Results 41 to 50 of about 50,848 (283)
Heliyon, 2022 Introduction: Cell cycle-associated cyclin-dependent kinases (ccCDKs) are essential regulators known to control cell division and facilitate tumorigenesis and progression.
Yean Huang +8 more
doaj +1 more source
The role of CDK in the initiation step of DNA replication in eukaryotes
Cell Division, 2007 Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication.
Tak Yon-Soo +2 more
doaj +1 more source
, 2021 With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars. Hub genes that determine the phenotypes of CRC become essential for targeted therapy. In the present study, the
Takuya Miyakawa (246192) +6 more
core +1 more source
Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus. [PDF]
PLoS ONE, 2013 Cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases essential for cell cycle progression. Herein, we describe the participation of CDKs in the physiology of Rhipicephalus microplus, the southern cattle tick and an important disease ...
Helga Gomes +12 more
doaj +1 more source
Unveiling The Noncanonical Activation Mechanism of CDKs: Insights From Recent Structural Studies [PDF]
, 2023 The Cyclin-dependent kinases (CDKs) play crucial roles in a range of essential cellular processes. While the classical two-step activation mechanism is generally applicable to cell cycle-related CDKs, both CDK7 and CDK8, involved in transcriptional ...
Tsai, Kuang-Lei, Li, Tao, Tang, Hui-Chi
core +1 more source
Two co-evolutionary scenarios between human cyclins and human CDKs.
, 2023 The co-phylogenies were realized using Jane [170] (A) and TreeMap [174] (B). (A) Cyclins (black lines) and CDKs (blue lines) that cluster together depict an interaction (the cyclin can bind the CDK to activate it).
Emma U. Hammarlund (10966182) +3 more
core +1 more source
Pharmaceutics, 2021 Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap +4 more
doaj +1 more source
The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression. [PDF]
Discov OncolBackground Prostate cancer (PCa) is one of the leading causes of morbidity and mortality in the world, it becomes imperative to investigate the molecular mechanisms underlying practical therapeutic approaches. Cyclin-dependent kinases (CDKs) are critical
Farjami Z +4 more
europepmc +2 more sources
The origin of CDK regulation [PDF]
Nature Cell Biology, 2001 The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.
Li, Anatoliy, Blow, J. Julian
openaire +3 more sources
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources