Results 91 to 100 of about 98,344 (203)
Phosphorylation of the kinetochore is temporally regulated.
, 2019 Schematic of predicted kinetochore proteins complexes [38], with CCR phosphorylation sites and proteins rendered as a heat map of fold change scaled to the unit integer.
Michael D. Urbaniak (166658) +1 more
core +1 more source
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80
eLife, 2017 Chromosome segregation requires robust interactions between the macromolecular kinetochore structure and dynamic microtubule polymers. A key outstanding question is how kinetochore-microtubule attachments are modulated to ensure that bi-oriented ...
David M Kern +4 more
doaj +1 more source
C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast [PDF]
, 2020 Kinetochores are macromolecular protein assemblies at centromeres that mediate accurate chromosome segregation during cell division. The outer kinetochore KNL1SPC105, MIS12MTW1, and NDC80NDC80 complexes assemble the KMN network, which harbors the sites ...
Witte, Gregor +10 more
core +1 more source
The Ndc80 complex bridges two Dam1 complex rings
eLife, 2017 Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore.
Jae ook Kim +8 more
doaj +1 more source
Studying Kinetochore Kinases [PDF]
, 2016 Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Saurin, Adrian T., Kops, Geert J. P. L.
openaire +4 more sources
Stochastic modelling of chromosomal segregation : errors can introduce correction [PDF]
, 2014 Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander +6 more
core +1 more source
Cell Reports, 2015 Chromosome bi-orientation occurs after conversion of initial lateral attachments between kinetochores and spindle microtubules into stable end-on attachments near the cell equator. After bi-orientation, chromosomes experience tension from spindle forces,
Danica Drpic +4 more
doaj +1 more source
Chromosome instability and kinetochore dysfunction [PDF]
, 2007 Chromosomal instability (CIN) has been recognized as a hallmark of human cancer and is caused by continuous chromosome missegregation during mitosis.
Tomonaga, T., Nomura, F.
core
Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster.
PLoS ONE, 2007 BackgroundKinetochores are large multiprotein complexes indispensable for proper chromosome segregation. Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochores ...
Marcin R Przewloka +8 more
doaj +1 more source
Mosaic origin of the eukaryotic kinetochore [PDF]
, 2019 The emergence of eukaryotes from ancient prokaryotic lineages embodied a remarkable increase in cellular complexity. While prokaryotes operate simple systems to connect DNA to the segregation machinery during cell division, eukaryotes use a highly ...
Snel, Berend +8 more
core