Results 11 to 20 of about 27,135 (258)

Fueling the Cycle: CDKs in Carbon and Energy Metabolism [PDF]

Frontiers in Cell and Developmental Biology, 2018
Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression ...
Maria Solaki, Jennifer C. Ewald
doaj   +2 more sources

Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs

BMC Genomics, 2004
Background Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription.
Stiller John W, Guo Zhenhua
doaj   +3 more sources

Synthesis, structure analysis, Hirshfeld surface studies, molecular docking studies against cyclin-dependent kinases (CDKs) of sulfonamide decorated N6-benzyl aminopurines for cancer treatment

Results in Chemistry
Cyclin-dependent kinases (CDKs) are recognized as the primary regulators of the cell cycle. CDKs are over-expressed in various types of cancer. Inhibiting CDKs with small molecules can reduce tumor growth and benefit cancer patients. In the current study,
Sivakrishna Narra, Nethaji Munirathinam
doaj   +2 more sources

Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs

Molecular Cancer
In cells, signal transduction heavily relies on the intricate regulation of protein kinases, which provide the fundamental framework for modulating most signaling pathways.
Javad Karimbayli, Ilenia Pellarin, Barbara Belletti, Gustavo Baldassarre   +3 more
doaj   +2 more sources

Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses

BMC Genomics
In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica ...
Fengxiao Lv, Xinfan Ge, Yaqing Chang, Zhenlin Hao   +3 more
doaj   +2 more sources

The Role of CDKs and CDKIs in Murine Development

, 2020
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development.
Grace Jean Campbell, Emma Langdale Hands, Mathew Van de Pette   +2 more
core   +2 more sources

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

Frontiers in Oncology, 2021
Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions, most importantly cell division and transcription, and their dysregulations have been implicated as prominent drivers of tumorigenesis.
Abel Tesfaye Anshabo, Robert Milne, Shudong Wang, Hugo Albrecht   +3 more
doaj   +1 more source

The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression. [PDF]

Discov Oncol
Background Prostate cancer (PCa) is one of the leading causes of morbidity and mortality in the world, it becomes imperative to investigate the molecular mechanisms underlying practical therapeutic approaches. Cyclin-dependent kinases (CDKs) are critical
Farjami Z, Mohammadzadeh Z, Saifi B, Nezhad MT, Akbarin MM.   +4 more
europepmc   +2 more sources

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions

Asian Pacific Journal of Cancer Biology, 2020
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq   +5 more
doaj   +1 more source

Sequence comparison of CDK9 and other CDKs.

, 2022
Amino acid alignments of CDKs were performed using Clustal W. The key amino acid residues constituting the local structure surrounding 127 are shown in boxes. (TIF)
Takashi Okamoto (433928), Kaori Asamitsu (433926), Takatsugu Hirokawa (59421)   +2 more
core   +1 more source