Results 61 to 70 of about 46,551 (257)
徐州医科大学学报Objective To investigate the role and mechanism of serine/arginine-rich splicing factor 1 (SRSF1) in promoting cardiomyocyte senescence during myocardial ischemia-reperfusion injury (MIRI).
LI Wenjing, DAI Rui
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Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
eLife, 2022 Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip +7 more
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MicroRNAs and target genes as regulators of colon cancer immune signaling
Медицинская иммунологияColorectal cancer (CRC) is among the most common oncological diseases in the world, associated with a high mortality rate. Recently, immunotherapeutic approaches to the treatment of CRC have been developed, which have enabled achievement of long-term and
O. I. Kit +5 more
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Protein expression of CDK1 and p-CDK1 in rat spleens.
, 2015 (A) Western blot determination of CDK1 and p-CDK1 protein expression in control and aniline-treated rats. (B) Densitometric analysis of protein expressions. Values are mean ± SD; *p < 0.05.
Gangduo Wang (572128) +2 more
core +1 more source
Mitotic spindle assembly relies on localized control of Cdk1 activity [PDF]
, 2021 During cell division, mitosis involves profound rearrangements of the cytoskeleton such that the interphase microtubular network is rapidly dismantled while highly dynamic microtubules (MTs) nucleated from centrosomes start a chromosome search and ...
Serpico, Angela Flavia
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer
Cancer Management and Research, 2020 Yiping Zhu,1 Kai Li,2 Jieling Zhang,2 Lu Wang,1 Lili Sheng,1 Liang Yan2 1Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2Provincial Key Laboratory of Biological Macro ...
Zhu Y +5 more
doaj
USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer
Acta Biochimica et Biophysica Sinica, 2022 Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan +6 more
doaj +1 more source
BDNF induces Tyr15 phosphorylation in cdk1.
, 2013 (A) Validation of the cdk1 sandwich ELISA assay performed with 10 fg of either GST (GST) or a chimeric protein containing the sequence of human cdk1 bound to GST (Cdk1-GST), and revealed with the anti-cdk1 PSTAIRE antibody.
María C. Ovejero-Benito (417355) +1 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source