Results 1 to 10 of about 32,826 (263)
Sumoylation of cyclin and its therapeutic potential for cancer [PDF]
Animal Cells and SystemsThe precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
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Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae [PDF]
CellsCell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity.
Gabriele Schreiber +5 more
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The Less Known Cyclins—Uncovered
Applied Sciences, 2021 Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń +4 more
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Frontiers in Veterinary Science, 2022 Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah +6 more
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Biology, 2023 Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika +3 more
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Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. [PDF]
PLoS Pathogens, 2012 Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee +5 more
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Two-way communication between cell cycle and metabolism in budding yeast: what do we know?
Frontiers in Microbiology, 2023 Coordination of cell cycle and metabolism exists in all cells. The building of a new cell is a process that requires metabolic commitment to the provision of both Gibbs energy and building blocks for proteins, nucleic acids, and membranes.
Yanfei Zhang +5 more
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Emerging Mechanisms of G1/S Cell Cycle Control by Human and Mouse Cytomegaloviruses
mBio, 2021 Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation.
Boris Bogdanow +2 more
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Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
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Prediction of Cyclin Protein Using Two-Step Feature Selection Technique
IEEE Access, 2020 Cyclins are a family of proteins that regulate the cell cycle by activating cyclin-dependent kinases or a group of enzymes required in the cell cycle. Constructing a model to classify Cyclins is of importance to understand their function. It is urgent to
Jia-Nan Sun +6 more
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