Results 31 to 40 of about 268,296 (309)

The Role of p27kip1 in the Aggressiveness of Papillary Thyroid Carcinoma: A Clinicopathological Analysis

مجلة كلية الطب
Background: Cell-cycle-regulating proteins, including cyclin-dependent kinase inhibitor 1B p27kip1, have been researched in different malignancies, including thyroid carcinoma, and their association with tumor aggressiveness and recurrence has been ...
Wafaa K. Ibrahim, khitam R. Al-khafaji
doaj   +1 more source

Spy1-activated Cyclin Dependent Kinase 2 Shows Reduced Affinity for Current Synthetic Small Molecule Inhibitors of the CDK2-Cyclin Complex

, 2023
Cyclin-dependent kinases (CDKs) play a key role in activating essential cell biology processes including cellular proliferation. Inappropriate regulation of CDKs has been implicated in driving several different forms of cancer.
John, Hayward, Bre-Anne, Fifield, Lisa, Porter, Daniel, Meister, John, Trant   +4 more
core   +1 more source

Cyclin-dependent kinase control of motile ciliogenesis

eLife, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar, Miranda B Stratton, Maxwell L Saal, Glicella Salazar-De Simone, Xiangyuan Wang, Debra Wolgemuth, Tim Stearns, Jeffrey D Axelrod   +7 more
doaj   +1 more source

Cyclin-Dependent Kinase 5 and Insulin Secretion

, 2008
Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells.
Marko Jevsek, Jevsek, Marko, Slavena A. Mandic, Marjan Rupnik, Christina Bark, Bark, Christina, Berggren, Per-Olof, Mandic, Slavena A., Rupnik, Marjan, Per-Olof Berggren   +9 more
core   +1 more source

Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity [PDF]

, 2017
Coordination of endomembrane biogenesis with cell cycle progression is considered to be important in maintaining cell function during growth and development. We previously showed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH) activity in
Eastmond, Peter J., Adams, N., Kurup, Smita, Craddock, Christian P., Bryant, Fiona M., Hussey, Patrick J., Adams, Nicolette, Kroon, Johan T.M., Craddock, C. P., Hussey, P. J., Kurup, S., Eastmond, P. J., Bryant, F. M., Kroon, J. T. M.   +13 more
core   +1 more source

Effect of vorinostat on INK4 family and HDACs 1, 2, and 3 in pancreatic cancer and hepatocellular carcinoma

Research in Pharmaceutical Sciences, 2021
Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj   +1 more source

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]

, 2014
Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Vázquez-Novelle, María Dolores, Dick, Amalie E., Sansregret, Laurent, Smith, Christopher A., Gerlich, Daniel W., McAinsh, Andrew D., Petronczki, Mark   +6 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cyclin-dependent kinase inhibitors: efficacy and safety

Медицинский совет, 2019
Breast Cancer is the most common type of cancer worldwide. Scientific advances and new ways of treating have significantly improved the prognosis of breast cancer in recent decades.
I. B. Kononenko, A. V. Snegovoi, V. Yu. Selchuk   +2 more
doaj   +1 more source

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). [PDF]

PLoS ONE, 2015
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis.
Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J Quinn, Alus M Xiaoli, Yan Sun, Morris J Birnbaum, Jeffrey E Pessin, Fajun Yang   +9 more
doaj   +1 more source