Results 101 to 110 of about 94,326 (306)

Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80

eLife, 2017
Chromosome segregation requires robust interactions between the macromolecular kinetochore structure and dynamic microtubule polymers. A key outstanding question is how kinetochore-microtubule attachments are modulated to ensure that bi-oriented ...
David M Kern, Julie K Monda, Kuan-Chung Su, Elizabeth M Wilson-Kubalek, Iain M Cheeseman   +4 more
doaj   +1 more source

Stochastic modelling of chromosomal segregation : errors can introduce correction

, 2014
Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander, Matzavinos, Anastasios, Voller, Zachary, Liu, Sijia, Shtylla, Blerta, Chaplain, Mark A.J.   +5 more
core   +1 more source

The dynamic kinetochore-microtubule interface [PDF]

, 2004
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably fluid, with the microtubules growing and shrinking at their point of attachment to ...
Salmon, ED, Maiato, Helder, DeLuca, Jennifer, Earnshaw, William C., Salmon, E. D., DeLuca, J, Salmon, E D, Earnshaw, William C, Maiato, H, Earnshaw, WC   +9 more
core   +1 more source

Towards understanding of unconventional kinetochores in kinetoplastids

, 2021
The kinetochore is the macromolecular protein machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids, an evolutionarily divergent group of eukaryotes, possess a unique set of kinetochore proteins (KKT1—20 ...
Ludzia, Patryk
core   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen—A Case Report and Literature Review

Diagnostic Cytopathology, EarlyView.
ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
William H. Wu, Joanna K. M. Ng, Joshua J. X. Li   +2 more
wiley   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Studying Kinetochore Kinases [PDF]

, 2016
Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Saurin, Adrian T., Kops, Geert J. P. L.
openaire   +4 more sources

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster.

PLoS ONE, 2007
BackgroundKinetochores are large multiprotein complexes indispensable for proper chromosome segregation. Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochores ...
Marcin R Przewloka, Wei Zhang, Patricia Costa, Vincent Archambault, Pier Paolo D'Avino, Kathryn S Lilley, Ernest D Laue, Andrew D McAinsh, David M Glover   +8 more
doaj   +1 more source