Results 21 to 30 of about 24,207 (211)

Verification of cell cycle-associated cyclin-dependent kinases facilitated prostate cancer progression by integrated bioinformatic analysis and experimental validation

Heliyon, 2022
Introduction: Cell cycle-associated cyclin-dependent kinases (ccCDKs) are essential regulators known to control cell division and facilitate tumorigenesis and progression.
Yean Huang, Shuo Lu, Yi Chen, Yunhao Qing, Ruji Wu, Tan Ma, Zixiao Zhang, Yu Wang, Ke Li   +8 more
doaj   +1 more source

The role of CDK in the initiation step of DNA replication in eukaryotes

Cell Division, 2007
Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication.
Tak Yon-Soo, Tanaka Seiji, Araki Hiroyuki   +2 more
doaj   +1 more source

Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus. [PDF]

PLoS ONE, 2013
Cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases essential for cell cycle progression. Herein, we describe the participation of CDKs in the physiology of Rhipicephalus microplus, the southern cattle tick and an important disease ...
Helga Gomes, Nelilma C Romeiro, Gloria R C Braz, Eduardo Alves Gamosa de Oliveira, Camilla Rodrigues, Rodrigo Nunes da Fonseca, Naftaly Githaka, Masayoshi Isezaki, Satoru Konnai, Kazuhiko Ohashi, Itabajara da Silva Vaz, Carlos Logullo, Jorge Moraes   +12 more
doaj   +1 more source

Oncogenic and Tumor Suppressive Components of the Cell Cycle in Breast Cancer Progression and Prognosis

Pharmaceutics, 2021
Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee   +4 more
doaj   +1 more source

The origin of CDK regulation [PDF]

Nature Cell Biology, 2001
The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.
Li, Anatoliy, Blow, J. Julian
openaire   +3 more sources

Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs

BMC Genomics, 2004
Background Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription.
Stiller John W, Guo Zhenhua
doaj   +1 more source

Quantifying CDK inhibitor selectivity in live cells

Nature Communications, 2020
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs.
Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers   +16 more
doaj   +1 more source

Cyclin dependent kinases and their role in regulation of plant cell cycle

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
doaj   +1 more source

Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

Biomolecules, 2020
From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1−6) belonging to the group of prenylated polyphenols.
Sergey A. Dyshlovoy, Darya Tarbeeva, Sergey Fedoreyev, Tobias Busenbender, Moritz Kaune, Marina Veselova, Anatoliy Kalinovskiy, Jessica Hauschild, Valeria Grigorchuk, Natalya Kim, Carsten Bokemeyer, Markus Graefen, Petr Gorovoy, Gunhild von Amsberg   +13 more
doaj   +1 more source

CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients

International Journal of General Medicine, 2022
Dan Wang,1,* Yanhong Zhou,2,* Li Hua,2 Jiaxiang Li,2 Ni Zhu,2 Yifei Liu2 1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, HuBei, People’s Republic of China; 2School of Stomatology and ...
Wang D, Zhou Y, Hua L, Li J, Zhu N, Liu Y   +5 more
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