Results 1 to 10 of about 550,507 (355)

Cyclin-dependent kinases [PDF]

Genome Biology, 2014
SummaryCyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
Marcos Malumbres
openaire   +3 more sources

Cyclin-dependent kinase

Definitions, 2009
Cyclin-dependent eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Researcher Código, Orcid A.1, Situación, Artero Formación, Licenciatura, Grado, Doctorado   +6 more
openaire   +2 more sources

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

Pharmaceutical Biology, 2023
Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu   +4 more
doaj   +1 more source

The Cyclin-dependent kinase 1: more than a cell cycle regulator

British Journal of Cancer, 2023
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade.
Giorgia Massacci, Livia Perfetto, F. Sacco   +2 more
semanticscholar   +1 more source

Exploring cell cycle-mediated regulations of glycolysis in budding yeast

Frontiers in Microbiology, 2023
Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang, Yanfei Zhang, Matteo Barberis, Matteo Barberis, Matteo Barberis   +4 more
doaj   +1 more source

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source

Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma

Kouqiang hemian waike zazhi, 2023
Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and ...
HOU Zeyu, TANG Jinru, LI Longjiang
doaj   +1 more source

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source

Cyclin-dependent kinase inhibitors in malignant hematopoiesis

Frontiers in Oncology, 2022
The cell-cycle is a tightly orchestrated process where sequential steps guarantee cellular growth linked to a correct DNA replication. The entire cell division is controlled by cyclin-dependent kinases (CDKs). CDK activation is balanced by the activating
Alessia Schirripa, Veronika Sexl, Karoline Kollmann   +2 more
doaj   +1 more source