Results 61 to 70 of about 50,848 (283)

CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients

International Journal of General Medicine, 2022
Dan Wang,1,* Yanhong Zhou,2,* Li Hua,2 Jiaxiang Li,2 Ni Zhu,2 Yifei Liu2 1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, HuBei, People’s Republic of China; 2School of Stomatology and ...
Wang D, Zhou Y, Hua L, Li J, Zhu N, Liu Y   +5 more
doaj  

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1. [PDF]

FEBS J
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
López-Hernández MN, Guerrero-Molina ED, Martínez-Ortega U, Lara-Núñez A, Vázquez-Ramos JM.   +4 more
europepmc   +2 more sources

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

ACS Chemical Biology, 2014
We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of the ATP-binding sites of cyclin-dependent kinase (CDK) subfamily members in a range of activation states.
A. Echalier, A. J. Hole, G. Lolli, J. Endicott, M. Noble   +4 more
semanticscholar   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. [PDF]

PLoS ONE, 2012
Neutrophils are the most abundant leukocyte and play a central role in the immune defense against rapidly dividing bacteria. However, they are also the shortest lived cell in the blood with a lifespan in the circulation of 5.4 days.
Keqing Wang, Peter Hampson, Jon Hazeldine, Vladimir Krystof, Miroslav Strnad, Paul Pechan, Janet M   +6 more
doaj   +1 more source

Controlling DNA-end resection: a new task for CDKs

Frontiers in Genetics, 2013
DNA double-strand breaks (DSBs) are repaired by two major pathways: homologous recombination (HR) and non-homologous end-joining (NHEJ). The choice between HR and NHEJ is highly regulated during the cell cycle.
Lorenza P. Ferretti, Lorenzo Lafranchi, A. Sartori   +2 more
semanticscholar   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.

PLoS Genetics, 2020
During metazoan development, the cell cycle is remodelled to coordinate proliferation with differentiation. Developmental cues cause dramatic changes in the number and timing of replication initiation events, but the mechanisms and physiological ...
Vincent Gaggioli, Manuela R Kieninger, Anna Klucnika, Richard Butler, Philip Zegerman   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source