Results 31 to 40 of about 50,848 (283)

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions

Asian Pacific Journal of Cancer Biology, 2020
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq   +5 more
doaj   +1 more source

Structural Basis of T-Loop–Independent Recognition and Activation of CDKs by the CDK-Activating Kinase [PDF]

Science
Norman Davey, Basil J. Greber, Theodoros I Roumeliotis   +2 more
exaly   +2 more sources

Sequence comparison of CDK9 and other CDKs.

, 2022
Amino acid alignments of CDKs were performed using Clustal W. The key amino acid residues constituting the local structure surrounding 127 are shown in boxes. (TIF)
Takashi Okamoto (433928), Kaori Asamitsu (433926), Takatsugu Hirokawa (59421)   +2 more
core   +1 more source

Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation

Scientific Reports, 2023
Cell-cycle control is accomplished by cyclin-dependent kinases (CDKs), motivating extensive research into CDK targeting small-molecule drugs as cancer therapeutics.
Kyle Ford, Brenton P. Munson, Samson H. Fong, Rebecca Panwala, Wai Keung Chu, Joseph Rainaldi, Nongluk Plongthongkum, Vinayagam Arunachalam, Jarek Kostrowicki, Dario Meluzzi, Jason F. Kreisberg, Kristen Jensen-Pergakes, Todd VanArsdale, Thomas Paul, Pablo Tamayo, Kun Zhang, Jadwiga Bienkowska, Prashant Mali, Trey Ideker   +18 more
doaj   +1 more source

Cyclo(Pro-Tyr) Suppresses Breast Cancer Cell Proliferation Through Modulation of Cyclin-Dependent Kinase Signaling: An In Silico and In Vitro Study [PDF]

EPJ Web of Conferences
Dysregulated cell-cycle progression is a central driver of breast cancer proliferation and is largely orchestrated by cyclin-dependent kinases (CDKs) and their regulatory cyclins. Although Cyclo(Pro-Tyr), a bioactive cyclic dipeptide, has been previously
Balachandran Shana, Arumugam Madan Kumar, Michael Infanta, Rajesh Vijayavarsine   +3 more
doaj   +1 more source

Can Clean Delivery Kits Prevent Infections? Lessons from Traditional Birth Attendants in Nigeria

Annals of Global Health, 2023
Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to
Adediwura Oladunni Arowosegbe, Iyabode Olabisi Dedeke, Olufunke Bolatito Shittu, David Ajiboye Ojo, Joy Stephen Amusan, Opeoluwa Iwaloye, Uwemedimo Friday Ekpo   +6 more
doaj   +1 more source

CDK signaling via nonconventional CDK phosphorylation sites

Molecular Biology of the Cell, 2023
Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, respectively. However, more recent evidence suggests that often the CDK phosphorylation events of regulatory importance
Valk, Ervin, Örd, Mihkel, Faustova, Ilona, Loog, Mart   +3 more
openaire   +2 more sources

Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase

Acta Pharmaceutica, 2017
Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its ...
Ahmed Mahmood, Abdul Qadir Muhammad, Imtiaz Shafiq Muhammad, Muddassar Muhammad, Hameed Abdul, Nadeem Arshad Muhammad, Asiri Abdullah M.   +6 more
doaj   +1 more source

Functions of cyclins and CDKs in mammalian gametogenesis†

Biology of Reproduction, 2019
Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of our understanding of their functions has been obtained from studies in single-cell organisms and mitotically proliferating cultured cells.
Jessica Y. Chotiner, D. J. Wolgemuth, P. Wang   +2 more
semanticscholar   +1 more source

Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level

Scientific Reports, 2022
Cyclin-dependent kinases (CDKs) control the progression of the cell cycle. D-type cyclin (CYCD) is generally believed to form a complex with CDK and control the G1/S transition.
Chengcheng He, Jinghui Liang, Zhaoqun Wu, Xianglin Zhuge, Nan Xu, Hailing Yang   +5 more
doaj   +1 more source