Results 21 to 30 of about 46,551 (257)

CDK1 Phosphorylates KAT8 at Ser348 to Stabilize the MSL Complex and Promote H4K16 Acetylation in Non-Small Cell Lung Cancer [PDF]

Cells
Cyclin-dependent kinase 1 (CDK1) is frequently upregulated in multiple cancers and plays a central role in cell cycle progression and tumorigenesis. However, whether CDK1 directly regulates the histone acetyltransferase KAT8 (also known as MOF) in non ...
Jinmeng Chu, Qingzhi Zhao, Hui Ye, Meixu Li, Yizhen Wang, Tiantian Xu, Yong Cai, Jingji Jin   +7 more
doaj   +2 more sources

Chromosome alignment and Kif18A action rely on spindle-localized control of Cdk1 activity [PDF]

Frontiers in Cell and Developmental Biology
IntroductionDuring mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells.
Angela Flavia Serpico, Caterina Pisauro, Asia Trano, Domenico Grieco, Domenico Grieco   +4 more
doaj   +2 more sources

CDK1 drives SOX9-mediated chemotherapeutic resistance in gastric cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Background Gastric carcinoma ranks as the fifth most common cause of cancer-related mortality globally. Chemoresistance remains a critical barrier to treatment efficacy, driving poor survival outcomes in gastric cancer patients. Cyclin-dependent kinase 1
Marwah Al-Mathkour, Zheng Chen, Julio Poveda, Longlong Cao, Oliver G. McDonald, Dunfa Peng, Mohammed Soutto, Zhibin Chen, Heng Lu, Yan Guo, Shria Kumar, Alexander Zaika, Silvia Giordano, Shoumin Zhu, Wael El-Rifai   +14 more
doaj   +2 more sources

Bioinformatics Analysis Reveals CDK1 and DLGAP5 as Key Modulators of Tumor Immune Cell Infiltration in Hepatocellular Carcinoma [PDF]

Cancer Management and Research
Jiajing Li,1 Qi Liu,2 Ting Zhang,2 Qian Du3 1The Diagnostics Laboratory, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’
Li J, Liu Q, Zhang T, Du Q
doaj   +1 more source

HAND2-AS1 plays a tumor-suppressive role in hepatoblastoma through the negative regulation of CDK1

Heliyon
Objective: Hepatoblastoma (HB) is the most commonly seen pediatric liver malignancy. The preliminary experiment of our research group found that cyclin dependent kinase 1 (CDK1) was upregulated in HB.
Keke Chen, Yalan You, Wenfang Tang, Xin Tian, Chengguang Zhu, Zexi Yin, Minhui Zeng, Xiangling He   +7 more
doaj   +2 more sources

COLD ATMOSPHERIC PLASMA TREATMENT MODULATES THE EXPRESSION OF cdk1, tnfα AND tp53 GENES IN HUMAN OSTEOSARCOMA CELLS

Journal of Experimental and Molecular Biology, 2023
Osteosarcoma (OS), a malignancy primarily affecting children and adolescents, is the most frequently encountered malignant, non-hematologic, bone tumor.
Alexandru Bogdan Stache, Ilarion Mihăilă, Ioana Cristina Gerber, Loredana Mihaiela Dragoș, Cosmin Teodor Mihai, Iuliu Cristian Ivanov, Ionuț Topală, Dragoș-Lucian Gorgan   +7 more
doaj   +1 more source

The effect of vitrification after warming on the expressions of p38, CDK1, and cyclin B in immature goat oocytes followed by in vitro maturation [PDF]

Veterinary World, 2020
Background and Aim: The combination of vitrification techniques and in vitro maturation can reduce oocyte competence. Mitogen-activated protein kinase and maturation-promoting factor are significant in oocyte meiotic maturation regulation.
A. A. Muhammad Nur Kasman, Budi Santoso, Widjiati Widjiati   +2 more
doaj   +1 more source

CENP-C Phosphorylation by CDK1 in vitro [PDF]

BIO-PROTOCOL, 2021
Accurate chromosome segregation during mitosis requires the kinetochore, a large protein complex, which makes a linkage between chromosomes and spindle microtubes. An essential kinetochore component, CENP-C, is phosphorylated by Cyclin-B-Cyclin dependent kinase 1 (CDK1) that is a master kinase for mitotic progression, promoting proper kinetochore ...
Reito Watanabe, Masatoshi Hara, Mariko Ariyoshi, Tatsuo Fukagawa   +3 more
openaire   +3 more sources

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer [PDF]

Advanced science
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Alexandrou S, Fernandez K, Huang M, Millar E, Vennin C, Eshraghi L, Lam T, Lee V, Brooks N, Stoehr J, Mendez C, Strathdee D, Stevenson D, Herrmann D, O'Toole S, Timpson P, Nobis M, Caldon C.   +17 more
europepmc   +2 more sources

Inhibition of CDK1 activity by sumoylation [PDF]

Biochemical and Biophysical Research Communications, 2016
Sumoylation (a covalent modification by Small Ubiquitin-like Modifiers or SUMO proteins) has been implicated in the regulation of various cellular events including cell cycle progression. We have recently identified CDK1, a master regulator of mitosis and meiosis, as a SUMO target both in vivo and in vitro, supporting growing evidence concerning a ...
Yuxuan Xiao, Benjamin Lucas, Elana Molcho, Tania Schiff, Margarita Vigodner   +4 more
openaire   +2 more sources