Results 71 to 80 of about 74,242 (343)
Cancer Management and Research, 2021 Deng YR, Chen XJ, Chen W, et al. Cancer Manag Res. 2019;11:5835–5844. The authors have advised due to an error at the time of figure assembly, Figure 3A on page 5840 is incorrect. The correct Figure 3 is shown in Download Article.
Deng YR +8 more
doaj
Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. [PDF]
, 2015 Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene overexpression that rarely matches ...
Dowdy, Steven F +5 more
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Polarized Cell Growth: Double Grip by CDK1 [PDF]
Current Biology, 2007 Precise coupling of cell growth and cell-cycle progression is crucial for achieving cell homeostasis. A recent study sheds light on two distinct roles of cyclin-dependent kinase 1 (CDK1) in promoting polarized cell growth in budding yeast.
Rancati, Giulia, Li, Rong
openaire +2 more sources
Cancer Management and Research, 2020 Shufen Zhao,1 Baiyao Wang,2 Yanning Ma,3 Junjie Kuang,1 Jiyun Liang,3 Yawei Yuan1,2 1Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People’s Republic of China; 2Department
Zhao S +5 more
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Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. [PDF]
, 2010 The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle.
Afshan McCarthy +9 more
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徐州医科大学学报Objective To investigate the role and mechanism of serine/arginine-rich splicing factor 1 (SRSF1) in promoting cardiomyocyte senescence during myocardial ischemia-reperfusion injury (MIRI).
LI Wenjing, DAI Rui
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Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
eLife, 2022 Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip +7 more
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DNA damage stress: Cui prodest? [PDF]
, 2019 DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha +5 more
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Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]
, 2016 BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N. +6 more
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Cell Death and DiseaseGlioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, high mortality, and poor patient prognosis.
Mingxin Ci +11 more
semanticscholar +1 more source