Results 111 to 120 of about 94,326 (306)
International Journal of Cancer, EarlyView.Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn +13 more
wiley +1 more source
The Ndc80 complex bridges two Dam1 complex rings
eLife, 2017 Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore.
Jae ook Kim +8 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Parabens (PBs) are compounds widely used as preservatives in personal care products, food, and pharmaceuticals. Methylparaben (MePB) is the most used by different industries due to its chemical properties and low cost. The high daily human exposure to these compounds has raised concerns about their potential effects on health, particularly on ...
Yenny Ramírez‐Jara +11 more
wiley +1 more source
Cell Reports, 2015 Chromosome bi-orientation occurs after conversion of initial lateral attachments between kinetochores and spindle microtubules into stable end-on attachments near the cell equator. After bi-orientation, chromosomes experience tension from spindle forces,
Danica Drpic +4 more
doaj +1 more source
Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver +11 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori +5 more
wiley +1 more source
Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase
Cell Reports, 2016 Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros +4 more
doaj +1 more source
Initial Characterization of two novel spindle proteins, CHICA and HURP [PDF]
, 2008 During mitotic spindle assembly, the sister chromatids have to be captured by kinetochore (K) -fibers (bundles of kinetochore microtubules; KMTs) to ensure stable attachment of the chromosomes.
Nagel, Susanna
core
Nephrogenic Systemic Fibrosis: A Rare Contemporary Case After a Decade of Declining Incidence
JEADV Clinical Practice, EarlyView.ABSTRACT Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder associated with exposure to gadolinium‐based contrast agents in patients with renal impairment. Although its incidence has markedly declined since the restriction of high‐risk linear gadolinium agents, sporadic cases may still occur.
Marta Sánchez Díaz +5 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2018 Various experiments have indicated that anaphase chromosomes continue to move after their kinetochore microtubules are severed. The chromosomes move poleward at an accelerated rate after the microtubules are cut but they slow down 1–3 min later and move ...
Arthur Forer +3 more
doaj +1 more source