Results 11 to 20 of about 241,661 (217)

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer [PDF]

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +2 more sources

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

Restriction Checkpoint Controls Bradyzoite Development in Toxoplasma gondii

Microbiology Spectrum, 2022
Human toxoplasmosis is a life-threatening disease caused by the apicomplexan parasite Toxoplasma gondii. Rapid replication of the tachyzoite is associated with symptomatic disease, while suppressed division of the bradyzoite is responsible for chronic ...
Anatoli V. Naumov, Chengqi Wang, Dale Chaput, Li-Min Ting, Carmelo A. Alvarez, Thomas Keller, Ahmed Ramadan, Michael W. White, Kami Kim, Elena S. Suvorova   +9 more
doaj   +1 more source

Venezuelan Equine Encephalitis Virus Capsid Implicated in Infection-Induced Cell Cycle Delay in vitro

Frontiers in Microbiology, 2018
Venezuelan equine encephalitis virus (VEEV) is a positive sense, single-stranded RNA virus and member of the New World alphaviruses. It causes a biphasic febrile illness that can be accompanied by central nervous system involvement and moderate morbidity
Lindsay Lundberg, Jacque Fontenot, Shih-Chao Lin, Chelsea Pinkham, Brian D. Carey, Catherine E. Campbell, Kylene Kehn-Hall   +6 more
doaj   +1 more source

An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2

Chemistry Proceedings, 2021
CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
doaj   +1 more source

Isolation and characterization of cold inducible genes in carrot by suppression subtractive hybridization

Biologia Plantarum, 2013
Daucus carota is cultivated widely but grows best in cool climates. Suppression subtractive hybridization (SSH) is a PCR based method used to selectively amplify differentially expressed cDNAs and simultaneously suppress non-target cDNA.
S. R. Kumar, S. Anandhan, S. Dhivya, A. Zakwan, R. Sathishkumar   +4 more
doaj   +1 more source

p27^Kip1, an Intrinsically Unstructured Protein with Scaffold Properties

Cells, 2021
The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms.
Debora Bencivenga, Emanuela Stampone, Domenico Roberti, Fulvio Della Ragione, Adriana Borriello   +4 more
doaj   +1 more source

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Cell Reports, 2021
Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng   +13 more
doaj   +1 more source

Cell Cycle-Dependent Expression Dynamics of G1/S Specific Cyclin, Cellulose Synthase and Cellulase in the Dinoflagellate Prorocentrum donghaiense

Frontiers in Microbiology, 2017
Dinoflagellates undergo a typical eukaryotic cell cycle consisting of G1, S, G2, and M phases and some of the typical cell cycle related genes have been computationally identified.
Xinguo Shi, Minglei Ma, Senjie Lin, Senjie Lin   +3 more
doaj   +1 more source

Effects of Icodextrin Solution (Adept^®) on Ovarian Cancer Cell Proliferation in an In Vitro Model

Medicina, 2022
Background and objective: Anti-adhesion barriers are currently used during ovarian cancer surgery to decrease adhesion-related morbidity. Adept® (4% icodextrin) solution, a liquid anti-adhesion material, has been widely used during gynecologic surgeries,
Wen-Hsin Chen, Hao Lin, Hung-Chun Fu, Chen-Hsuan Wu, Ching-Chou Tsai, Yu-Che Ou   +5 more
doaj   +1 more source