Results 81 to 90 of about 94,326 (306)

Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

eLife, 2020
The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh, Alexandra F Long, Sophie Dumont   +2 more
doaj   +1 more source

Kinetochore-associated Stu2 promotes chromosome biorientation in vivo

, 2019
Accurate segregation of chromosomes to daughter cells is a critical aspect of cell division. It requires the kinetochores on duplicated chromosomes to biorient, attaching to microtubules from opposite poles of the cell.
Rena K. Evans (7465595), Michael J. MacCoss (125430), Luke M. Rice (7465601), Elisabeth A. Geyer (7465598), Matthew P. Miller (2328283), Alex Zelter (1609087), Sue Biggins (280260), Charles L. Asbury (7465604), Trisha N. Davis (5813)   +8 more
core   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.

PLoS Genetics, 2015
In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are essential for both spindle formation and chromosome segregation, but the nature and function of ...
Sarah J Radford, Tranchau L Hoang, A Agata Głuszek, Hiroyuki Ohkura, Kim S McKim   +4 more
doaj   +1 more source

Kinetochore-binding deficient Stu2 exhibits a biorientation defect and spindle checkpoint-dependent cell cycle delay.

, 2019
A) Exponentially growing stu2-AID cdc20-AID cultures with an ectopically expressed STU2 allele (STU2WT, SBY17369; stu2ccΔ, SBY17371) or without an ectopic allele (no covering allele, SBY17367) that also contained MTW1-3GFP (kinetochore) and SPC42-CFP ...
Rena K. Evans (7465595), Michael J. MacCoss (125430), Luke M. Rice (7465601), Elisabeth A. Geyer (7465598), Matthew P. Miller (2328283), Alex Zelter (1609087), Sue Biggins (280260), Charles L. Asbury (7465604), Trisha N. Davis (5813)   +8 more
core   +1 more source

Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster [PDF]

, 2016
Accurate chromosome segregation during mitosis and meiosis is crucial for cellular and organismal viability. Kinetochores connect chromosomes with spindle microtubules and are essential for chromosome segregation.
Stefan Raunser, Petrovic, A., Liu, Yahui, Franz Herzog, Andrea Musacchio, Musacchio, A., Arsen Petrovic, Keller, Jenny, Keller, J., Mosalaganti, S., Liu, Y., Rombaut, P., Shyamal Mosalaganti, Yahui Liu, Petrovic, Arsen, Rombaut, Pascaline, Musacchio, Andrea, Jenny Keller, Herzog, F., Mosalaganti, Shyamal, Raunser, S., Herzog, Franz, Raunser, Stefan, Pascaline Rombaut   +23 more
core   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

A Nucleoporin at the Meiotic Kinetochore [PDF]

Developmental Cell, 2016
In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
openaire   +2 more sources

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Erich A. Nigg, Kleylein-Sohn, J, Nigg, EA, Thein, Kerstin H., Kerstin H. Thein, Gruneberg, Ulrike, Nigg, E. A., Grueneberg, U., Julia Kleylein-Sohn, Thein, KH, Kleylein-Sohn, Julia, Kleylein-Sohn, J., Ulrike Gruneberg, Nigg, Erich A., Thein, K. H.   +14 more
core   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source