Results 11 to 20 of about 24,207 (211)
Frontiers in Oncology, 2021 Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions, most importantly cell division and transcription, and their dysregulations have been implicated as prominent drivers of tumorigenesis.
Abel Tesfaye Anshabo +3 more
doaj +1 more source
Asian Pacific Journal of Cancer Biology, 2020 Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah +5 more
doaj +1 more source
Scientific Reports, 2023 Cell-cycle control is accomplished by cyclin-dependent kinases (CDKs), motivating extensive research into CDK targeting small-molecule drugs as cancer therapeutics.
Kyle Ford +18 more
doaj +1 more source
Can Clean Delivery Kits Prevent Infections? Lessons from Traditional Birth Attendants in Nigeria
Annals of Global Health, 2023 Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to
Adediwura Oladunni Arowosegbe +6 more
doaj +1 more source
Cyclo(Pro-Tyr) Suppresses Breast Cancer Cell Proliferation Through Modulation of Cyclin-Dependent Kinase Signaling: An In Silico and In Vitro Study [PDF]
EPJ Web of ConferencesDysregulated cell-cycle progression is a central driver of breast cancer proliferation and is largely orchestrated by cyclin-dependent kinases (CDKs) and their regulatory cyclins. Although Cyclo(Pro-Tyr), a bioactive cyclic dipeptide, has been previously
Balachandran Shana +3 more
doaj +1 more source
Fueling the Cycle: CDKs in Carbon and Energy Metabolism
Frontiers in Cell and Developmental Biology, 2018 Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression ...
Maria Solaki, Jennifer C. Ewald
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
CDK signaling via nonconventional CDK phosphorylation sites
Molecular Biology of the Cell, 2023 Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, respectively.
Valk, Ervin +3 more
openaire +2 more sources
Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase
Acta Pharmaceutica, 2017 Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its ...
Ahmed Mahmood +6 more
doaj +1 more source
Scientific Reports, 2022 Cyclin-dependent kinases (CDKs) control the progression of the cell cycle. D-type cyclin (CYCD) is generally believed to form a complex with CDK and control the G1/S transition.
Chengcheng He +5 more
doaj +1 more source