Results 11 to 20 of about 550,507 (355)

A review on the role of cyclin dependent kinases in cancers

Cancer Cell International, 2022
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
S. Ghafouri‐Fard, Tayyebeh Khoshbakht, B. Hussen, Peixin Dong, N. Gassler, M. Taheri, A. Baniahmad, N. A. Dilmaghani   +7 more
semanticscholar   +1 more source

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

Meiotic progression in arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM [PDF]

, 2010
International audienceMeiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation.
Bulankova, Petra, Riehs-Kearnan, Nina, Nowack, Moritz, Schnittger, Arp, Riha, Karel   +4 more
core   +3 more sources

Prediction of cyclin-dependent kinase phosphorylation substrates. [PDF]

PLoS ONE, 2007
Protein phosphorylation, mediated by a family of enzymes called cyclin-dependent kinases (Cdks), plays a central role in the cell-division cycle of eukaryotes.
Emmanuel J Chang, Rashida Begum, Brian T Chait, Terry Gaasterland   +3 more
doaj   +1 more source

Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review.

Pediatric Neurology, 2019
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a developmental encephalopathy caused by pathogenic variants in the gene CDKL5.
H. Olson, S. Demarest, Elia Pestana-Knight, L. Swanson, Sumaiya Iqbal, Sumaiya Iqbal, Dennis Lal, Dennis Lal, H. Leonard, J. Cross, O. Devinsky, T. Benke   +11 more
semanticscholar   +1 more source

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Science, 2019
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy.
Keelan G. Guiley, J. W. Stevenson, Kevin Lou, Krister J. Barkovich, V. Kumarasamy, Tilini U. Wijeratne, K. Bunch, S. Tripathi, E. Knudsen, A. Witkiewicz, K. Shokat, S. M. Rubin   +11 more
semanticscholar   +1 more source

Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]

Anais Brasileiros de Dermatologia, 2016
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira   +5 more
doaj   +1 more source

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]

, 2007
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
Dissmeyer, N., , Nowack, M., Pusch, S., Stals, H., Inzé, D., Grini, P., Schnittger, A.   +7 more
core   +2 more sources

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Virus Research, 2023
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for ...
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall   +12 more
doaj   +1 more source

Palbociclib in breast cancer neoadjuvant setting

Autopsy and Case Reports, 2021
Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer.
Sílvia Alexandra Cabral Duarte, Daniela Silva Pádua de Azevedo, Teresa Tomé Ribeiro Malheiro Sarmento, Marta Verónica Velho Sousa   +3 more
doaj