Results 21 to 30 of about 27,135 (258)
Scientific Reports, 2023 Cell-cycle control is accomplished by cyclin-dependent kinases (CDKs), motivating extensive research into CDK targeting small-molecule drugs as cancer therapeutics.
Kyle Ford +18 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Can Clean Delivery Kits Prevent Infections? Lessons from Traditional Birth Attendants in Nigeria
Annals of Global Health, 2023 Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to
Adediwura Oladunni Arowosegbe +6 more
doaj +1 more source
CDK signaling via nonconventional CDK phosphorylation sites
Molecular Biology of the Cell, 2023 Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, respectively.
Valk, Ervin +3 more
openaire +2 more sources
Inhibitory effects of compound 127 on various CDKs.
, 2022 Inhibitory effects of compound 127 on various CDKs.
Takashi Okamoto (433928) +2 more
core +1 more source
Inhibitory effects of compound 1804 on various CDKs.
, 2022 Inhibitory effects of compound 1804 on various CDKs.
Takashi Okamoto (433928) +2 more
core +1 more source
Cyclo(Pro-Tyr) Suppresses Breast Cancer Cell Proliferation Through Modulation of Cyclin-Dependent Kinase Signaling: An In Silico and In Vitro Study [PDF]
EPJ Web of ConferencesDysregulated cell-cycle progression is a central driver of breast cancer proliferation and is largely orchestrated by cyclin-dependent kinases (CDKs) and their regulatory cyclins. Although Cyclo(Pro-Tyr), a bioactive cyclic dipeptide, has been previously
Balachandran Shana +3 more
doaj +1 more source
Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase
Acta Pharmaceutica, 2017 Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its ...
Ahmed Mahmood +6 more
doaj +1 more source
Comparative structural study of 20 human CDKs using bioinformatics tools
, 2021 As Quinases dependentes de Ciclinas (CDKs) são serina/treonina quinases, cuja atividade é modulada pela interação com ciclinas e sucessivas fosforilações que ocorrem no complexo.
Galera, Kaique Dias
core +1 more source
The origin of CDK regulation [PDF]
Nature Cell Biology, 2001 The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.
Li, Anatoliy, Blow, J. Julian
openaire +3 more sources