Results 51 to 60 of about 98,180 (299)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Identification of four unconventional kinetoplastid kinetochore proteins KKT22–25 in Trypanosoma brucei [PDF]

Open Biology, 2019
The kinetochore is a multi-protein complex that drives chromosome segregation in eukaryotes. It assembles onto centromere DNA and interacts with spindle microtubules during mitosis and meiosis. Although most eukaryotes have canonical kinetochore proteins,
Olga O. Nerusheva, Patryk Ludzia, Bungo Akiyoshi   +2 more
doaj   +1 more source

Reductionism at the vertebrate kinetochore [PDF]

Journal of Cell Biology, 2012
The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol.
Stankovic, Ana, Jansen, Lars E.T.
openaire   +4 more sources

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases [PDF]

, 2010
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which they exhibit oscillatory movement. These movements are accompanied by changes in the distance between sister kinetochores,
Porter, Iain M.; id_orcid, McClelland, Sarah E., King, E. M., Toso, Alberto, Swedlow, Jason, Swedlow, Jason R.; id_orcid, McClelland, S. E., Meraldi, P., Gaudenz Danuser, McAinsh, Andrew D., Posch, Markus, Emma M. King, Dorn, J. F., King, Emma M., Andrew D. McAinsh, Winter, J. R., Iain M. Porter, Khuloud Jaqaman, Ana C. Amaro, Mchedlishvili, N., Dorn, Jonas F., Toso, A., Porter, I. M., Posch, M., Winter, Jennifer R., Jonas F. Dorn, Jason R. Swedlow, Jaqaman, Khuloud, Jennifer R. Winter, Sarah E. McClelland, Jaqaman, K., Amaro, Ana C., Danuser, Gaudenz, Porter, Iain M., Danuser, G., Markus Posch, Elliott, Hunter L., Swedlow, Jason R., Amaro, A. C., Nunu Mchedlishvili, Alberto Toso, Hunter L. Elliott, Patrick Meraldi, Mchedlishvili, Nunu, Meraldi, Patrick   +44 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation.

PLoS Genetics, 2019
The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. Here,
Raymond T Suhandynata, Yun Quan, Yusheng Yang, Wei-Tsung Yuan, Claudio P Albuquerque, Huilin Zhou   +5 more
doaj   +1 more source

Human kinetochores are swivel joints that mediate microtubule attachments

eLife, 2016
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs   +2 more
doaj   +1 more source

Cug2 is essential for normal mitotic control and CNS development in zebrafish. [PDF]

, 2011
Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells.
H T Kim, J H So, Dae-Gwon Ahn, W Koh, Kim, SH, S H Kim, C H Kim, Kim, HT, Kim, NS, Lee, S, Seung-Hyun Jung, S H Jung, Jung, SH, D G Ahn, Nam-Soon Kim, Ahn, DG, Cheol-Hee Kim, Wansoo Koh, Soojin Lee, Koh, W, Ju-Hoon So, So, JH, Kim, CH, Hyun-Taek Kim, Soo-Hyun Kim, S Lee   +25 more
core   +1 more source

Kinetochore-microtubule attachments in Stochastic Reaction-Diffusion-Dynamics Model.

, 2022
A) A regular kinetochore (KT) representation. Blue bead represents the main body of the KT and orange wall section is the outer KT, which is covered by grid of Ndc80 seeds. B) Schematic of the KT model.
Artem Zhmurov (472712), Valeri Barsegov (472713), Alex Mogilner (34091), Evgenii Kliuchnikov (12770739), Kenneth A. Marx (108466)   +4 more
core   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source