Results 21 to 30 of about 50,848 (283)

Role of cyclin‐dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway

Hepatology Research, 2019
Liver cancer is the fourth leading cause of cancer related mortality in the world, with hepatocellular carcinoma (HCC) representing the most common primary subtype.
Shen Shen, Dylan C. Dean, Zujiang Yu, Z. Duan   +3 more
semanticscholar   +2 more sources

Synthesis, structure analysis, Hirshfeld surface studies, molecular docking studies against cyclin-dependent kinases (CDKs) of sulfonamide decorated N6-benzyl aminopurines for cancer treatment

Results in Chemistry
Cyclin-dependent kinases (CDKs) are recognized as the primary regulators of the cell cycle. CDKs are over-expressed in various types of cancer. Inhibiting CDKs with small molecules can reduce tumor growth and benefit cancer patients. In the current study,
Sivakrishna Narra, Nethaji Munirathinam
doaj   +2 more sources

Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs.

Methods in molecular biology, 2016
© Springer Science+Business Media, LLC 2016. Multiple Cdks (Cdk4, Cdk6, and Cdk2) and a mitotic Cdk (Cdk1) are involved in cell cycle progression in mammals.
Sanjiv Risal, Deepak Adhikari, Kui Liu
semanticscholar   +2 more sources

Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses

BMC Genomics
In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica ...
Fengxiao Lv, Xinfan Ge, Yaqing Chang, Zhenlin Hao   +3 more
doaj   +2 more sources

When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Disease

International Journal of Molecular Sciences, 2021
Alzheimer’s disease (AD) is a mostly sporadic brain disorder characterized by cognitive decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex whereas Huntington’s disease (HD) is a monogenic inherited disorder ...
S. D'Mello
semanticscholar   +1 more source

Plant CDKs—Driving the Cell Cycle through Climate Change

Plants, 2021
In a growing population, producing enough food has become a challenge in the face of the dramatic increase in climate change. Plants, during their evolution as sessile organisms, developed countless mechanisms to better adapt to the environment and its ...
A. Carneiro, Patrícia da Fonseca Montessoro, A. F. Fusaro, Bruna Gino Araújo, A. Hemerly   +4 more
semanticscholar   +1 more source

Expression pattern and prognostic significance of CDKs in breast cancer: An integrated bioinformatic study

Cancer Biomarkers, 2022
BACKGROUND: Globally, breast cancer (BC) has become one of the most prevalent malignancies and the leading cause of tumor-related deaths among women. Dysregulation of the cell cycle is a well-known hallmark of cancer development and metastasis.
Umar Mehraj, Shazia Sofi, B. Alshehri, M. A. Mir   +3 more
semanticscholar   +1 more source

Inhibitory effects of compound 127 on various CDKs.

, 2022
Inhibitory effects of compound 127 on various CDKs.
Takashi Okamoto (433928), Kaori Asamitsu (433926), Takatsugu Hirokawa (59421)   +2 more
core   +1 more source

Inhibitory effects of compound 1804 on various CDKs.

, 2022
Inhibitory effects of compound 1804 on various CDKs.
Takashi Okamoto (433928), Kaori Asamitsu (433926), Takatsugu Hirokawa (59421)   +2 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source