Results 81 to 90 of about 46,551 (257)
Advanced Science, EarlyView.Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang +18 more
wiley +1 more source
CDK1 phosphorylates WRN at collapsed replication forks [PDF]
Nature Communications, 2016 Abstract Regulation of end-processing is critical for accurate repair and to switch between homologous recombination (HR) and non-homologous end joining (NHEJ). End resection is a two-stage process but very little is known about regulation of the long-range resection, especially in humans.
Palermo, V. +9 more
openaire +4 more sources
COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells
Stem Cell Reports, 2018 Summary: Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate.
Peng Li +3 more
doaj +1 more source
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
PLoS ONE, 2016 The p17 protein of avian reovirus (ARV) causes cell cycle retardation in a variety of cell lines; however, the underlying mechanism(s) by which p17 regulates the cell cycle remains largely unknown.
Hung-Chuan Chiu +7 more
doaj +1 more source
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1 [PDF]
Cell, 2005 The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis.
Harvey, Stacy L. +4 more
openaire +2 more sources
Novel Modes of Regulation of Cyclin Dependent Kinase Cdk1 [PDF]
, 2014 Les quinases dependents de ciclina (CDKs) dirigeixen la progressió del cicle cel·lular a les cèl·lules eucariotes. A l'organisme eucariota model Saccharomyces cerevisiae (llevat de gemmació) una sola quinasa dependent de ciclina, Cdk1, és essencial i ...
Zeng, Fanli +1 more
core +3 more sources
This study aimed to analyze multiomics data and construct a regulatory network involving kinases, transcription factors, and immune genes in hepatocellular carcinoma (HCC) prognosis.
De-Hui Yi (17374841) +1 more
core +1 more source
Analysis of Developmental Relevance of Cdk1 Inhibitory Phosphorylation in Drosophila
, 2014 Cyclin dependent kinase 1, Cdk1, inhibitory phosphorylation is at the core of conserved checkpoint mechanisms that prevent mitosis from interfering with DNA replication or repair.
Ayeni, Joseph O
core +1 more source