Results 61 to 70 of about 98,344 (203)

Molecular basis of outer kinetochore assembly on CENP-T

eLife, 2016
Stable kinetochore-microtubule attachment is essential for cell division. It requires recruitment of outer kinetochore microtubule binders by centromere proteins C and T (CENP-C and CENP-T).
Pim J Huis in 't Veld, Sadasivam Jeganathan, Arsen Petrovic, Priyanka Singh, Juliane John, Veronica Krenn, Florian Weissmann, Tanja Bange, Andrea Musacchio   +8 more
doaj   +1 more source

Exploring Plant Meiosis: Insights from the Kinetochore Perspective

Current Issues in Molecular Biology, 2023
The central player for chromosome segregation in both mitosis and meiosis is the macromolecular kinetochore structure, which is assembled by >100 structural and regulatory proteins on centromere DNA.
Kang-Di Zhou, Cai-Xia Zhang, Fu-Rong Niu, Hao-Chen Bai, Dan-Dan Wu, Jia-Cheng Deng, Hong-Yuan Qian, Yun-Lei Jiang, Wei Ma   +8 more
doaj   +1 more source

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules [PDF]

, 2017
The initial kinetochore encounter with a spindle microtubule (kinetochore capture) is one of the rate-limiting steps in establishing proper kinetochore–microtubule interaction during mitosis. Kinetochore capture is facilitated by multiple factors such as
Nicola O’Reilly, Vasileva, Vanya, Tanaka, Tomoyuki U.; id_orcid, Vanya Vasileva, Gierlinski, Marek, Marek Gierlinski, Etsushi Kitamura, Tomoyuki U. Tanaka, Yue, Zuojun, Kitamura, Etsushi, Zuojun Yue, O'Reilly, Nicola   +11 more
core   +1 more source

Human kinetochores are swivel joints that mediate microtubule attachments

eLife, 2016
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs   +2 more
doaj   +1 more source

Reductionism at the vertebrate kinetochore [PDF]

Journal of Cell Biology, 2012
The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol.
Stankovic, Ana, Jansen, Lars E.T.
openaire   +4 more sources

CoilEdinburgh/KinetochoreDistances: Kinetochore Distances

, 2023
ImageJ1 plugin to semi automate kinetochore distance ...
CoilEdinburgh
core   +1 more source

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation.

PLoS Genetics, 2019
The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. Here,
Raymond T Suhandynata, Yun Quan, Yusheng Yang, Wei-Tsung Yuan, Claudio P Albuquerque, Huilin Zhou   +5 more
doaj   +1 more source

The dynamic kinetochore-microtubule interface [PDF]

, 2004
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably fluid, with the microtubules growing and shrinking at their point of attachment to ...
Salmon, ED, DeLuca, J, Maiato, H, Earnshaw, WC   +3 more
core   +2 more sources

Quantitative Analysis of Kinetochore Protein Levels and Inter-Kinetochore Distances in Mammalian Cells During Mitosis

Bio-Protocol
The mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis.
Neeraj Wasnik, Mahima Singhal, Sukirti Khantwal, Sanghamitra Mylavarapu, Sivaram Mylavarapu   +4 more
doaj   +1 more source

Kinetochore structure: electron spectroscopic imaging of the kinetochore. [PDF]

The Journal of cell biology, 1989
The structure of the kinetochore in thin section has been studied in the Indian muntjac by an electron spectroscopic imaging technique. This procedures allows the analysis of the distribution of phosphorus within the layers of the kinetochore. The results indicate that this element is a major component of both the inner and outer plates whereas it is ...
J B, Rattner, D P, Bazett-Jones
openaire   +2 more sources