Results 51 to 60 of about 50,848 (283)

Quantifying CDK inhibitor selectivity in live cells

Nature Communications, 2020
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs.
Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers   +16 more
doaj   +1 more source

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion

Diabetes, 2015
β-Cell regeneration is a key goal of diabetes research. Progression through the cell cycle is associated with retinoblastoma protein (pRb) inactivation via sequential phosphorylation by the “early” cyclins and cyclin-dependent kinases (cdks) (d-cyclins ...
Shiwani Tiwari, C. Roel, Rachel C. Wills, Gabriella P. Casinelli, M. Tanwir, K. Takane, N. Fiaschi-Taesch   +6 more
semanticscholar   +1 more source

Dietary Selenium Supplementation Modulates Proliferative Gene Regulators Through Attenuating Cell Cycle Inhibition on Late G1/S Transition in Pre-Pubertal Goat Testis

Journal of Bioresource Management
Selenium (Se) is essential for normal gonadal improvement in prepubertal male goat. Thus hypothesized that dietary Se may influence late G1/S through M-phase gene networks in the testis, thereby advancing pre-pubertal testicular development via ...
Muhammad Awais Soomro, Moolchand Malhi, Tarique Ahmed Khokhar, Faiz Muhammad Khand, Zafar Ali Khoso, Maria Sardar, Muhammad Mohsen Rahimoon, Awais Bin Shahid, Muhammad Anees Memon, Nabi Bux Solangi, Jawed Ali Dhiloo   +10 more
doaj   +1 more source

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

Nature Communications, 2014
Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. Although CDKs are known to control initiation of resection, their role in regulating long-range resection remains ...
N. Tomimatsu, B. Mukherjee, M. C. Hardebeck, Mariya Ilcheva, C. Camacho, J. Harris, M. Porteus, Bertrand Llorente, K. Khanna, S. Burma   +9 more
semanticscholar   +1 more source

Table_1_Fueling the Cycle: CDKs in Carbon and Energy Metabolism.DOCX

, 2018
Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression ...
Maria Solaki (5640326), Jennifer C. Ewald (193822)   +1 more
core   +1 more source

Cyclin dependent kinases and their role in regulation of plant cell cycle

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
doaj   +1 more source

Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

Biomolecules, 2020
From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1−6) belonging to the group of prenylated polyphenols.
Sergey A. Dyshlovoy, Darya Tarbeeva, Sergey Fedoreyev, Tobias Busenbender, Moritz Kaune, Marina Veselova, Anatoliy Kalinovskiy, Jessica Hauschild, Valeria Grigorchuk, Natalya Kim, Carsten Bokemeyer, Markus Graefen, Petr Gorovoy, Gunhild von Amsberg   +13 more
doaj   +1 more source

Regulation of a Cyclin-CDK-CDK Inhibitor Complex by Inositol Pyrophosphates [PDF]

Science, 2007
In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin–cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis. We isolated myo - d -inositol ...
Young-Sam, Lee, Sashidhar, Mulugu, John D, York, Erin K, O'Shea   +3 more
openaire   +2 more sources

CDKs and the yeast-hyphal decision [PDF]

, 2020
Fungal cells exist in a diverse range of morphologies. Some species, such as Candida albicans, are dimorphic capable of growing either in a yeast-like form or as a hypha. Cyclindependent kinases (CDKs) have long been thought to play a central role in the
Yue Wang
core  

Image_1_Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation.pdf

, 2021
With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars. Hub genes that determine the phenotypes of CRC become essential for targeted therapy. In the present study, the
Takuya Miyakawa (246192), Yingyu Zhou (8981303), Sachiko Takahashi (796003), Xuyang Li (11431426), Masaru Tanokura (29888), Yuki Morita (6017603), Satoshi Hachimura (512477)   +6 more
core   +1 more source