Results 1 to 10 of about 27,135 (258)

Cyclins and CDKs in the regulation of meiosis-specific events

Frontiers in Cell and Developmental Biology, 2022
How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events.
Cristina Martín-Castellanos
exaly   +4 more sources

Clinical data analysis of CDKs expression and prognosis in breast cancer [PDF]

World Cancer Research Journal, 2023
Objective: We investigated the expression of CDKs and prognosis in breast cancer. Materials and Methods: The Oncomine database examined CDK gene expressions in breast cancer.
X.-J. Bao, L. Wenli, T. Sun, J.-W. Wang, X.-F. Liu, M.-X. Li, Z.-W. Zhang   +6 more
doaj   +2 more sources

Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation

Frontiers in Oncology, 2021
With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars. Hub genes that determine the phenotypes of CRC become essential for targeted therapy. In the present study, the
Yingyu Zhou, Yuki Morita, Satoshi Hachimura   +2 more
exaly   +3 more sources

Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells [PDF]

The EMBO Journal
CDK7 has emerged as a cancer target because of its pivotal roles in cell cycle progression and transcription. Several CDK7 inhibitors (CDK7i) are now in clinical evaluation.
Chun-Fui Lai, Victoria I Cushing, Ellen Olden, Charlotte L Bevan, R Charles Coombes, Basil J Greber, Laki Buluwela, Simak Ali   +7 more
doaj   +2 more sources

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase [PDF]

Science
Victoria I Cushing, Sophie L Williams, Theodoros I Roumeliotis   +2 more
exaly   +2 more sources

Comprehensive Analysis of Role of Cyclin-Dependent Kinases Family Members in Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundCyclin-dependent kinases (CDKs) are cell cycle regulators, and abnormal activation can accelerate tumor cell proliferation. However, The relation between CDKs dysregulation to colorectal cancer incidence and progression have not been examined ...
Liping Guan, Liping Guan, Yuanyuan Tang, Guanghua Li, Zhao Qin, Shaoshan Li   +5 more
doaj   +1 more source

Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases

Pharmaceuticals, 2023
Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
doaj   +1 more source

Effect of a community based social marketing strategy on the uptake of clean delivery kits in peri-urban communities of Karachi, Pakistan

BMC Pregnancy and Childbirth, 2022
Background Pakistan has one of the highest neonatal and maternal mortality rates in the world. Use of clean delivery kits (CDK) at time of delivery improves maternal and newborn outcome.
Asra Usmani, Shazia Sultana, Imran Nisar, Shehla Zaidi, Imtiaz Jehan, Anita Zaidi   +5 more
doaj   +1 more source

A review on the role of cyclin dependent kinases in cancers

Cancer Cell International, 2022
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad, Nader Akbari Dilmaghani   +7 more
doaj   +1 more source

Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

Cell Reports, 2020
Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations.
Weiwei Shan, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang, Lin Zhang   +18 more
doaj   +1 more source