Results 21 to 30 of about 74,242 (343)
Computational identification of potential inhibitors targeting cdk1 in colorectal cancer
bioRxiv, 2023 Despite improved treatment options, colorectal cancer (CRC) remains a huge public health concern with a significant impact on affected individuals. Cell cycle dysregulation and overexpression of certain regulators and checkpoint activators are important ...
U. C. Ogbodo +9 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 Ovarian cancer is the deadliest gynecological malignancy of the reproductive organs in the United States. Cyclin-dependent kinase 1 (CDK1) is an important cell cycle regulatory protein that specifically controls the G2/M phase transition of the cell ...
Yu Huang +15 more
semanticscholar +1 more source
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Journal of experimental & clinical cancer research : CR, 2023 Background Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC).
Zhi-tao Han +15 more
semanticscholar +1 more source
When CDK1 Rides the Telomere Cycle [PDF]
Molecular Cell, 2006 Reconstitution of telomeric DNA at each cell division implies the coordination of DNA semiconservative replication with several processing events still poorly understood. Two reports published recently in Molecular Cell show that a cell-cycle cyclin-dependent kinase, Cdk1p, is required to create the cell-cycle-regulated overhang ().
Teixeira, M.T., Gilson, Eric
openaire +3 more sources
International Journal of Molecular Sciences, 2022 The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle.
J. Enserink, Pierre Chymkowitch
semanticscholar +1 more source
Inhibition of CDK1 activity by sumoylation [PDF]
Biochemical and Biophysical Research Communications, 2016 Sumoylation (a covalent modification by Small Ubiquitin-like Modifiers or SUMO proteins) has been implicated in the regulation of various cellular events including cell cycle progression. We have recently identified CDK1, a master regulator of mitosis and meiosis, as a SUMO target both in vivo and in vitro, supporting growing evidence concerning a ...
Yuxuan Xiao +4 more
openaire +2 more sources
CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
Nature Cell Biology, 2022 The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome segregation.
Nan-Peng Chen, Jonas Aretz, R. Fässler
semanticscholar +1 more source
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)
Cancers, 2022 Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M checkpoint, is expressed in many cells and plays an important role in cell cycle control. However, CDK1 expression is substantially increased in many tumors of diverse
Xuanyou Liu, Hao Wu, Zhenguo Liu
semanticscholar +1 more source
CDK1, the Other ‘Master Regulator’ of Autophagy [PDF]
Trends in Cell Biology, 2021 Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies ...
Richard I, Odle +3 more
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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]
PLoS Biology, 2007 Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist +3 more
doaj +1 more source