Results 31 to 40 of about 27,135 (258)

Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level

Scientific Reports, 2022
Cyclin-dependent kinases (CDKs) control the progression of the cell cycle. D-type cyclin (CYCD) is generally believed to form a complex with CDK and control the G1/S transition.
Chengcheng He, Jinghui Liang, Zhaoqun Wu, Xianglin Zhuge, Nan Xu, Hailing Yang   +5 more
doaj   +1 more source

Verification of cell cycle-associated cyclin-dependent kinases facilitated prostate cancer progression by integrated bioinformatic analysis and experimental validation

Heliyon, 2022
Introduction: Cell cycle-associated cyclin-dependent kinases (ccCDKs) are essential regulators known to control cell division and facilitate tumorigenesis and progression.
Yean Huang, Shuo Lu, Yi Chen, Yunhao Qing, Ruji Wu, Tan Ma, Zixiao Zhang, Yu Wang, Ke Li   +8 more
doaj   +1 more source

Two co-evolutionary scenarios between human cyclins and human CDKs.

, 2023
The co-phylogenies were realized using Jane [170] (A) and TreeMap [174] (B). (A) Cyclins (black lines) and CDKs (blue lines) that cluster together depict an interaction (the cyclin can bind the CDK to activate it).
Emma U. Hammarlund (10966182), Kristian Pietras (84915), Paulina Bolivar (14675341), Florian Jacques (3271500)   +3 more
core   +1 more source

The role of CDK in the initiation step of DNA replication in eukaryotes

Cell Division, 2007
Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication.
Tak Yon-Soo, Tanaka Seiji, Araki Hiroyuki   +2 more
doaj   +1 more source

Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus. [PDF]

PLoS ONE, 2013
Cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases essential for cell cycle progression. Herein, we describe the participation of CDKs in the physiology of Rhipicephalus microplus, the southern cattle tick and an important disease ...
Helga Gomes, Nelilma C Romeiro, Gloria R C Braz, Eduardo Alves Gamosa de Oliveira, Camilla Rodrigues, Rodrigo Nunes da Fonseca, Naftaly Githaka, Masayoshi Isezaki, Satoru Konnai, Kazuhiko Ohashi, Itabajara da Silva Vaz, Carlos Logullo, Jorge Moraes   +12 more
doaj   +1 more source

Oncogenic and Tumor Suppressive Components of the Cell Cycle in Breast Cancer Progression and Prognosis

Pharmaceutics, 2021
Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee   +4 more
doaj   +1 more source

Regulation of a Cyclin-CDK-CDK Inhibitor Complex by Inositol Pyrophosphates [PDF]

Science, 2007
In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin–cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis. We isolated myo - d -inositol ...
Young-Sam, Lee, Sashidhar, Mulugu, John D, York, Erin K, O'Shea   +3 more
openaire   +2 more sources

Table_1_Fueling the Cycle: CDKs in Carbon and Energy Metabolism.DOCX

, 2018
Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression ...
Maria Solaki (5640326), Jennifer C. Ewald (193822)   +1 more
core   +1 more source

Quantifying CDK inhibitor selectivity in live cells

Nature Communications, 2020
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs.
Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers   +16 more
doaj   +1 more source

Cyclin dependent kinases and their role in regulation of plant cell cycle

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
doaj   +1 more source