Results 41 to 50 of about 268,841 (309)

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]

, 2014
Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Vázquez-Novelle, María Dolores, Dick, Amalie E., Sansregret, Laurent, Smith, Christopher A., Gerlich, Daniel W., McAinsh, Andrew D., Petronczki, Mark   +6 more
core   +1 more source

Cyclin-dependent kinase inhibitors: efficacy and safety

Медицинский совет, 2019
Breast Cancer is the most common type of cancer worldwide. Scientific advances and new ways of treating have significantly improved the prognosis of breast cancer in recent decades.
I. B. Kononenko, A. V. Snegovoi, V. Yu. Selchuk   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]

, 2003
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A., Weikert, C., Wightman, L., Magyar, J. P., Hans M. Eppenberger, Wagner, E., Eppenberger, H. M., Josef P. Magyar, Lionel Wightman, Daniel A. Dätwyler, Ernst Wagner, Christian Weikert   +11 more
core   +1 more source

Cyclin-dependent kinase control of motile ciliogenesis

eLife, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar, Miranda B Stratton, Maxwell L Saal, Glicella Salazar-De Simone, Xiangyuan Wang, Debra Wolgemuth, Tim Stearns, Jeffrey D Axelrod   +7 more
doaj   +1 more source

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). [PDF]

PLoS ONE, 2015
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis.
Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J Quinn, Alus M Xiaoli, Yan Sun, Morris J Birnbaum, Jeffrey E Pessin, Fajun Yang   +9 more
doaj   +1 more source

Cyclin-dependent kinases: a family portrait [PDF]

Nature Cell Biology, 2009
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Marcos, Malumbres, Edward, Harlow, Tim, Hunt, Tony, Hunter, Jill M, Lahti, Gerard, Manning, David O, Morgan, Li-Huei, Tsai, Debra J, Wolgemuth   +8 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle

npj Systems Biology and Applications, 2017
Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression.
Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis   +10 more
doaj   +1 more source

Design New Compound of Meisoindigo Derivative as Anti Breast Cancer Based on QSAR Approach

Jurnal Kimia Sains dan Aplikasi, 2020
Design new compounds of Meisoindigo using the QSAR approach with semiempirical methods have been successfully made with better biological activity as anti-breast cancer results.
Agus Dwi Ananto, Handa Muliasari, Saprizal Hadisaputra   +2 more
doaj   +1 more source