Results 101 to 110 of about 98,344 (203)
Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase
Cell Reports, 2016 Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros +4 more
doaj +1 more source
A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds [PDF]
, 2010 Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in ...
Stefano Santaguida +23 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2018 Various experiments have indicated that anaphase chromosomes continue to move after their kinetochore microtubules are severed. The chromosomes move poleward at an accelerated rate after the microtubules are cut but they slow down 1–3 min later and move ...
Arthur Forer +3 more
doaj +1 more source
The Saccharomyces cerevisiae kinetochore
FEBS Letters, 1996 Accurate chromosome segregation is DApenDAnt on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA.
Lechner, Johannes, Ortiz, Jennifer
openaire +2 more sources
Chromosome congression by CENP-E and CENP-Q dependent pathways [PDF]
The timely and efficient movement of chromosomes to the spindle equator during mitosis is a prerequisite for accurate chromosome segregation.
Bancroft, James M.
core
Probing the Architecture of the Budding Yeast Inner Kinetochore [PDF]
, 2018 Chromosome segregation must occur with fidelity to maintain genome stability and prevent aneuploid disorders. During segregation, the kinetochore is assembled onto centromeric DNA and achieves the attachment of microtubule plus ends, which provide the ...
Drysdale, Claire
core +1 more source
The budding yeast kinetochore: less simple than expected
, 2000 We focus on the established kinetochore proteins of the budding yeast, Saccharomyces cerevisiae. The location and functional evidence for each kinetochore protein is summarized along with the data that supports protein-protein and genetic interactions ...
Lechner, J., Ortiz, J.
core +1 more source
PLoS Computational Biology, 2015 Kinetochores are multi-protein complexes that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called kinetochore (K)-fibres) from respective poles. These kinetochore-attached K-fibres generate pushing and pulling forces,
Jonathan W Armond +3 more
doaj +1 more source
The kinetochore protein KNL1 links kinetochore-microtubule attachment and checkpoint signaling during mitosis [PDF]
, 2014 2014 Summer.Mitosis is the phase of the cell cycle in which replicated chromosomes physically separate, resulting in the formation of two genetically identical daughter cells.
Prenni, Jessica, committee member +5 more
core
Centromere/kinetochore is assembled through CENP-C oligomerization [PDF]
Hara M., Ariyoshi M., Sano T., et al. Centromere/kinetochore is assembled through CENP-C oligomerization. Molecular Cell 83, 2188 (2023); https://doi.org/10.1016/j.molcel.2023.05.023.Kinetochore is an essential protein complex required for accurate ...
Nozawa, Ryu-Suke +8 more
core +1 more source