Results 1 to 10 of about 372,752 (258)
An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2
Chemistry Proceedings, 2021 CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
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Discovery of molecular and genetic mechanisms of cell cycle regulation: 2001 Nobel laureates leland Hartwell, Timothy Hunt and Paul Nurse [PDF]
The Ukrainian Biochemical Journal, 2023 Leland Hartwell, Paul Nurse and Timothy Hunt in 2001 were awarded the Nobel Prize for their discovery of molecular and genetic mechanisms of the cell cycle.
O. P. Matyshevska +3 more
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p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties
Cells, 2021 The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms.
Debora Bencivenga +4 more
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Cells, 2020 Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis of cancer determining uncontrolled cellular proliferation.
F. Montalto, F. De Amicis
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Cell Reports, 2021 Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai +13 more
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Nature, 2020 Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid ...
Mikołaj Słabicki +23 more
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Effects of Icodextrin Solution (Adept®) on Ovarian Cancer Cell Proliferation in an In Vitro Model
Medicina, 2022 Background and objective: Anti-adhesion barriers are currently used during ovarian cancer surgery to decrease adhesion-related morbidity. Adept® (4% icodextrin) solution, a liquid anti-adhesion material, has been widely used during gynecologic surgeries,
Wen-Hsin Chen +5 more
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A Journey through Time on the Discovery of Cell Cycle Regulation
Cells, 2022 All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
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The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells
Mycobiology, 2020 Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line ...
Cheng-Yen Chiang +6 more
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Cells, 2023 Head and neck cancer (HNC) therapy is limited; therefore, new solutions are increasingly being sought among flavonoids, which exhibit numerous biological properties, including potential anticancer activity.
Robert Kubina +5 more
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