Cell cycle proteins as promising targets in cancer therapy. [PDF]
Nat Rev Cancer, 2017 Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy.
Otto T, Sicinski P.
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Targeting cell cycle proteins in breast cancer cells with siRNA by using lipid-substituted polyethylenimines [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 The cell cycle proteins are key regulators of cell cycle progression whose de-regulation is one of the causes of breast cancer. RNA interference (RNAi) is an endogenous mechanism to regulate gene expression and it could serve as the basis of regulating ...
Manoj eParmar +6 more
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Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease. [PDF]
Acta Neuropathol, 2015 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder for which no effective treatment is available. Increased insight into the disease mechanism in early stages of pathology is required for the development of a successful therapy ...
van Leeuwen LA, Hoozemans JJ.
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Copper Chaperone Atox1 Interacts with Cell Cycle Proteins [PDF]
Computational and Structural Biotechnology Journal, 2018 The anaphase-promoting complex (APC) is involved in several processes in the cell cycle, most prominently it facilitates the separation of the sister chromatids during mitosis, before cell division.
Maria Matson Dzebo +5 more
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Cell cycle proteins: Linking the cell cycle to tumors. [PDF]
Oncol ResThe cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them.
Zhong J +11 more
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Inhibition of prostate cancer growth by solanine requires the suppression of cell cycle proteins and the activation of ROS/P38 signaling pathway. [PDF]
Cancer Med, 2016 Solanine, a naturally steroidal glycoalkaloid in nightshade (Solanum nigrum Linn.), can inhibit proliferation and induce apoptosis of tumor cells. However, the mechanism of solanine‐suppressing prostate cancer cell growth remains to be elucidated.
Pan B +7 more
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Cell cycle proteins moonlight in multiciliogenesis. [PDF]
Science, 2017 Proteins that control cell cycle progression also drive multiciliated cell ...
Levine M, Holland A.
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Tumor suppressors and cell-cycle proteins in lung cancer. [PDF]
Patholog Res Int, 2011 The cell cycle is the cascade of events that allows a growing cell to duplicate all its components and split into two daughter cells. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin ...
Baldi A +5 more
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BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation. [PDF]
Oncogene, 2013 The BRCA1 tumor suppressor protein heterodimerizes with its partner protein, BARD1, via the RING domain present in both proteins. The heterodimer contains an E3 ubiquitin ligase activity and participates in multiple cellular functions such as cell cycle ...
Shabbeer S +9 more
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A map of protein dynamics during cell-cycle progression and cell-cycle exit.
PLoS Biology, 2017 The cell-cycle field has identified the core regulators that drive the cell cycle, but we do not have a clear map of the dynamics of these regulators during cell-cycle progression versus cell-cycle exit.
Sara Gookin +7 more
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