Results 11 to 20 of about 50,848 (283)
Fueling the Cycle: CDKs in Carbon and Energy Metabolism [PDF]
Frontiers in Cell and Developmental Biology, 2018 Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression ...
Maria Solaki, Jennifer C. Ewald
doaj +3 more sources
Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs
Molecular CancerIn cells, signal transduction heavily relies on the intricate regulation of protein kinases, which provide the fundamental framework for modulating most signaling pathways.
Javad Karimbayli +3 more
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Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs [PDF]
BMC Genomics, 2004 Background Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription.
Stiller John W, Guo Zhenhua
doaj +4 more sources
The Role of CDKs and CDKIs in Murine Development [PDF]
International Journal of Molecular Sciences, 2020 Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development.
G. J. Campbell +2 more
semanticscholar +7 more sources
The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma
International Journal of Molecular Sciences, 2018 The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition
Balbina García-Reyes +7 more
semanticscholar +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised.
Xin Wang +11 more
semanticscholar +3 more sources
The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma
Cancer Metastasis Review, 2016 Uncontrolled proliferation and cell growth is the hallmark of many different malignant diseases, including sarcomas. Cyclin-dependent kinases (CDKs) are members of the serine/threonine protein kinase family and play crucial roles in tumor cell ...
Yun-Fei Liao +4 more
semanticscholar +2 more sources
CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets
International Journal of Molecular Sciences, 2020 Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology.
Jordan L Kohlmeyer +5 more
semanticscholar +2 more sources
Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues
npj Precision OncologyEssential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer.
H. Marei +7 more
semanticscholar +2 more sources
Dual role of CDKs in DNA repair: to be, or not to be.
DNA Repair, 2009 The maintenance of genome integrity is essential for the regulation of cell proliferation and differentiation. DNA must be accurately duplicated and segregated to daughter cells at cell division, a process that is primarily regulated by cyclin-dependent ...
K. Yata, Fumiko Esashi
semanticscholar +2 more sources