Results 11 to 20 of about 372,752 (258)
Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]
EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal ...
Daniel J Donoghue
exaly +7 more sources
Structural insights into the functional diversity of the CDK–cyclin family [PDF]
Open Biology, 2018 Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj +2 more sources
Cyclin E in normal physiology and disease states
Trends in Cell Biology, 2021 E-type cyclins, collectively called cyclin E, represent key components of the core cell-cycle machinery. In mammalian cells two E-type cyclins, E1 and E2, activate the cyclin-dependent kinase CDK2 and drive cell-cycle progression by phosphorylating ...
Chen Chu, Yu Zhou, Piotr Sicinski
exaly +2 more sources
Living with or without cyclins and cyclin-dependent kinases. [PDF]
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins.
C. Sherr, J. M. Roberts
semanticscholar +3 more sources
Rescue of cyclin D1 deficiency by knockin cyclin E [PDF]
Cell, 1999 D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the
Sicinski, Piotr +23 more
core +5 more sources
Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny
mBio, 2022 Opportunistic parasites of the Apicomplexa phylum use a variety of division modes built on two types of cell cycles that incorporate two distinctive mechanisms of mitosis: uncoupled from and coupled to parasite budding.
Lauren M. Hawkins +5 more
doaj +1 more source
Frontiers in Microbiology, 2022 The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng +13 more
doaj +1 more source
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K Teixeira
semanticscholar +1 more source
FEBS Open Bio, 2022 Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first‐line therapy for HER2 ...
Ratih Kusumastuti +6 more
doaj +1 more source
Frontiers in Genetics, 2022 The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck
Kaidiriye Setiwalidi +20 more
doaj +1 more source