Results 41 to 50 of about 27,135 (258)

Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

Biomolecules, 2020
From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1−6) belonging to the group of prenylated polyphenols.
Sergey A. Dyshlovoy, Darya Tarbeeva, Sergey Fedoreyev, Tobias Busenbender, Moritz Kaune, Marina Veselova, Anatoliy Kalinovskiy, Jessica Hauschild, Valeria Grigorchuk, Natalya Kim, Carsten Bokemeyer, Markus Graefen, Petr Gorovoy, Gunhild von Amsberg   +13 more
doaj   +1 more source

CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients

International Journal of General Medicine, 2022
Dan Wang,1,* Yanhong Zhou,2,* Li Hua,2 Jiaxiang Li,2 Ni Zhu,2 Yifei Liu2 1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, HuBei, People’s Republic of China; 2School of Stomatology and ...
Wang D, Zhou Y, Hua L, Li J, Zhu N, Liu Y   +5 more
doaj  

CDKs and the yeast-hyphal decision [PDF]

, 2020
Fungal cells exist in a diverse range of morphologies. Some species, such as Candida albicans, are dimorphic capable of growing either in a yeast-like form or as a hypha. Cyclindependent kinases (CDKs) have long been thought to play a central role in the
Yue Wang
core  

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. [PDF]

PLoS ONE, 2012
Neutrophils are the most abundant leukocyte and play a central role in the immune defense against rapidly dividing bacteria. However, they are also the shortest lived cell in the blood with a lifespan in the circulation of 5.4 days.
Keqing Wang, Peter Hampson, Jon Hazeldine, Vladimir Krystof, Miroslav Strnad, Paul Pechan, Janet M   +6 more
doaj   +1 more source

Structures of active CDKs and imidazole inhibitors.

, 2013
(A) CDK2/cyclinE complex, (B) CDK5/p25 complex, (C) cis-OH or cis-N-acetyl inhibitor, and (D) trans-OH inhibitor. In (A) and (B), CDKs are shown in green and the activators are shown in cyan.
Soumya Lipsa Rath (458566), Sanjib Senapati (148857)   +1 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.

PLoS Genetics, 2020
During metazoan development, the cell cycle is remodelled to coordinate proliferation with differentiation. Developmental cues cause dramatic changes in the number and timing of replication initiation events, but the mechanisms and physiological ...
Vincent Gaggioli, Manuela R Kieninger, Anna Klucnika, Richard Butler, Philip Zegerman   +4 more
doaj   +1 more source

CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets

, 2020
Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology.
Munir R Tanas, Rebecca D Dodd, Dawn E Quelle, Varun Monga, Jordan L Kohlmeyer, David J Gordon   +5 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source