Results 111 to 120 of about 98,344 (203)

On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa

mBio
Transmission of genetic material from one generation to the next is a fundamental feature of all living cells. In eukaryotes, a macromolecular complex called the kinetochore plays crucial roles during chromosome segregation by linking chromosomes to ...
Corinna Benz, Maximilian W. D. Raas, Pragya Tripathi, Drahomíra Faktorová, Eelco C. Tromer, Bungo Akiyoshi, Julius Lukeš   +6 more
doaj   +1 more source

Kinetochores [PDF]

Current Biology, 2000
openaire   +2 more sources

Kinetochore Structure: Pulling Answers from Yeast

, 2012
Despite the identification of multiple kinetochore proteins, their structure and organization has remained unclear. New work uses electron microscopy to visualize isolated budding yeast kinetochore particles and reveal the kinetochore structure on ...
Kern, David Matthew, Cheeseman, Iain M
core   +1 more source

hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain

, 2011
Accurate chromosome segregation in mitosis is required to maintain genetic stability. hZwint-1 [human Zw10 (Zeste white 10)-interacting protein 1] is a kinetochore protein known to interact with the kinetochore checkpoint protein hZw10. hZw10, along with
Jakub K. Famulski, Gordon K. T. Chan, Larissa J. Vos   +2 more
core   +1 more source

GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics

, 2017
Error-free chromosome segregation requires dynamic control of microtubule attachment to kinetochores, but how kinetochore-microtubule interactions are spatially and temporally controlled during mitosis remains incompletely understood.
Jeffrey van Haren, Torsten Wittmann, Hayley Pemble, Praveen Kumar   +3 more
core   +1 more source

Keeping kinetochores on track

European Journal of Cell Biology, 2012
The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in ...
openaire   +5 more sources

Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis

, 2011
How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae.
Tanaka, Tomoyuki U.; id_orcid, Tanaka, Kozo, Clayton, Lesley, Kitamura, Etsushi, Gandhi, Sapan R., Mino, Akihisa, Sapan R. Gandhi, Tomoyuki U. Tanaka, Marek Gierliński, Gierlinski, Marek, Etsushi Kitamura, Akihisa Mino, Kozo Tanaka, Lesley Clayton   +13 more
core   +1 more source

Meiosis-specific distal cohesion site decoupled from the kinetochore

Nature Communications
Primary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find
Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi Akera   +3 more
doaj   +1 more source

Cell cycle dependent methylation of Dam1 contributes to kinetochore integrity and faithful chromosome segregation.

PLoS Genetics
The kinetochore, a megadalton structure composed of centromeric (CEN) DNA and protein complexes, is required for faithful chromosome segregation in eukaryotes.
Prashant K Mishra, Wei-Chun Au, John S Choy, Pedro G Castineira, Afsa Khawar, Chloé Tessier, Sudipto Das, Andresson Thorkell, Peter H Thorpe, Elaine Yeh, Kerry S Bloom, Munira A Basrai   +11 more
doaj   +1 more source

CCAN forms the spherical shell-like structure in interphase kinetochores. [PDF]

Sci Adv
Sakai Y, Ariyoshi M, Hirano Y, Mahana Y, Suzuki A, Hirota T, Tachikawa M, Fukagawa T.   +7 more
europepmc   +1 more source