Results 31 to 40 of about 3,489,964 (290)
Drugs in Context, 2018 In the last 3 years, a novel class of targeted therapy has been approved for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer.
Mariane Teodoro Fernandes +7 more
doaj +1 more source
Cdk6: At the interface of Rb and p53
Molecular & Cellular Oncology, 2018 In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies.
Sofie Nebenfuehr +2 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2021 Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression.
Masumeh Sanaei, Fraidoon Kavoosi
doaj +1 more source
PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1 [PDF]
, 2012 P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported.
Perearnau Garcia, Anna +12 more
core +1 more source
مجلة كلية الطبBackground: Cell-cycle-regulating proteins, including cyclin-dependent kinase inhibitor 1B p27kip1, have been researched in different malignancies, including thyroid carcinoma, and their association with tumor aggressiveness and recurrence has been ...
Wafaa K. Ibrahim, khitam R. Al-khafaji
doaj +1 more source
The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]
, 2012 Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
Madhuri, K +17 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Cyclin-dependent kinase control of motile ciliogenesis
eLife, 2018 Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar +7 more
doaj +1 more source
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). [PDF]
PLoS ONE, 2015 In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis.
Daorong Feng +9 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source