Results 61 to 70 of about 74,242 (343)

Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells.

Molecules and Cells, 2020
The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1.
W. Michowski, Joel M. Chick, C. Chu, Aleksandra A. Kolodziejczyk, Yichen Wang, Jan M. Suski, B. Abraham, L. Anders, Daniel S. Day, L. M. Dunkl, Mitchell Li Cheong Man, Tian Zhang, Phatthamon Laphanuwat, Nickolas A. Bacon, Lijun Liu, A. Fassl, Samanta Sharma, T. Otto, Emanuelle Jecrois, Richard C. Han, Katharine E Sweeney, Samuele G. Marro, Marius Wernig, Y. Geng, Alan M. Moses, Cheng Li, S. Gygi, R. Young, P. Sicinski   +28 more
semanticscholar   +1 more source

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Medical Science Monitor, 2020
Background Orderly G2/M transition in the cell cycle is controlled by the cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships
Yiping Zou, Shiye Ruan, Liang Jin, Zhihong Chen, Hongwei Han, Yuanpeng Zhang, Z. Jian, Ye Lin, N. Shi, Haosheng Jin   +9 more
semanticscholar   +1 more source

CDK1 couples proliferation with protein synthesis

Journal of Cell Biology, 2019
Cell proliferation exerts a high demand on protein synthesis, yet the mechanisms coupling the two processes are not fully understood. A kinase and phosphatase screen for activators of translation, based on the formation of stress granules in human cells, revealed cell cycle–associated kinases as major candidates.
Katharina Haneke, Johanna Schott, Doris Lindner, Anne Kruse Hollensen, Christian Kroun Damgaard, Cyril Mongis, Michael Knop, Wilhelm Palm, Alessia Ruggieri, Georg Stoecklin   +9 more
openaire   +3 more sources

Rescue of a Human Cell Line from Endogenous Cdk1 Depletion by Cdk1 Lacking Inhibitory Phosphorylation Sites [PDF]

Journal of Biological Chemistry, 2007
Cells that transiently overexpress cyclin-dependent kinase 1 lacking inhibitory phosphorylation sites (Cdk1-AF) undergo premature and catastrophic mitosis, reflecting the key role for Cdk1 in promoting a timely transit from G(2) into mitosis. Conversely, cells depleted of Cdk1 undergo repeated S phases without intervening mitoses (endoreduplication ...
Mita, Gupta, Deborah, Trott, Andrew C G, Porter   +2 more
openaire   +2 more sources

Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer

Drug Design, Development and Therapy, 2023
Mei Zhao,1,2 Lijuan Fu,1,2 Panling Xu,1,2 Ting Wang,1,2 Ping Li1,2 1Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Integrated Traditional ...
Zhao M, Fu L, Xu P, Wang T, Li P
doaj  

DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

Biomolecules, 2021
DNMT3A mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice.
Ying Yang, Yujun Dai, Xuejiao Yang, Songfang Wu, Yueying Wang   +4 more
doaj   +1 more source

Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. [PDF]

, 2020
Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit
Candas-Green, Demet, Chen, Hong-Wu, Fan, Ming, Hu, Yiyang, Jiang, Joy X, Li, Jian Jian, Liu, Lin, Wang, Yinsheng, Wei, Ryan, Xie, Bowen   +9 more
core  

lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis

Aging, 2021
Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play a critical role in CRC tumorigenesis.
Zhongyi Zhou, Fengbo Tan, Q. Pei, Chenglong Li, Yuanquan Zhou, Yuqiang Li, Haiping Pei   +6 more
semanticscholar   +1 more source

Regulation of sororin by Cdk1-mediated phosphorylation [PDF]

Journal of Cell Science, 2011
Tumor cells are commonly aneuploid, a condition contributing to cancer progression and drug resistance. Understanding how chromatids are linked and separated at the appropriate time will help uncover the basis of aneuploidy and will shed light on the behavior of tumor cells.
Megan R, Dreier, Michael E, Bekier, William R, Taylor   +2 more
openaire   +2 more sources