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Cell cycle proteins: Linking the cell cycle to tumors. [PDF]
Oncol ResThe cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them.
Zhong J +11 more
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Cell cycle proteins moonlight in multiciliogenesis. [PDF]
Science, 2017 Proteins that control cell cycle progression also drive multiciliated cell ...
Levine M, Holland A.
europepmc +4 more sources
Cell cycle proteins as promising targets in cancer therapy [PDF]
Nature Reviews Cancer, 2017 Tobias Otto +2 more
exaly +2 more sources
Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer’s disease [PDF]
Acta Neuropathologica, 2015 Jeroen J M Hoozemans +1 more
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Cell Cycle and Related Protein [PDF]
Disease Markers, 2007 John Farleya, Laurent Ozbunb, Goli Samimic and Michael J. Birrerb,∗ Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814, USA Cell and Cancer Biology Department, Medicine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA Cancer ...
Farley, John +3 more
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Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21
Biology, 2023 The progression through the cell cycle phases is driven by cyclin-dependent kinases and cyclins as their regulatory subunits. As nuclear protein, the cell cycle inhibitor p21/CDKN1A arrests the cell cycle at the growth phase G1 by inhibiting the activity of cyclin-dependent kinases.
Levin Lataster +5 more
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Switching the Cell Cycle. Kip-Related Proteins in Plant Cell Cycle Control [PDF]
Plant Physiology, 2005 During the development of multicellular organisms, many different cell types are created. These display characteristic cell cycle programs that can radically change during the organism's lifetime ([Jakoby and Schnittger, 2004][1]; [Fig. 1][2]).
Verkest, Aurine +4 more
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Proteins Made in the Mammalian Cell Cycle
Journal of Biological Chemistry, 1971 DNA-binding proteins made by Chinese hamster ovary (CHO) cells at specific times in their cell cycle were chromatographed on DNA-cellulose and analyzed with sodium dodecyl sulfate polyacrylamide electrophoresis. Some small proteins (less than 25,000 mol wt) were made in S (the period of DNA synthesis), but not during G1 (the period following mitosis ...
T O, Fox, A B, Pardee
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Pocket proteins and cell cycle control [PDF]
Oncogene, 2005 The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes.
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Alterations in cell cycle profile and cell cycle protein expression in neuroblastoma cells stably transfected with tau protein [PDF]
BMC Neuroscience, 2007 Alzheimer's disease is characterized by extracellular deposition of beta amyloid peptide and intracellular deposition of hyperphosphorylated tau protein in isocortical brain areas. Recently, we and others have shown that vulnerable neurons or tau aggregate-bearing neurons aberrantly express cell cycle proteins namely cdk inhibitors. In order to analyse
Otto Tobias +5 more
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