Results 21 to 30 of about 550,507 (355)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]

, 2014
Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian, Musgrove, Elizabeth A., Sergio, C. Marcelo, Sutherland, Robert L.   +3 more
core   +2 more sources

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells

Tumor Biology, 2018
Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti, Valeria Li Bergolis, Annamaria Piscazzi, Francesca Giannelli, Valentina Condelli, Lorenza Sisinni, Giuseppe Bove, Giovanni Storto, Matteo Landriscina   +8 more
doaj   +1 more source

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Journal of Medicinal Chemistry, 2016
Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly 2 decades due to their widely varied and critical functions within the cell.
Yogesh A Sonawane, Margaret A. Taylor, J. V. Napoleon, Sandeep Rana, Jacob I. Contreras, A. Natarajan   +5 more
semanticscholar   +1 more source

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain

Viruses, 2015
Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification.
Mirjam Steingruber, Eileen Socher, Corina Hutterer, Rike Webel, Tim Bergbrede, Tihana Lenac, Heinrich Sticht, Manfred Marschall   +7 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Complexity in cancer biology: is systems biology the answer?

Cancer Medicine, 2013
Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli, Athanasios G. Papavassiliou, Nikolaos A. Papanikolaou   +2 more
doaj   +1 more source

Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Laboratory Animal Research, 2018
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.
Bo Min Park, Jae-il Roh, Jaehoon Lee, Han-Woong Lee   +3 more
doaj   +1 more source

Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province

Medical Journal of Babylon, 2020
Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes.
Dalya Shakir Al-Owaidi, Moaed E Algazally, Alaa Sadeq Alawaad   +2 more
doaj   +1 more source

Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]

PLoS ONE, 2014
Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla, Elias Utreras, Howard Jaffe, Ashok B Kulkarni   +3 more
doaj   +1 more source

Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny

mBio, 2022
Opportunistic parasites of the Apicomplexa phylum use a variety of division modes built on two types of cell cycles that incorporate two distinctive mechanisms of mitosis: uncoupled from and coupled to parasite budding.
Lauren M. Hawkins, Anatoli V. Naumov, Mrinalini Batra, Changqi Wang, Dale Chaput, Elena S. Suvorova   +5 more
doaj   +1 more source