Results 1 to 10 of about 74,242 (343)

CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis

Cell Reports, 2023
Summary: Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide.
Mohammed Soutto, Shayan Khalafi, Zheng Chen   +2 more
exaly   +4 more sources

Targeting CDK1 in cancer: mechanisms and implications

npj Precision Oncology, 2023
Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression.
Qiushi Wang, Ann M. Bode, Tianshun Zhang
doaj   +4 more sources

Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors [PDF]

Medical Oncology, 2022
Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in
Shazia Sofi, Umar Mehraj, Hina Qayoom, Shariqa Aisha, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor Ahmad Mir   +6 more
semanticscholar   +4 more sources

Post-translational modification of CDK1–STAT3 signaling by fisetin suppresses pancreatic cancer stem cell properties

Cell & Bioscience, 2023
Background Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in ...
Xiaodong Xu, Yimin Ding, Junbin Jin, Chengjie Xu, Wenyi Hu, Songtao Wu, Guoping Ding, Rui Cheng, Liping Cao, Shengnan Jia   +9 more
doaj   +2 more sources

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4‐mediated Ferroptosis in Colorectal Cancer

Advanced Science, 2023
Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent drug resistance limits its therapeutic efficacy in patients.
Weihao Li, Chi Zhou
exaly   +2 more sources

CDK1 serves as a potential prognostic biomarker and target for lung cancer

Journal of International Medical Research, 2020
Objective Evidence from cell and mouse models and human tissues suggests that cyclin dependent kinase 1 (CDK1) is involved in lung cancer (LC) tumorigenesis.
Mingyao Li, Fenyi He, Zhanchun Zhang, Zhenfei Xiang, Danfei Hu   +4 more
doaj   +2 more sources

Phosphoproteome Remodeling upon CDK1 Inhibition Restricts HSV-1 IE Gene Transcription and Replication [PDF]

Cells
Cyclin-dependent kinase 1 (CDK1) regulates multiple cellular processes that HSV-1 can exploit to promote its own replication, particularly during the early steps of lytic infection.
Maxim S. Rodzkin, Drew R. Honeycutt, David J. Davido   +2 more
doaj   +2 more sources

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer

Acta Biochimica et Biophysica Sinica, 2022
Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan, Xu Jing, Wang Yanan, Gan Mingxi, Hu Qifan, Wang Jianbin, Han Tianyu   +6 more
doaj   +2 more sources

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Cell Chemical Biology, 2019
Summary Dysregulation of the cell cycle characterizes many cancer subtypes, providing a rationale for developing cyclin-dependent kinase (CDK) inhibitors. Potent CDK2 inhibitors might target certain cancers in which CCNE1 is amplified.
Natalie J Tatum, Jane A Endicott, Martin E M Noble   +2 more
exaly   +2 more sources

The circular RNA circ-Ccnb1 dissociates Ccnb1/Cdk1 complex suppressing cell invasion and tumorigenesis

Cancer Letters, 2019
Circular RNAs represent a large class of non-coding RNAs that are extensively expressed in mammals. However, the functions of circular RNAs are largely unknown.
Faryal Mehwish Awan, Burton B Yang
exaly   +2 more sources