Results 1 to 10 of about 33,029 (115)

Viral Cyclins Mediate Separate Phases of Infection by Integrating Functions of Distinct Mammalian Cyclins [PDF]

open access: yesPLoS Pathogens, 2012
Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Linda van Dyk   +2 more
exaly   +2 more sources

The Less Known Cyclins—Uncovered

open access: yesApplied Sciences (Switzerland), 2021
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Adrian Krajewski   +2 more
exaly   +3 more sources

Sumoylation of cyclin and its therapeutic potential for cancer [PDF]

open access: yesAnimal Cells and Systems
The precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
doaj   +2 more sources

Identification of Arabidopsis Meiotic Cyclins Reveals Functional Diversification among Plant Cyclin Genes

open access: yesPLoS Genetics, 2013
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulánková   +2 more
exaly   +3 more sources

In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

open access: yesFrontiers in Veterinary Science, 2022
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah   +6 more
doaj   +1 more source

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

open access: yesBiology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika   +3 more
doaj   +1 more source

Two-way communication between cell cycle and metabolism in budding yeast: what do we know?

open access: yesFrontiers in Microbiology, 2023
Coordination of cell cycle and metabolism exists in all cells. The building of a new cell is a process that requires metabolic commitment to the provision of both Gibbs energy and building blocks for proteins, nucleic acids, and membranes.
Yanfei Zhang   +5 more
doaj   +1 more source

Emerging Mechanisms of G1/S Cell Cycle Control by Human and Mouse Cytomegaloviruses

open access: yesmBio, 2021
Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation.
Boris Bogdanow   +2 more
doaj   +1 more source

Prediction of Cyclin Protein Using Two-Step Feature Selection Technique

open access: yesIEEE Access, 2020
Cyclins are a family of proteins that regulate the cell cycle by activating cyclin-dependent kinases or a group of enzymes required in the cell cycle. Constructing a model to classify Cyclins is of importance to understand their function. It is urgent to
Jia-Nan Sun   +6 more
doaj   +1 more source

AaCycTL Regulates Cuticle and Trichome Development in Arabidopsis and Artemisia annua L.

open access: yesFrontiers in Plant Science, 2021
Artemisinin is an important drug for resistance against malaria. Artemisinin is derived from the glandular trichome of leaves, stems, or buds of the Chinese traditional herb Artemisia annua.
Boran Dong   +15 more
doaj   +1 more source

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