Results 41 to 50 of about 46,551 (257)

PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

Frontiers in Oncology, 2022
PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba, Shigeo Ohba, Yongjian Tang, Yongjian Tang, Tor-Christian Aase Johannessen, Tor-Christian Aase Johannessen, Joydeep Mukherjee   +6 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies

Nucleus, 2020
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj   +1 more source

Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance

FEBS Open Bio, 2021
Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC).
Han‐Jie Zhang, Gang Chen, Shang‐Wei Chen, Zong‐Wang Fu, Hua‐Fu Zhou, Zhen‐Bo Feng, Jun‐Xian Mo, Chang‐Bo Li, Jun Liu   +8 more
doaj   +1 more source

Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

, 2021
© 2020 Elsevier Inc. The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1.
Sicinski, Piotr, Young, Richard A, Kolodziejczyk, Aleksandra, Sweeney, Katharine E, Wernig, Marius, Geng, Yan, Chick, Joel M, Marro, Samuele, Otto, Tobias, Liu, Lijun, Zhang, Tian, Li Cheong Man, Mitchell, Moses, Alan, Fassl, Anne, Day, Daniel, Sharma, Samanta, Bacon, Nickolas A, Dunkl, Lukas M, Chu, Chen, Anders, Lars, Han, Richard, Laphanuwat, Phatthamon, Li, Cheng, Gygi, Steven P, Michowski, Wojciech, Abraham, Brian Joseph, Jecrois, Emanuelle, Wang, Yichen, Suski, Jan M   +28 more
core   +1 more source

Regulation of sororin by Cdk1-mediated phosphorylation [PDF]

Journal of Cell Science, 2011
Tumor cells are commonly aneuploid, a condition contributing to cancer progression and drug resistance. Understanding how chromatids are linked and separated at the appropriate time will help uncover the basis of aneuploidy and will shed light on the behavior of tumor cells.
Megan R, Dreier, Michael E, Bekier, William R, Taylor   +2 more
openaire   +2 more sources

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source

An overview of Cdk1-controlled targets and processes [PDF]

Cell Division, 2010
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle.
Enserink, Jorrit M, Kolodner, Richard D
openaire   +5 more sources

Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

Cell Reports, 2023
Summary: Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we show how CDK1 activity and non-
Aymen al-Rawi, Edward Kaye, Svitlana Korolchuk, Jane A. Endicott, Tony Ly   +4 more
doaj   +1 more source

CDK1 is up-regulated by temozolomide in an NF-κB dependent manner in glioblastoma

Scientific Reports, 2021
The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 ...
David J. Voce, Giovanna M. Bernal, Kirk E. Cahill, Longtao Wu, Nassir Mansour, Clayton D. Crawley, Paige-Ashley S. Campbell, Ainhoa Arina, Ralph R. Weichselbaum, Bakhtiar Yamini   +9 more
doaj   +1 more source