Results 1 to 10 of about 37,065 (297)
Translational control of cyclins [PDF]
Cell Division, 2011 Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response
Lai Ming-Chih, Tarn Woan-Yuh
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Cell Reports, 2020 Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations.
Weiwei Shan +18 more
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Current Issues in Molecular Biology, 2023 The development of K-Ras independence may explain the failure of targeted therapy for pancreatic cancer (PC). In this paper, active N as well as K-Ras was shown in all human cell lines tested.
Robert Ferguson +8 more
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Cell Reports, 2020 Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif.
Mihkel Örd +10 more
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Dynamic expression profiles from static cytometry data: component fitting and conversion to relative, "same scale" values. [PDF]
PLoS ONE, 2012 Cytometry of asynchronous proliferating cell populations produces data with an extractable time-based feature embedded in the frequency of clustered, correlated events.
Jayant Avva +4 more
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Cellular Oncology, 2006 Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
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Role of Kupffer Cells in Thioacetamide-Induced Cell Cycle Dysfunction
Molecules, 2011 It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell cycle and postnecrotic liver regeneration induced by thioacetamide
Mirandeli Bautista +10 more
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Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. [PDF]
PLoS Genetics, 2016 E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division.
Junko Odajima +12 more
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Cancer Management and Research, 2020 Li-Wei Shi,1,2 Zhi-Bo Zhao,3 Li Zhong,1 Jian Gao,1 Jian-Ping Gong,3 Hang Chen,4 Yu Min,4 Yi-Yin Zhang,5 Zhi Li4 1Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of ...
Shi LW +8 more
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Promoter de-methylation of
Clinical Epigenetics, 2011 Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic ...
Hsu Anna +5 more
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