Results 81 to 90 of about 98,344 (203)
Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore [PDF]
, 2016 Accurate chromosome segregation depends on proper kinetochore–microtubule attachment. Upon microtubule interaction, kinetochores are subjected to forces generated by the microtubules. In this work, we used laser ablation to sever microtubules attached to
Iva M. Tolić +34 more
core +1 more source
mSphere, 2018 Kinetochore clustering, frequently observed in yeasts, plays a key role in genome organization and chromosome segregation. In the absence of the metaphase plate arrangement, kinetochore clustering in yeast species is believed to facilitate timely ...
Vikas Yadav, Kaustuv Sanyal
doaj +1 more source
PLoS Genetics, 2015 In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are essential for both spindle formation and chromosome segregation, but the nature and function of ...
Sarah J Radford +4 more
doaj +1 more source
eLife, 2020 The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh +2 more
doaj +1 more source
A Nucleoporin at the Meiotic Kinetochore [PDF]
Developmental Cell, 2016 In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
openaire +2 more sources
In Vitro Kinetochore Assembly [PDF]
, 2016 The kinetochore is the primary site of interaction between chromosomes and microtubules of the mitotic spindle during chromosome segregation. Kinetochores are composed of more than 100 proteins that transiently assemble during mitosis at a single epigenetically defined region on each chromosome, known as the centromere.
Matthew D D, Miell, Aaron F, Straight
openaire +2 more sources
AI-Assisted Forward Modeling of Biological Structures
Frontiers in Cell and Developmental Biology, 2019 The rise of machine learning and deep learning technologies have allowed researchers to automate image classification. We describe a method that incorporates automated image classification and principal component analysis to evaluate computational models
Josh Lawrimore +3 more
doaj +1 more source
Cug2 is essential for normal mitotic control and CNS development in zebrafish. [PDF]
, 2011 Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells.
H T Kim +25 more
core +1 more source
Kinetochore-microtubule attachments in Stochastic Reaction-Diffusion-Dynamics Model.
, 2022 A) A regular kinetochore (KT) representation. Blue bead represents the main body of the KT and orange wall section is the outer KT, which is covered by grid of Ndc80 seeds. B) Schematic of the KT model.
Artem Zhmurov (472712) +4 more
core +1 more source
BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore
eLife, 2018 Accurate chromosome segregation relies on bioriented amphitelic attachments of chromosomes to microtubules of the mitotic spindle, in which sister chromatids are connected to opposite spindle poles.
Frances Edwards +4 more
doaj +1 more source