Results 131 to 140 of about 94,326 (306)
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis
Scientific Reports, 2017 For faithful chromosome segregation, the formation of stable kinetochore–microtubule attachment and its monitoring by the spindle assembly checkpoint (SAC) are coordinately regulated by mechanisms that are currently ill-defined.
Masanori Ikeda, Kozo Tanaka
doaj +1 more source
Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping +4 more
core +1 more source
Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy
Andrology, EarlyView.ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby +10 more
wiley +1 more source
On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa
mBioTransmission of genetic material from one generation to the next is a fundamental feature of all living cells. In eukaryotes, a macromolecular complex called the kinetochore plays crucial roles during chromosome segregation by linking chromosomes to ...
Corinna Benz +6 more
doaj +1 more source
Manipulating kinetochore function with synthetic physical interactions [PDF]
, 2018 The kinetochore is a large protein complex that assembles on centromeres. It enables accurate chromosome segregation by attaching chromosomes to the mitotic spindle via microtubules and by recruiting regulators that control mitosis.
Olafsson, Gudjon
core
Andrology, EarlyView.ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz +12 more
wiley +1 more source
European Journal of Cell Biology, 2012 The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in ...
openaire +5 more sources
Chromosome instability and kinetochore dysfunction [PDF]
, 2007 Chromosomal instability (CIN) has been recognized as a hallmark of human cancer and is caused by continuous chromosome missegregation during mitosis.
Tomonaga, T., Nomura, F.
core