Results 41 to 50 of about 74,242 (343)
CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity.
Biochemical and Biophysical Research Communications - BBRC, 2021 CDK1 plays key roles in cell cycle progression through the G2/M phase transition and activation of homologous recombination (HR) DNA repair pathway. Accordingly, various CDK1 inhibitors have been developed for cancer therapy that induce prolonged G2 ...
Shigeaki Sunada +4 more
semanticscholar +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation
Cell Reports, 2023 Summary: Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we show how CDK1 activity and non-
Aymen al-Rawi +4 more
doaj +1 more source
LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]
, 2015 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T +8 more
core +1 more source
Nuclear-cytoplasmic compartmentalization of cyclin B1-Cdk1 promotes robust timing of mitotic events.
Cell Reports, 2022 The cyclin-dependent kinase (Cdk1) oscillator is widely characterized in homogenized cytosolic extracts, leaving unclear the impact of nucleocytoplasmic compartmentalization.
Gembu Maryu, Qiong Yang
semanticscholar +1 more source
CDK1 is up-regulated by temozolomide in an NF-κB dependent manner in glioblastoma
Scientific Reports, 2021 The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 ...
David J. Voce +9 more
doaj +1 more source
, 2019 The corn smut fungus uses two different mechanisms to control its cell cycle when it is infecting ...
Bardetti +8 more
core +1 more source
Experimental and Molecular Medicine, 2022 Aberrant activation of embryogenesis-related molecular programs in urothelial bladder cancer (BC) is associated with stemness features related to oncogenic dedifferentiation and tumor metastasis. Recently, we reported that overexpression of transcription
Jinbeom Heo +15 more
semanticscholar +1 more source
CDK1 phosphorylates WRN at collapsed replication forks [PDF]
Nature Communications, 2016 Abstract Regulation of end-processing is critical for accurate repair and to switch between homologous recombination (HR) and non-homologous end joining (NHEJ). End resection is a two-stage process but very little is known about regulation of the long-range resection, especially in humans.
Valentina Palermo +8 more
openaire +3 more sources
Cells, 2023 The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj +1 more source