
doaj   +1 more source

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.

PLoS Genetics, 2020
The kinetochore, a multi-protein complex assembled on centromeres, is essential to segregate chromosomes during cell division. Deficiencies in kinetochore function can lead to chromosomal instability and aneuploidy-a hallmark of cancer cells. Kinetochore
Guðjón Ólafsson, Peter H Thorpe
doaj   +1 more source

Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I [PDF]

, 2013
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
Sourav Sarkar, Prakash Arumugam, Arumugam P., Louise Newnham, Rajesh T Shenoy, Eva Hoffmann (159398), Sourav Sarkar (430861), Newnham, Louise, Millar J.B.A., Louise Newnham (430862), Shenoy, Rajesh T., Dalgaard J.Z., Prakash Arumugam (303310), Eva Hoffmann, Millar, Jonathan B.A., Newnham L., Sarkar, Sourav, Sarkar S., Millar, Jonathan B. A., Jacob Z. Dalgaard (303312), Arumugam, Prakash, Jonathan B. A. Millar (430863), Hoffmann, Eva, Jonathan B A Millar, Hoffmann E., Dalgaard, Jacob Z., Jacob Z Dalgaard, Rajesh T. Shenoy (223422), Shenoy R.T.   +28 more
core   +1 more source